CASP8

This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This protein is involved in the programmed cell death induced by Fas and various apoptotic stimuli. The N-terminal FADD-like death effector domain of this protein suggests that it may interact with Fas-interacting protein FADD. This protein was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls, which implicated the role in neurodegenerative diseases. Many alternatively spliced transcript variants encoding different isoforms have been described, although not all variants have had their full-length sequences determined.

Associated Disease
  • Head-and-neck cancer

CAR Vector Products Product list:

Catalog Targeting
Cell Type
Generation Antibody
Clone
Vector
Length
Vector
Type
Vector Design Antibody
Host
Data
sheet
Price
CAR-CQ0109 T cell Second CBXC-3111 ~8kb Lentiviral vector scFv-41BB-CD3ζ Mouse Inquiry
CAR-CQ0110 T cell Second CBXC-0083 ~8kb Lentiviral vector scFv-41BB-CD3ζ Mouse Inquiry
CAR-CQ0111 T cell Second C15 ~8kb Lentiviral vector scFv-41BB-CD3ζ Mouse Inquiry
CAR-CQ0112 T cell Second CBXC-0084 ~8kb Lentiviral vector scFv-41BB-CD3ζ Mouse Inquiry
CAR-CQ0113 T cell Second CBXC-2270 ~8kb Lentiviral vector scFv-41BB-CD3ζ Mouse Inquiry
CAR-CQ0114 T cell Second CBXC-0082 ~8kb Lentiviral vector scFv-41BB-CD3ζ Mouse Inquiry
CAR-CQ0115 T cell Second CBXC-1334 ~8kb Lentiviral vector scFv-41BB-CD3ζ Mouse Inquiry
CAR-CQ0116 T cell Second FLICE 4-1-20 ~8kb Lentiviral vector scFv-41BB-CD3ζ Mouse Inquiry
CAR-CQ3533 T cell Second CBXC-3111 ~8kb Lentiviral vector scFv-CD28-CD3ζ Mouse Inquiry
CAR-CQ3534 T cell Second CBXC-0083 ~8kb Lentiviral vector scFv-CD28-CD3ζ Mouse Inquiry
CAR-CQ3535 T cell Second C15 ~8kb Lentiviral vector scFv-CD28-CD3ζ Mouse Inquiry
CAR-CQ3536 T cell Second CBXC-0084 ~8kb Lentiviral vector scFv-CD28-CD3ζ Mouse Inquiry
CAR-CQ3537 T cell Second CBXC-2270 ~8kb Lentiviral vector scFv-CD28-CD3ζ Mouse Inquiry
CAR-CQ3538 T cell Second CBXC-0082 ~8kb Lentiviral vector scFv-CD28-CD3ζ Mouse Inquiry
CAR-CQ3539 T cell Second CBXC-1334 ~8kb Lentiviral vector scFv-CD28-CD3ζ Mouse Inquiry
CAR-CQ3540 T cell Second FLICE 4-1-20 ~8kb Lentiviral vector scFv-CD28-CD3ζ Mouse Inquiry
CAR-WFY2661 T cell Second CBFYC-0853 ~8kb Lentiviral vector scFv-41BB-CD3ζ Mouse Inquiry
CAR-WFY2662 T cell Second CBFYC-0854 ~8kb Lentiviral vector scFv-41BB-CD3ζ Rat Inquiry
