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CD56

Neural cell adhesion molecule (NCAM), also called CD56, is a homophilic binding glycoprotein expressed on the surface of neurons, glia, skeletal muscle and natural killer cells. NCAM has been implicated as having a role in cell–cell adhesion, neurite outgrowth, synaptic plasticity, and learning and memory. NCAM is thought to signal to induce neurite outgrowth via the fibroblast growth factor receptor (FGFR) and act upon the p59Fyn signaling pathway. Tumors that are CD56-positive are myeloma, myeloid leukemia, neuroendocrine tumors, Wilms' tumor, neuroblastoma, NK/T cell lymphomas, pancreatic acinar cell carcinoma, pheochromocytoma, paraganglioma, small cell lung carcinoma, and the Ewing's sarcoma family of tumors. NCAM has been used as a target molecule for experimental antibody-based immunotherapy. Successful radioimmunolocalisation of metastases was demonstrated after giving injections of NCAM-binding 123J-UJ13a or 131J-UJ13a radioimmunoconjugates to children with neuroblastoma. Patients with small cell lung cancer were treated with the anti-NCAM immunotoxine huN901-DM1 in two different clinical studies, revealing acceptable toxicity and signs of clinical response.

Associated Disease
  • Relapsed refractory myeloma
  • Melanoma

CAR Vector Products Product list:

Catalog Targeting
Cell Type 		Generation Antibody
Clone 		Vector
Length 		Vector
Type 		Vector Design Antibody
Host 		Data
sheet		 Price
CAR-T-1-M312-2 T cell First N901 8kb Lentiviral scFv-CD28 Mouse Inquiry
CAR-T-1-M312-G T cell First N901 8kb Lentiviral scFv-FcεRIγ Mouse Inquiry
CAR-T-1-M312-Z T cell First N901 8kb Lentiviral scFv-CD3ζ Mouse Inquiry
CAR-T-2-M312-2G T cell Second N901 8kb Lentiviral scFv-CD28-FcεRIγ Mouse Inquiry
CAR-T-2-M312-2Z T cell Second N901 8kb Lentiviral scFv-CD28-CD3ζ Mouse Inquiry
CAR-T-2-M312-4G T cell Second N901 8kb Lentiviral scFv-CD4-FcεRIγ Mouse Inquiry
CAR-T-2-M312-4Z T cell Second N901 8kb Lentiviral scFv-CD4-CD3ζ Mouse Inquiry
CAR-T-2-M312-8Z T cell Second N901 8kb Lentiviral scFv-CD8-CD3ζ Mouse Inquiry
CAR-T-2-M312-BZ T cell Second N901 8kb Lentiviral scFv-41BB-CD3ζ Mouse Inquiry
CAR-T-2-M312-CZ T cell Second N901 8kb Lentiviral scFv-b2c-CD3ζ Mouse Inquiry
CAR-T-3-M312-2BZ T cell Third N901 8kb Lentiviral scFv-CD28-41BB-CD3ζ Mouse Inquiry
CAR-T-3-M312-2XZ T cell Third N901 8kb Lentiviral scFv-CD28-OX40-CD3ζ Mouse Inquiry

CAR Viral Particles Product list:

Catalog Antibody
Clone 		Packaging
System 		Generation Gene
Construct 		Promotor Packaging
Cell 		Titer Data
sheet		 Price
VP-CAR-LC389 N901 Lentivirus First scFv (N901)-CD28 CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC390 N901 Lentivirus First scFv (N901)-FcεRIγ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC391 N901 Lentivirus First scFv (N901)-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC392 N901 Lentivirus Second scFv (N901)-CD28-FcεRIγ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC393 N901 Lentivirus Second scFv (N901)-CD28-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC394 N901 Lentivirus Second scFv (N901)-CD4-FcεRIγ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC395 N901 Lentivirus Second scFv (N901)-CD4-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC396 N901 Lentivirus Second scFv (N901)-CD8-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC397 N901 Lentivirus Second scFv (N901)-41BB-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC398 N901 Lentivirus Second scFv (N901)-b2c-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC399 N901 Lentivirus Third scFv (N901)-CD28-41BB-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC400 N901 Lentivirus Third scFv (N901)-CD28-OX40-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
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