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CD56

Neural cell adhesion molecule (NCAM), also called CD56, is a homophilic binding glycoprotein expressed on the surface of neurons, glia, skeletal muscle and natural killer cells. NCAM has been implicated as having a role in cell–cell adhesion, neurite outgrowth, synaptic plasticity, and learning and memory. NCAM is thought to signal to induce neurite outgrowth via the fibroblast growth factor receptor (FGFR) and act upon the p59Fyn signaling pathway. Tumors that are CD56-positive are myeloma, myeloid leukemia, neuroendocrine tumors, Wilms' tumor, neuroblastoma, NK/T cell lymphomas, pancreatic acinar cell carcinoma, pheochromocytoma, paraganglioma, small cell lung carcinoma, and the Ewing's sarcoma family of tumors. NCAM has been used as a target molecule for experimental antibody-based immunotherapy. Successful radioimmunolocalisation of metastases was demonstrated after giving injections of NCAM-binding 123J-UJ13a or 131J-UJ13a radioimmunoconjugates to children with neuroblastoma. Patients with small cell lung cancer were treated with the anti-NCAM immunotoxine huN901-DM1 in two different clinical studies, revealing acceptable toxicity and signs of clinical response.

Associated Disease
  • Relapsed refractory myeloma
  • Melanoma
  • CAR Vector Products
  • CAR Viral Particles
  • CAR Cell Products
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CAT Product Name Target Species Antibody Clone Antibody Host Receptor Construction Vector Type Targeting Cell Type Inquiry & Datasheet
CAR-ZP124 Anti-CD56 (N901) h(CD28-CD3ζ) CAR, pCDCAR1 Human N901 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP125 Anti-CD56 (N901) h(41BB-CD3ζ) CAR, pCDCAR1 Human N901 Mouse scFv-4-1BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP314 Anti-CD56 (S) h(CD28-CD3ζ) CAR, pCDCAR1 Human S Humanized scFv-CD28-CD3ζ Lentiviral vector NK cell   Add to Cart   Datasheet
CAR-ZP315 Anti-CD56 (S) h(41BB-CD3ζ) CAR, pCDCAR1 Human S Humanized scFv-4-1BB-CD3ζ Lentiviral vector NK cell   Add to Cart   Datasheet
CAR-ZP5773 Anti-CD56 (124D4) h(CD28-CD3ζ) CAR, pCDCAR1 Human 124D4 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP5774 Anti-CD56 (124D4) h(41BB-CD3ζ) CAR, pCDCAR1 Human 124D4 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP5775 Anti-CD56 (5A2) h(CD28-CD3ζ) CAR, pCDCAR1 Human 5A2 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP5776 Anti-CD56 (5A2) h(41BB-CD3ζ) CAR, pCDCAR1 Human 5A2 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP5777 Anti-CD56 (HCD56) h(CD28-CD3ζ) CAR, pCDCAR1 Human HCD56 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP5778 Anti-CD56 (HCD56) h(41BB-CD3ζ) CAR, pCDCAR1 Human HCD56 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP5779 Anti-CD56 (NCAM1/784) h(CD28-CD3ζ) CAR, pCDCAR1 Human NCAM1/784 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP5780 Anti-CD56 (NCAM1/784) h(41BB-CD3ζ) CAR, pCDCAR1 Human NCAM1/784 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP5781 Anti-CD56 (T199) h(CD28-CD3ζ) CAR, pCDCAR1 Human T199 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP5782 Anti-CD56 (T199) h(41BB-CD3ζ) CAR, pCDCAR1 Human T199 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP5783 Anti-CD56 (NCAM1/795) h(CD28-CD3ζ) CAR, pCDCAR1 Human NCAM1/795 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP5784 Anti-CD56 (NCAM1/795) h(41BB-CD3ζ) CAR, pCDCAR1 Human NCAM1/795 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP5785 Anti-CD56 (SPM489) h(CD28-CD3ζ) CAR, pCDCAR1 Human SPM489 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP5786 Anti-CD56 (SPM489) h(41BB-CD3ζ) CAR, pCDCAR1 Human SPM489 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP5787 Anti-CD56 (SPM128) h(CD28-CD3ζ) CAR, pCDCAR1 Human SPM128 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP5788 Anti-CD56 (SPM128) h(41BB-CD3ζ) CAR, pCDCAR1 Human SPM128 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP5789 Anti-CD56 (RNL-1) h(CD28-CD3ζ) CAR, pCDCAR1 Human RNL-1 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP5803 Anti-CD56 (1.BB.490) h(CD28-CD3ζ) CAR, pCDCAR1 Human 1.BB.490 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP5804 Anti-CD56 (1.BB.490) h(41BB-CD3ζ) CAR, pCDCAR1 Human 1.BB.490 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP5805 Anti-CD56 (5K269) h(CD28-CD3ζ) CAR, pCDCAR1 Human 5K269 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP5806 Anti-CD56 (5K269) h(41BB-CD3ζ) CAR, pCDCAR1 Human 5K269 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP5807 Anti-CD56 (IML-43) h(CD28-CD3ζ) CAR, pCDCAR1 Human IML-43 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP5808 Anti-CD56 (IML-43) h(41BB-CD3ζ) CAR, pCDCAR1 Human IML-43 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP5809 Anti-CD56 (NCAM1/1496) h(CD28-CD3ζ) CAR, pCDCAR1 Human NCAM1/1496 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP5810 Anti-CD56 (NCAM1/1496) h(41BB-CD3ζ) CAR, pCDCAR1 Human NCAM1/1496 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP5811 Anti-CD56 (AF12-7H3) h(CD28-CD3ζ) CAR, pCDCAR1 Human AF12-7H3 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP5812 Anti-CD56 (AF12-7H3) h(41BB-CD3ζ) CAR, pCDCAR1 Human AF12-7H3 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP5813 Anti-CD56 (5tukon56) h(CD28-CD3ζ) CAR, pCDCAR1 Human 5tukon56 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP5814 Anti-CD56 (5tukon56) h(41BB-CD3ζ) CAR, pCDCAR1 Human 5tukon56 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP5815 Anti-CD56 (5E563) h(CD28-CD3ζ) CAR, pCDCAR1 Human 5E563 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP5869 Anti-CD56 (4d) h(CD28-CD3ζ) CAR, pCDCAR1 Human 4d Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP5870 Anti-CD56 (4d) h(41BB-CD3ζ) CAR, pCDCAR1 Human 4d Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP5871 Anti-CD56 (12E4) h(CD28-CD3ζ) CAR, pCDCAR1 Human 12E4 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP5872 Anti-CD56 (12E4) h(41BB-CD3ζ) CAR, pCDCAR1 Human 12E4 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP5873 Anti-CD56 (DS2372AB) h(CD28-CD3ζ) CAR, pCDCAR1 Human DS2372AB Rabbit scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP5874 Anti-CD56 (DS2372AB) h(41BB-CD3ζ) CAR, pCDCAR1 Human DS2372AB Rabbit scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet

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