Anti-CASP8 TCR Products - Creative Biolabs

CASP8

This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This protein is involved in the programmed cell death induced by Fas and various apoptotic stimuli. The N-terminal FADD-like death effector domain of this protein suggests that it may interact with Fas-interacting protein FADD. This protein was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls, which implicated the role in neurodegenerative diseases. Many alternatively spliced transcript variants encoding different isoforms have been described, although not all variants have had their full-length sequences determined.

Associated Disease

Head-and-neck cancer

Vector Products
Viral Particles

TCR Vector Products Product list:

Catalog	Target	Target Species	Antibody Clone	scFv-Host Animal	Vector length	Vector Type	Epitope	Format	HLA	Data sheet	Price
TCR-C025Z	CASP8	Human	121	Human	~8kb	Lentiviral	FPSDSWCYF	Non-modified	HLA-B*3503		Inquiry

TCR Viral Particles Product list:

Catalog	Target Species	Antibody Clone	scFv-Host Animal	Packaging System	Epitope	Format	Titer	Data sheet	Price
VP-TCR-C025	Human	121	Human	Lentivirus	FPSDSWCYF	Non-modified TCR	> 10⁷ IFU/ml		Inquiry

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