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CD56

Neural cell adhesion molecule (NCAM), also called CD56, is a homophilic binding glycoprotein expressed on the surface of neurons, glia, skeletal muscle and natural killer cells. NCAM has been implicated as having a role in cell–cell adhesion, neurite outgrowth, synaptic plasticity, and learning and memory. NCAM is thought to signal to induce neurite outgrowth via the fibroblast growth factor receptor (FGFR) and act upon the p59Fyn signaling pathway. Tumors that are CD56-positive are myeloma, myeloid leukemia, neuroendocrine tumors, Wilms' tumor, neuroblastoma, NK/T cell lymphomas, pancreatic acinar cell carcinoma, pheochromocytoma, paraganglioma, small cell lung carcinoma, and the Ewing's sarcoma family of tumors. NCAM has been used as a target molecule for experimental antibody-based immunotherapy. Successful radioimmunolocalisation of metastases was demonstrated after giving injections of NCAM-binding 123J-UJ13a or 131J-UJ13a radioimmunoconjugates to children with neuroblastoma. Patients with small cell lung cancer were treated with the anti-NCAM immunotoxine huN901-DM1 in two different clinical studies, revealing acceptable toxicity and signs of clinical response.

Associated Disease
  • Relapsed refractory myeloma
  • Melanoma
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  • CAR Viral Particles
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CAT Product Name Target Species Antibody Clone Antibody Host Receptor Construction Vector Type Targeting Cell Type Inquiry & Datasheet
CAR-ZP5836 Anti-CD56 (3G12) h(41BB-CD3ζ) CAR, pCDCAR1 Human 3G12 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP5837 Anti-CD56 (321CT11.4.4) h(CD28-CD3ζ) CAR, pCDCAR1 Human 321CT11.4.4 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP5838 Anti-CD56 (321CT11.4.4) h(41BB-CD3ζ) CAR, pCDCAR1 Human 321CT11.4.4 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP5839 Anti-CD56 (2D4) h(CD28-CD3ζ) CAR, pCDCAR1 Human 2D4 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP5840 Anti-CD56 (2D4) h(41BB-CD3ζ) CAR, pCDCAR1 Human 2D4 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP5841 Anti-CD56 (2A2) h(CD28-CD3ζ) CAR, pCDCAR1 Human 2A2 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP5842 Anti-CD56 (2A2) h(41BB-CD3ζ) CAR, pCDCAR1 Human 2A2 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP5843 Anti-CD56 (1G4) h(CD28-CD3ζ) CAR, pCDCAR1 Human 1G4 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP5844 Anti-CD56 (1G4) h(41BB-CD3ζ) CAR, pCDCAR1 Human 1G4 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP5845 Anti-CD56 (1C7) h(CD28-CD3ζ) CAR, pCDCAR1 Human 1C7 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP5846 Anti-CD56 (1C7) h(41BB-CD3ζ) CAR, pCDCAR1 Human 1C7 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP5847 Anti-CD56 (1A3) h(CD28-CD3ζ) CAR, pCDCAR1 Human 1A3 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP5848 Anti-CD56 (1A3) h(41BB-CD3ζ) CAR, pCDCAR1 Human 1A3 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP5849 Anti-CD56 (1213C3.D5) h(CD28-CD3ζ) CAR, pCDCAR1 Human 1213C3.D5 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP5850 Anti-CD56 (1213C3.D5) h(41BB-CD3ζ) CAR, pCDCAR1 Human 1213C3.D5 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP5851 Anti-CD56 (CDLA56) h(CD28-CD3ζ) CAR, pCDCAR1 Human CDLA56 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP5852 Anti-CD56 (CDLA56) h(41BB-CD3ζ) CAR, pCDCAR1 Human CDLA56 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP5853 Anti-CD56 (C5.9) h(CD28-CD3ζ) CAR, pCDCAR1 Human C5.9 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP5854 Anti-CD56 (C5.9) h(41BB-CD3ζ) CAR, pCDCAR1 Human C5.9 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP5855 Anti-CD56 (B-A19) h(CD28-CD3ζ) CAR, pCDCAR1 Human B-A19 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP5856 Anti-CD56 (B-A19) h(41BB-CD3ζ) CAR, pCDCAR1 Human B-A19 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP5857 Anti-CD56 (56C04) h(CD28-CD3ζ) CAR, pCDCAR1 Human 56C04 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP5858 Anti-CD56 (56C04) h(41BB-CD3ζ) CAR, pCDCAR1 Human 56C04 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP5859 Anti-CD56 (123C3) h(CD28-CD3ζ) CAR, pCDCAR1 Human 123C3 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP5860 Anti-CD56 (123C3) h(41BB-CD3ζ) CAR, pCDCAR1 Human 123C3 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP5861 Anti-CD56 (123A8) h(CD28-CD3ζ) CAR, pCDCAR1 Human 123A8 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP5862 Anti-CD56 (123A8) h(41BB-CD3ζ) CAR, pCDCAR1 Human 123A8 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP5863 Anti-CD56 (5B8) h(CD28-CD3ζ) CAR, pCDCAR1 Human 5B8 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP5864 Anti-CD56 (5B8) h(41BB-CD3ζ) CAR, pCDCAR1 Human 5B8 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP5865 Anti-CD56 (5A5) h(CD28-CD3ζ) CAR, pCDCAR1 Human 5A5 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP5866 Anti-CD56 (5A5) h(41BB-CD3ζ) CAR, pCDCAR1 Human 5A5 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP5867 Anti-CD56 (5.1H11) h(CD28-CD3ζ) CAR, pCDCAR1 Human 5.1H11 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP5868 Anti-CD56 (5.1H11) h(41BB-CD3ζ) CAR, pCDCAR1 Human 5.1H11 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP5871 Anti-CD56 (12E4) h(CD28-CD3ζ) CAR, pCDCAR1 Human 12E4 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP5872 Anti-CD56 (12E4) h(41BB-CD3ζ) CAR, pCDCAR1 Human 12E4 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP5873 Anti-CD56 (DS2372AB) h(CD28-CD3ζ) CAR, pCDCAR1 Human DS2372AB Rabbit scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP5874 Anti-CD56 (DS2372AB) h(41BB-CD3ζ) CAR, pCDCAR1 Human DS2372AB Rabbit scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP5875 Anti-CD56 (TH59DS) h(CD28-CD3ζ) CAR, pCDCAR1 Human TH59DS Rabbit scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP5876 Anti-CD56 (TH59DS) h(41BB-CD3ζ) CAR, pCDCAR1 Human TH59DS Rabbit scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP5877 Anti-CD56 (CBPCN-138) h(CD28-CD3ζ) CAR, pCDCAR1 Human CBPCN-138 Rabbit scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet

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