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CASP8

This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This protein is involved in the programmed cell death induced by Fas and various apoptotic stimuli. The N-terminal FADD-like death effector domain of this protein suggests that it may interact with Fas-interacting protein FADD. This protein was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls, which implicated the role in neurodegenerative diseases. Many alternatively spliced transcript variants encoding different isoforms have been described, although not all variants have had their full-length sequences determined.

Associated Disease
  • Head-and-neck cancer
  • CAR Vector Products
  • TCR Vector Products
  • TCR Viral Particles
  • DMAb
CAT Product Name Target Species Antibody Clone Antibody Host Receptor Construction Vector Type Targeting Cell Type  
CAR-WJ0104 Anti-CASP8 (CBWJC-0750) h(41BB-CD3ζ) CAR, pCDCAR1 Human CBWJC-0750 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Inquiry
  Datasheet
CAR-WJ2390 Anti-CASP8 (FLICE 1 1-37) h(CD28-CD3ζ) CAR, pCDCAR1 Human FLICE 1 1-37 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Inquiry
  Datasheet
CAR-WJ2391 Anti-CASP8 (CBWJC-0746) h(CD28-CD3ζ) CAR, pCDCAR1 Human CBWJC-0746 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Inquiry
  Datasheet
CAR-WJ2392 Anti-CASP8 (FLICE 4-1-20) h(CD28-CD3ζ) CAR, pCDCAR1 Human FLICE 4-1-20 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Inquiry
  Datasheet
CAR-WJ2393 Anti-CASP8 (CBWJC-0747) h(CD28-CD3ζ) CAR, pCDCAR1 Human CBWJC-0747 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Inquiry
  Datasheet
CAR-WJ2394 Anti-CASP8 (CBWJC-0748) h(CD28-CD3ζ) CAR, pCDCAR1 Human CBWJC-0748 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Inquiry
  Datasheet
CAR-WJ2395 Anti-CASP8 (CBWJC-0749) h(CD28-CD3ζ) CAR, pCDCAR1 Human CBWJC-0749 Rat scFv-CD28-CD3ζ Lentiviral vector T cell   Inquiry
  Datasheet
CAR-WJ2396 Anti-CASP8 (CBWJC-0750) h(CD28-CD3ζ) CAR, pCDCAR1 Human CBWJC-0750 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Inquiry
  Datasheet
CAR-WFY2661 Anti-CASP8 (CBFYC-0853) h(41BB-CD3ζ) CAR, pCDCAR1 Human CBFYC-0853 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Inquiry
  Datasheet
CAR-WFY2662 Anti-CASP8 (CBFYC-0854) h(41BB-CD3ζ) CAR, pCDCAR1 Mouse CBFYC-0854 Rat scFv-41BB-CD3ζ Lentiviral vector T cell   Inquiry
  Datasheet
CAR-WFY2663 Anti-CASP8 (CBFYC-0855) h(41BB-CD3ζ) CAR, pCDCAR1 Human CBFYC-0855 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Inquiry
  Datasheet
CAR-WFY2664 Anti-CASP8 (CBFYC-0856) h(41BB-CD3ζ) CAR, pCDCAR1 Human, Mouse, Rat CBFYC-0856 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Inquiry
  Datasheet
CAR-WFY2665 Anti-CASP8 (CBFYC-0857) h(41BB-CD3ζ) CAR, pCDCAR1 Mouse CBFYC-0857 Rat scFv-41BB-CD3ζ Lentiviral vector T cell   Inquiry
  Datasheet
CAR-WFY2666 Anti-CASP8 (CBFYC-0858) h(41BB-CD3ζ) CAR, pCDCAR1 Human CBFYC-0858 Rabbit scFv-41BB-CD3ζ Lentiviral vector T cell   Inquiry
  Datasheet
CAR-WFY2667 Anti-CASP8 (CBFYC-0859) h(41BB-CD3ζ) CAR, pCDCAR1 Human CBFYC-0859 Rat scFv-41BB-CD3ζ Lentiviral vector T cell   Inquiry
  Datasheet
CAR-WFY5914 Anti-CASP8 (CBFYC-0853) h(CD28-CD3ζ) CAR, pCDCAR1 Human CBFYC-0853 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Inquiry
  Datasheet
CAR-WFY5915 Anti-CASP8 (CBFYC-0854) h(CD28-CD3ζ) CAR, pCDCAR1 Mouse CBFYC-0854 Rat scFv-CD28-CD3ζ Lentiviral vector T cell   Inquiry
  Datasheet
