Anti-CD56 CAR Products - Creative Biolabs

CD56

Neural cell adhesion molecule (NCAM), also called CD56, is a homophilic binding glycoprotein expressed on the surface of neurons, glia, skeletal muscle and natural killer cells. NCAM has been implicated as having a role in cell–cell adhesion, neurite outgrowth, synaptic plasticity, and learning and memory. NCAM is thought to signal to induce neurite outgrowth via the fibroblast growth factor receptor (FGFR) and act upon the p59Fyn signaling pathway. Tumors that are CD56-positive are myeloma, myeloid leukemia, neuroendocrine tumors, Wilms' tumor, neuroblastoma, NK/T cell lymphomas, pancreatic acinar cell carcinoma, pheochromocytoma, paraganglioma, small cell lung carcinoma, and the Ewing's sarcoma family of tumors. NCAM has been used as a target molecule for experimental antibody-based immunotherapy. Successful radioimmunolocalisation of metastases was demonstrated after giving injections of NCAM-binding 123J-UJ13a or 131J-UJ13a radioimmunoconjugates to children with neuroblastoma. Patients with small cell lung cancer were treated with the anti-NCAM immunotoxine huN901-DM1 in two different clinical studies, revealing acceptable toxicity and signs of clinical response.

Associated Disease

Relapsed refractory myeloma
Melanoma

Vector Products
Viral Particles

CAR Vector Products Product list:

Catalog	Targeting Cell Type	Generation	Antibody Clone	Vector Length	Vector Type	Vector Design	Antibody Host	Data sheet	Price
CAR-T-1-M312-2	T cell	First	N901	8kb	Lentiviral	scFv-CD28	Mouse		Inquiry
CAR-T-1-M312-G	T cell	First	N901	8kb	Lentiviral	scFv-FcεRIγ	Mouse		Inquiry
CAR-T-1-M312-Z	T cell	First	N901	8kb	Lentiviral	scFv-CD3ζ	Mouse		Inquiry
CAR-T-2-M312-2G	T cell	Second	N901	8kb	Lentiviral	scFv-CD28-FcεRIγ	Mouse		Inquiry
CAR-T-2-M312-2Z	T cell	Second	N901	8kb	Lentiviral	scFv-CD28-CD3ζ	Mouse		Inquiry
CAR-T-2-M312-4G	T cell	Second	N901	8kb	Lentiviral	scFv-CD4-FcεRIγ	Mouse		Inquiry
CAR-T-2-M312-4Z	T cell	Second	N901	8kb	Lentiviral	scFv-CD4-CD3ζ	Mouse		Inquiry
CAR-T-2-M312-8Z	T cell	Second	N901	8kb	Lentiviral	scFv-CD8-CD3ζ	Mouse		Inquiry
CAR-T-2-M312-BZ	T cell	Second	N901	8kb	Lentiviral	scFv-41BB-CD3ζ	Mouse		Inquiry
CAR-T-2-M312-CZ	T cell	Second	N901	8kb	Lentiviral	scFv-b2c-CD3ζ	Mouse		Inquiry
CAR-T-3-M312-2BZ	T cell	Third	N901	8kb	Lentiviral	scFv-CD28-41BB-CD3ζ	Mouse		Inquiry
CAR-T-3-M312-2XZ	T cell	Third	N901	8kb	Lentiviral	scFv-CD28-OX40-CD3ζ	Mouse		Inquiry
CAR-ZP124	T cell	Second	N901	~8kb	Lentiviral vector	scFv-CD28-CD3ζ	Mouse		Inquiry
CAR-ZP125	T cell	Second	N901	~8kb	Lentiviral vector	scFv-4-1BB-CD3ζ	Mouse		Inquiry
CAR-ZP314	NK cell	Second	S	~8kb	Lentiviral vector	scFv-CD28-CD3ζ	Humanized		Inquiry
CAR-ZP315	NK cell	Second	S	~8kb	Lentiviral vector	scFv-4-1BB-CD3ζ	Humanized		Inquiry

CAR Viral Particles Product list:

Catalog	Antibody Clone	Packaging System	Generation	Gene Construct	Promotor	Packaging Cell	Titer	Data sheet	Price
VP-CAR-LC389	N901	Lentivirus	First	scFv (N901)-CD28	EF1a	293T	> 10⁷ IFU/ml		Inquiry
VP-CAR-LC390	N901	Lentivirus	First	scFv (N901)-FcεRIγ	EF1a	293T	> 10⁷ IFU/ml		Inquiry
VP-CAR-LC391	N901	Lentivirus	First	scFv (N901)-CD3ζ	EF1a	293T	> 10⁷ IFU/ml		Inquiry
VP-CAR-LC392	N901	Lentivirus	Second	scFv (N901)-CD28-FcεRIγ	EF1a	293T	> 10⁷ IFU/ml		Inquiry
VP-CAR-LC393	N901	Lentivirus	Second	scFv (N901)-CD28-CD3ζ	EF1a	293T	> 10⁷ IFU/ml		Inquiry
VP-CAR-LC394	N901	Lentivirus	Second	scFv (N901)-CD4-FcεRIγ	EF1a	293T	> 10⁷ IFU/ml		Inquiry
VP-CAR-LC395	N901	Lentivirus	Second	scFv (N901)-CD4-CD3ζ	EF1a	293T	> 10⁷ IFU/ml		Inquiry
VP-CAR-LC396	N901	Lentivirus	Second	scFv (N901)-CD8-CD3ζ	EF1a	293T	> 10⁷ IFU/ml		Inquiry
VP-CAR-LC397	N901	Lentivirus	Second	scFv (N901)-41BB-CD3ζ	EF1a	293T	> 10⁷ IFU/ml		Inquiry
VP-CAR-LC398	N901	Lentivirus	Second	scFv (N901)-b2c-CD3ζ	EF1a	293T	> 10⁷ IFU/ml		Inquiry
VP-CAR-LC399	N901	Lentivirus	Third	scFv (N901)-CD28-41BB-CD3ζ	EF1a	293T	> 10⁷ IFU/ml		Inquiry
VP-CAR-LC400	N901	Lentivirus	Third	scFv (N901)-CD28-OX40-CD3ζ	EF1a	293T	> 10⁷ IFU/ml		Inquiry

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