CAR-WFY2663 T cell Second CBFYC-0855 ~8kb Lentiviral vector scFv-41BB-CD3ζ Mouse Inquiry
CAR-WFY2664 T cell Second CBFYC-0856 ~8kb Lentiviral vector scFv-41BB-CD3ζ Mouse Inquiry
CAR-WFY2665 T cell Second CBFYC-0857 ~8kb Lentiviral vector scFv-41BB-CD3ζ Rat Inquiry
CAR-WFY2666 T cell Second CBFYC-0858 ~8kb Lentiviral vector scFv-41BB-CD3ζ Rabbit Inquiry
CAR-WFY2667 T cell Second CBFYC-0859 ~8kb Lentiviral vector scFv-41BB-CD3ζ Rat Inquiry
CAR-WFY5914 T cell Second CBFYC-0853 ~8kb Lentiviral vector scFv-CD28-CD3ζ Mouse Inquiry
CAR-WFY5915 T cell Second CBFYC-0854 ~8kb Lentiviral vector scFv-CD28-CD3ζ Rat Inquiry
CAR-WFY5916 T cell Second CBFYC-0855 ~8kb Lentiviral vector scFv-CD28-CD3ζ Mouse Inquiry
CAR-WFY5917 T cell Second CBFYC-0856 ~8kb Lentiviral vector scFv-CD28-CD3ζ Mouse Inquiry
CAR-WFY5918 T cell Second CBFYC-0857 ~8kb Lentiviral vector scFv-CD28-CD3ζ Rat Inquiry
CAR-WFY5919 T cell Second CBFYC-0858 ~8kb Lentiviral vector scFv-CD28-CD3ζ Rabbit Inquiry
CAR-WFY5920 T cell Second CBFYC-0859 ~8kb Lentiviral vector scFv-CD28-CD3ζ Rat Inquiry
CAR-WJ0084 T cell Second CARL-1 ~8kb Lentiviral vector scFv-41BB-CD3ζ Mouse Inquiry
CAR-WJ0085 T cell Second CBWJC-0060 ~8kb Lentiviral vector scFv-41BB-CD3ζ Mouse Inquiry
CAR-WJ0086 T cell Second CBWJC-0061 ~8kb Lentiviral vector scFv-41BB-CD3ζ Rabbit Inquiry
CAR-WJ0087 T cell Second CBWJC-0062 ~8kb Lentiviral vector scFv-41BB-CD3ζ Rabbit Inquiry
CAR-WJ0088 T cell Second CBWJC-0063 ~8kb Lentiviral vector scFv-41BB-CD3ζ Rabbit Inquiry
CAR-WJ0089 T cell Second CBWJC-0738 ~8kb Lentiviral vector scFv-41BB-CD3ζ Mouse Inquiry
CAR-WJ0090 T cell Second CBWJC-0739 ~8kb Lentiviral vector scFv-41BB-CD3ζ Mouse Inquiry
CAR-WJ0091 T cell Second CBWJC-0740 ~8kb Lentiviral vector scFv-41BB-CD3ζ Mouse Inquiry
CAR-WJ0092 T cell Second C502S ~8kb Lentiviral vector scFv-41BB-CD3ζ Rabbit Inquiry
CAR-WJ0093 T cell Second CBWJC-0741 ~8kb Lentiviral vector scFv-41BB-CD3ζ Inquiry
CAR-WJ0094 T cell Second CBWJC-0742 ~8kb Lentiviral vector scFv-41BB-CD3ζ Rabbit Inquiry
CAR-WJ0095 T cell Second CBWJC-0743 ~8kb Lentiviral vector scFv-41BB-CD3ζ Rabbit Inquiry
CAR-WJ0096 T cell Second CBWJC-0744 ~8kb Lentiviral vector scFv-41BB-CD3ζ Rabbit Inquiry
CAR-WJ0097 T cell Second CBWJC-0745 ~8kb Lentiviral vector scFv-41BB-CD3ζ Rabbit Inquiry
CAR-WJ0098 T cell Second FLICE 1 1-37 ~8kb Lentiviral vector scFv-41BB-CD3ζ Mouse Inquiry
