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CD56

Neural cell adhesion molecule (NCAM), also called CD56, is a homophilic binding glycoprotein expressed on the surface of neurons, glia, skeletal muscle and natural killer cells. NCAM has been implicated as having a role in cell–cell adhesion, neurite outgrowth, synaptic plasticity, and learning and memory. NCAM is thought to signal to induce neurite outgrowth via the fibroblast growth factor receptor (FGFR) and act upon the p59Fyn signaling pathway. Tumors that are CD56-positive are myeloma, myeloid leukemia, neuroendocrine tumors, Wilms' tumor, neuroblastoma, NK/T cell lymphomas, pancreatic acinar cell carcinoma, pheochromocytoma, paraganglioma, small cell lung carcinoma, and the Ewing's sarcoma family of tumors. NCAM has been used as a target molecule for experimental antibody-based immunotherapy. Successful radioimmunolocalisation of metastases was demonstrated after giving injections of NCAM-binding 123J-UJ13a or 131J-UJ13a radioimmunoconjugates to children with neuroblastoma. Patients with small cell lung cancer were treated with the anti-NCAM immunotoxine huN901-DM1 in two different clinical studies, revealing acceptable toxicity and signs of clinical response.

Associated Disease
  • Relapsed refractory myeloma
  • Melanoma
  • CAR Vector Products
  • CAR Viral Particles
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CAT Product Name Target SpeciesAntibody CloneAntibody HostReceptor ConstructionVector TypeTargeting Cell Type Inquiry & Datasheet
CAR-ZP5795 Anti-CD56 (NCAM16) h(CD28-CD3ζ) CAR, pCDCAR1 Human NCAM16 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP5796 Anti-CD56 (NCAM16) h(41BB-CD3ζ) CAR, pCDCAR1 Human NCAM16 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP5797 Anti-CD56 (MY31) h(CD28-CD3ζ) CAR, pCDCAR1 Human MY31 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP5798 Anti-CD56 (MY31) h(41BB-CD3ζ) CAR, pCDCAR1 Human MY31 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP5799 Anti-CD56 (5F303) h(CD28-CD3ζ) CAR, pCDCAR1 Human 5F303 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP5800 Anti-CD56 (5F303) h(41BB-CD3ζ) CAR, pCDCAR1 Human 5F303 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP5801 Anti-CD56 (14L223) h(CD28-CD3ζ) CAR, pCDCAR1 Human 14L223 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP5802 Anti-CD56 (14L223) h(41BB-CD3ζ) CAR, pCDCAR1 Human 14L223 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP5814 Anti-CD56 (5tukon56) h(41BB-CD3ζ) CAR, pCDCAR1 Human 5tukon56 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP5815 Anti-CD56 (5E563) h(CD28-CD3ζ) CAR, pCDCAR1 Human 5E563 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP5816 Anti-CD56 (5E563) h(41BB-CD3ζ) CAR, pCDCAR1 Human 5E563 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP5817 Anti-CD56 (3F97) h(CD28-CD3ζ) CAR, pCDCAR1 Human 3F97 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP5818 Anti-CD56 (3F97) h(41BB-CD3ζ) CAR, pCDCAR1 Human 3F97 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP5819 Anti-CD56 (2Q692) h(CD28-CD3ζ) CAR, pCDCAR1 Human 2Q692 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP5820 Anti-CD56 (2Q692) h(41BB-CD3ζ) CAR, pCDCAR1 Human 2Q692 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP5821 Anti-CD56 (3H1571) h(CD28-CD3ζ) CAR, pCDCAR1 Human 3H1571 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP5822 Anti-CD56 (3H1571) h(41BB-CD3ζ) CAR, pCDCAR1 Human 3H1571 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP5823 Anti-CD56 (123C3.D5) h(CD28-CD3ζ) CAR, pCDCAR1 Human 123C3.D5 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP5824 Anti-CD56 (123C3.D5) h(41BB-CD3ζ) CAR, pCDCAR1 Human 123C3.D5 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP5825 Anti-CD56 (10B1827) h(CD28-CD3ζ) CAR, pCDCAR1 Human 10B1827 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP5826 Anti-CD56 (10B1827) h(41BB-CD3ζ) CAR, pCDCAR1 Human 10B1827 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP5829 Anti-CD56 (5F27) h(CD28-CD3ζ) CAR, pCDCAR1 Human 5F27 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP5830 Anti-CD56 (5F27) h(41BB-CD3ζ) CAR, pCDCAR1 Human 5F27 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP5831 Anti-CD56 (4A123C3) h(CD28-CD3ζ) CAR, pCDCAR1 Human 4A123C3 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP5832 Anti-CD56 (4A123C3) h(41BB-CD3ζ) CAR, pCDCAR1 Human 4A123C3 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP5833 Anti-CD56 (3H2) h(CD28-CD3ζ) CAR, pCDCAR1 Human 3H2 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP5834 Anti-CD56 (3H2) h(41BB-CD3ζ) CAR, pCDCAR1 Human 3H2 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP5835 Anti-CD56 (3G12) h(CD28-CD3ζ) CAR, pCDCAR1 Human 3G12 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP5836 Anti-CD56 (3G12) h(41BB-CD3ζ) CAR, pCDCAR1 Human 3G12 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP5837 Anti-CD56 (321CT11.4.4) h(CD28-CD3ζ) CAR, pCDCAR1 Human 321CT11.4.4 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP5838 Anti-CD56 (321CT11.4.4) h(41BB-CD3ζ) CAR, pCDCAR1 Human 321CT11.4.4 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP5839 Anti-CD56 (2D4) h(CD28-CD3ζ) CAR, pCDCAR1 Human 2D4 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP5840 Anti-CD56 (2D4) h(41BB-CD3ζ) CAR, pCDCAR1 Human 2D4 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP5841 Anti-CD56 (2A2) h(CD28-CD3ζ) CAR, pCDCAR1 Human 2A2 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP5842 Anti-CD56 (2A2) h(41BB-CD3ζ) CAR, pCDCAR1 Human 2A2 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP5843 Anti-CD56 (1G4) h(CD28-CD3ζ) CAR, pCDCAR1 Human 1G4 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP5844 Anti-CD56 (1G4) h(41BB-CD3ζ) CAR, pCDCAR1 Human 1G4 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP5890 Anti-CD56 (H28-123) h(41BB-CD3ζ) CAR, pCDCAR1 Human H28-123 Rat scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP5891 Anti-CD56 (12F8) h(CD28-CD3ζ) CAR, pCDCAR1 Human 12F8 Rat scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP5892 Anti-CD56 (12F8) h(41BB-CD3ζ) CAR, pCDCAR1 Human 12F8 Rat scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet

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