CAR-WFY5916 Anti-CASP8 (CBFYC-0855) h(CD28-CD3ζ) CAR, pCDCAR1 Human CBFYC-0855 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Inquiry
  Datasheet
CAR-WFY5917 Anti-CASP8 (CBFYC-0856) h(CD28-CD3ζ) CAR, pCDCAR1 Human, Mouse, Rat CBFYC-0856 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Inquiry
  Datasheet
CAR-WFY5918 Anti-CASP8 (CBFYC-0857) h(CD28-CD3ζ) CAR, pCDCAR1 Mouse CBFYC-0857 Rat scFv-CD28-CD3ζ Lentiviral vector T cell   Inquiry
  Datasheet
CAR-WFY5919 Anti-CASP8 (CBFYC-0858) h(CD28-CD3ζ) CAR, pCDCAR1 Human CBFYC-0858 Rabbit scFv-CD28-CD3ζ Lentiviral vector T cell   Inquiry
  Datasheet
CAR-WFY5920 Anti-CASP8 (CBFYC-0859) h(CD28-CD3ζ) CAR, pCDCAR1 Human CBFYC-0859 Rat scFv-CD28-CD3ζ Lentiviral vector T cell   Inquiry
  Datasheet
CAR-WJ0084 Anti-CASP8 (CARL-1) h(41BB-CD3ζ) CAR, pCDCAR1 Human CARL-1 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Inquiry
  Datasheet
CAR-WJ0085 Anti-CASP8 (CBWJC-0060) h(41BB-CD3ζ) CAR, pCDCAR1 Human CBWJC-0060 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Inquiry
  Datasheet
CAR-WJ0086 Anti-CASP8 (CBWJC-0061) h(41BB-CD3ζ) CAR, pCDCAR1 Mouse CBWJC-0061 Rabbit scFv-41BB-CD3ζ Lentiviral vector T cell   Inquiry
  Datasheet
CAR-WJ0087 Anti-CASP8 (CBWJC-0062) h(41BB-CD3ζ) CAR, pCDCAR1 Human CBWJC-0062 Rabbit scFv-41BB-CD3ζ Lentiviral vector T cell   Inquiry
  Datasheet
CAR-WJ0088 Anti-CASP8 (CBWJC-0063) h(41BB-CD3ζ) CAR, pCDCAR1 Human CBWJC-0063 Rabbit scFv-41BB-CD3ζ Lentiviral vector T cell   Inquiry
  Datasheet
CAR-WJ0089 Anti-CASP8 (CBWJC-0738) h(41BB-CD3ζ) CAR, pCDCAR1 Human CBWJC-0738 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Inquiry
  Datasheet
CAR-WJ0090 Anti-CASP8 (CBWJC-0739) h(41BB-CD3ζ) CAR, pCDCAR1 Human CBWJC-0739 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Inquiry
  Datasheet
CAR-WJ0091 Anti-CASP8 (CBWJC-0740) h(41BB-CD3ζ) CAR, pCDCAR1 Human CBWJC-0740 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Inquiry
  Datasheet
CAR-WJ0092 Anti-CASP8 (C502S) h(41BB-CD3ζ) CAR, pCDCAR1 Human C502S Rabbit scFv-41BB-CD3ζ Lentiviral vector T cell   Inquiry
  Datasheet
CAR-WJ0093 Anti-CASP8 (CBWJC-0741) h(41BB-CD3ζ) CAR, pCDCAR1 Human CBWJC-0741 scFv-41BB-CD3ζ Lentiviral vector T cell   Inquiry
  Datasheet
CAR-WJ0094 Anti-CASP8 (CBWJC-0742) h(41BB-CD3ζ) CAR, pCDCAR1 CBWJC-0742 Rabbit scFv-41BB-CD3ζ Lentiviral vector T cell   Inquiry
  Datasheet
CAR-WJ0095 Anti-CASP8 (CBWJC-0743) h(41BB-CD3ζ) CAR, pCDCAR1 Human CBWJC-0743 Rabbit scFv-41BB-CD3ζ Lentiviral vector T cell   Inquiry
  Datasheet
CAR-WJ0096 Anti-CASP8 (CBWJC-0744) h(41BB-CD3ζ) CAR, pCDCAR1 CBWJC-0744 Rabbit scFv-41BB-CD3ζ Lentiviral vector T cell   Inquiry
  Datasheet
CAR-WJ0097 Anti-CASP8 (CBWJC-0745) h(41BB-CD3ζ) CAR, pCDCAR1 CBWJC-0745 Rabbit scFv-41BB-CD3ζ Lentiviral vector T cell   Inquiry
  Datasheet
CAR-WJ0098 Anti-CASP8 (FLICE 1 1-37) h(41BB-CD3ζ) CAR, pCDCAR1 Human FLICE 1 1-37 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Inquiry
  Datasheet
CAR-WJ0099 Anti-CASP8 (CBWJC-0746) h(41BB-CD3ζ) CAR, pCDCAR1 Human CBWJC-0746 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Inquiry
  Datasheet
CAR-WJ0100 Anti-CASP8 (FLICE 4-1-20) h(41BB-CD3ζ) CAR, pCDCAR1 Human FLICE 4-1-20 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Inquiry
  Datasheet
CAR-WJ0101 Anti-CASP8 (CBWJC-0747) h(41BB-CD3ζ) CAR, pCDCAR1 Human CBWJC-0747 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Inquiry
  Datasheet

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