CAR-WJ0099 T cell Second CBWJC-0746 ~8kb Lentiviral vector scFv-41BB-CD3ζ Mouse Inquiry
CAR-WJ0100 T cell Second FLICE 4-1-20 ~8kb Lentiviral vector scFv-41BB-CD3ζ Mouse Inquiry
CAR-WJ0101 T cell Second CBWJC-0747 ~8kb Lentiviral vector scFv-41BB-CD3ζ Mouse Inquiry
CAR-WJ0102 T cell Second CBWJC-0748 ~8kb Lentiviral vector scFv-41BB-CD3ζ Mouse Inquiry
CAR-WJ0103 T cell Second CBWJC-0749 ~8kb Lentiviral vector scFv-41BB-CD3ζ Rat Inquiry
CAR-WJ0104 T cell Second CBWJC-0750 ~8kb Lentiviral vector scFv-41BB-CD3ζ Mouse Inquiry
CAR-WJ2376 T cell Second CARL-1 ~8kb Lentiviral vector scFv-CD28-CD3ζ Mouse Inquiry
CAR-WJ2377 T cell Second CBWJC-0060 ~8kb Lentiviral vector scFv-CD28-CD3ζ Mouse Inquiry
CAR-WJ2378 T cell Second CBWJC-0061 ~8kb Lentiviral vector scFv-CD28-CD3ζ Rabbit Inquiry
CAR-WJ2379 T cell Second CBWJC-0062 ~8kb Lentiviral vector scFv-CD28-CD3ζ Rabbit Inquiry
CAR-WJ2380 T cell Second CBWJC-0063 ~8kb Lentiviral vector scFv-CD28-CD3ζ Rabbit Inquiry
CAR-WJ2381 T cell Second CBWJC-0738 ~8kb Lentiviral vector scFv-CD28-CD3ζ Mouse Inquiry
CAR-WJ2382 T cell Second CBWJC-0739 ~8kb Lentiviral vector scFv-CD28-CD3ζ Mouse Inquiry
CAR-WJ2383 T cell Second CBWJC-0740 ~8kb Lentiviral vector scFv-CD28-CD3ζ Mouse Inquiry
CAR-WJ2384 T cell Second C502S ~8kb Lentiviral vector scFv-CD28-CD3ζ Rabbit Inquiry
CAR-WJ2385 T cell Second CBWJC-0741 ~8kb Lentiviral vector scFv-CD28-CD3ζ Inquiry
CAR-WJ2386 T cell Second CBWJC-0742 ~8kb Lentiviral vector scFv-CD28-CD3ζ Rabbit Inquiry
CAR-WJ2387 T cell Second CBWJC-0743 ~8kb Lentiviral vector scFv-CD28-CD3ζ Rabbit Inquiry
CAR-WJ2388 T cell Second CBWJC-0744 ~8kb Lentiviral vector scFv-CD28-CD3ζ Rabbit Inquiry
CAR-WJ2389 T cell Second CBWJC-0745 ~8kb Lentiviral vector scFv-CD28-CD3ζ Rabbit Inquiry
CAR-WJ2390 T cell Second FLICE 1 1-37 ~8kb Lentiviral vector scFv-CD28-CD3ζ Mouse Inquiry
CAR-WJ2391 T cell Second CBWJC-0746 ~8kb Lentiviral vector scFv-CD28-CD3ζ Mouse Inquiry
CAR-WJ2392 T cell Second FLICE 4-1-20 ~8kb Lentiviral vector scFv-CD28-CD3ζ Mouse Inquiry
CAR-WJ2393 T cell Second CBWJC-0747 ~8kb Lentiviral vector scFv-CD28-CD3ζ Mouse Inquiry
CAR-WJ2394 T cell Second CBWJC-0748 ~8kb Lentiviral vector scFv-CD28-CD3ζ Mouse Inquiry
CAR-WJ2395 T cell Second CBWJC-0749 ~8kb Lentiviral vector scFv-CD28-CD3ζ Rat Inquiry
CAR-WJ2396 T cell Second CBWJC-0750 ~8kb Lentiviral vector scFv-CD28-CD3ζ Mouse Inquiry

