Anti-CASP8 T cell receptor (121), pCDTCR1(TCR-C025Z)
The vector of anti-CASP8 T cell receptor (TCR) is constructed for the engineering of T cell to target Human CASP8. The T cells are genetically modified through transduction with a lentiviral vector expressing CASP8-specific T cell receptor. And the vector product was designed for the treatment of Head-and-neck cancer.
CASP8; CAP4; MACH; MCH5; FLICE; ALPS2B; Casp-8; caspase 8
This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This protein is involved in the programmed cell death induced by Fas and various apoptotic stimuli. The N-terminal FADD-like death effector domain of this protein suggests that it may interact with Fas-interacting protein FADD. This protein was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls, which implicated the role in neurodegenerative diseases. Many alternatively spliced transcript variants encoding different isoforms have been described, although not all variants have had their full-length sequences determined.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.