TCR Vector Products Product list:

Catalog Target Target
Species
Antibody
Clone
scFv-Host
Animal
Vector
length
Vector
Type
Epitope Format HLA Data
sheet
Price
TCR-C025Z CASP8 Human 121 Human ~8kb Lentiviral FPSDSWCYF Non-modified HLA-B*3503 Inquiry

TCR Viral Particles Product list:

Catalog Target
Species
Antibody
Clone
scFv-Host
Animal
Packaging
System
Epitope Format Titer Data
sheet
Price
VP-TCR-C025 Human 121 Human Lentivirus FPSDSWCYF Non-modified TCR > 10⁷ IFU/ml Inquiry

DMAb Product list:

Catalog Target Target Species DMAb Host DMAb Cross Reactivity DMAb Clone Vector Name Data
sheet
Price
DMAb-2661-FY CASP8 Human Mouse Human CBFYC-0853 pVAX1 Inquiry
DMAb-2662-FY CASP8 Mouse Rat Mouse CBFYC-0854 pVAX1 Inquiry
DMAb-2663-FY CASP8 Human Mouse Human CBFYC-0855 pVAX1 Inquiry
DMAb-2664-FY CASP8 Human Mouse Human, Mouse, Rat CBFYC-0856 pVAX1 Inquiry
DMAb-2665-FY CASP8 Mouse Rat Mouse CBFYC-0857 pVAX1 Inquiry
DMAb-2666-FY CASP8 Human Rabbit Human CBFYC-0858 pVAX1 Inquiry
DMAb-2667-FY CASP8 Human Rat Human CBFYC-0859 pVAX1 Inquiry
DMAb-0109-CQ CASP8 Mouse Human, Primate CBXC-3111 pVAX1 Inquiry
DMAb-0110-CQ CASP8 Mouse Human CBXC-0083 pVAX1 Inquiry
DMAb-0111-CQ CASP8 Mouse Human C15 pVAX1 Inquiry
DMAb-0112-CQ CASP8 Mouse Human CBXC-0084 pVAX1 Inquiry
DMAb-0113-CQ CASP8 Mouse Human CBXC-2270 pVAX1 Inquiry
DMAb-0114-CQ CASP8 Mouse Human CBXC-0082 pVAX1 Inquiry
DMAb-0115-CQ CASP8 Mouse Human CBXC-1334 pVAX1 Inquiry
DMAb-0116-CQ CASP8 Mouse Human FLICE 4-1-20 pVAX1 Inquiry
DMAb-0084-WJ CASP8 Human Mouse Human CARL-1 pVAX1 Inquiry
DMAb-0085-WJ CASP8 Human Mouse Human CBWJC-0060 pVAX1 Inquiry
DMAb-0086-WJ CASP8 Mouse Rabbit Mouse CBWJC-0061 pVAX1 Inquiry
DMAb-0087-WJ CASP8 Human Rabbit Human CBWJC-0062 pVAX1 Inquiry
DMAb-0088-WJ CASP8 Human Rabbit Human CBWJC-0063 pVAX1 Inquiry
DMAb-0089-WJ CASP8 Human Mouse Human CBWJC-0738 pVAX1 Inquiry
DMAb-0090-WJ CASP8 Human Mouse Human CBWJC-0739 pVAX1 Inquiry
DMAb-0091-WJ CASP8 Human Mouse Human CBWJC-0740 pVAX1 Inquiry
DMAb-0092-WJ CASP8 Human Rabbit Human C502S pVAX1 Inquiry
DMAb-0093-WJ CASP8 Human Human CBWJC-0741 pVAX1 Inquiry
DMAb-0094-WJ CASP8 Rabbit Human, Mouse, Rat, Porcine CBWJC-0742 pVAX1 Inquiry
DMAb-0095-WJ CASP8 Human Rabbit Human CBWJC-0743 pVAX1 Inquiry
DMAb-0096-WJ CASP8 Rabbit Mouse, Rat, Human CBWJC-0744 pVAX1 Inquiry
DMAb-0097-WJ CASP8 Rabbit Mouse, Rat, Human CBWJC-0745 pVAX1 Inquiry
DMAb-0098-WJ CASP8 Human Mouse Human FLICE 1 1-37 pVAX1 Inquiry
DMAb-0099-WJ CASP8 Human Mouse Human CBWJC-0746 pVAX1 Inquiry
DMAb-0100-WJ CASP8 Human Mouse Human FLICE 4-1-20 pVAX1 Inquiry
DMAb-0101-WJ CASP8 Human Mouse Human CBWJC-0747 pVAX1 Inquiry
DMAb-0102-WJ CASP8 Human Mouse Human CBWJC-0748 pVAX1 Inquiry
DMAb-0103-WJ CASP8 Human Rat Human CBWJC-0749 pVAX1 Inquiry
DMAb-0104-WJ CASP8 Human Mouse Human CBWJC-0750 pVAX1 Inquiry
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