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CD56

Neural cell adhesion molecule (NCAM), also called CD56, is a homophilic binding glycoprotein expressed on the surface of neurons, glia, skeletal muscle and natural killer cells. NCAM has been implicated as having a role in cell–cell adhesion, neurite outgrowth, synaptic plasticity, and learning and memory. NCAM is thought to signal to induce neurite outgrowth via the fibroblast growth factor receptor (FGFR) and act upon the p59Fyn signaling pathway. Tumors that are CD56-positive are myeloma, myeloid leukemia, neuroendocrine tumors, Wilms' tumor, neuroblastoma, NK/T cell lymphomas, pancreatic acinar cell carcinoma, pheochromocytoma, paraganglioma, small cell lung carcinoma, and the Ewing's sarcoma family of tumors. NCAM has been used as a target molecule for experimental antibody-based immunotherapy. Successful radioimmunolocalisation of metastases was demonstrated after giving injections of NCAM-binding 123J-UJ13a or 131J-UJ13a radioimmunoconjugates to children with neuroblastoma. Patients with small cell lung cancer were treated with the anti-NCAM immunotoxine huN901-DM1 in two different clinical studies, revealing acceptable toxicity and signs of clinical response.

Associated Disease
  • Relapsed refractory myeloma
  • Melanoma
  • CAR Vector Products
  • CAR Viral Particles
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CAT Product Name Target SpeciesAntibody CloneAntibody HostReceptor ConstructionVector TypeTargeting Cell Type Inquiry & Datasheet
CAR-ZP124 Anti-CD56 (N901) h(CD28-CD3ζ) CAR, pCDCAR1 Human N901 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP314 Anti-CD56 (S) h(CD28-CD3ζ) CAR, pCDCAR1 Human S Humanized scFv-CD28-CD3ζ Lentiviral vector NK cell   Add to Cart   Datasheet
CAR-ZP5773 Anti-CD56 (124D4) h(CD28-CD3ζ) CAR, pCDCAR1 Human 124D4 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP125 Anti-CD56 (N901) h(41BB-CD3ζ) CAR, pCDCAR1 Human N901 Mouse scFv-4-1BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP5811 Anti-CD56 (AF12-7H3) h(CD28-CD3ζ) CAR, pCDCAR1 Human AF12-7H3 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP315 Anti-CD56 (S) h(41BB-CD3ζ) CAR, pCDCAR1 Human S Humanized scFv-4-1BB-CD3ζ Lentiviral vector NK cell   Add to Cart   Datasheet
CAR-ZP5877 Anti-CD56 (CBPCN-138) h(CD28-CD3ζ) CAR, pCDCAR1 Human CBPCN-138 Rabbit scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP5774 Anti-CD56 (124D4) h(41BB-CD3ζ) CAR, pCDCAR1 Human 124D4 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP5775 Anti-CD56 (5A2) h(CD28-CD3ζ) CAR, pCDCAR1 Human 5A2 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP5812 Anti-CD56 (AF12-7H3) h(41BB-CD3ζ) CAR, pCDCAR1 Human AF12-7H3 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP5813 Anti-CD56 (5tukon56) h(CD28-CD3ζ) CAR, pCDCAR1 Human 5tukon56 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP5776 Anti-CD56 (5A2) h(41BB-CD3ζ) CAR, pCDCAR1 Human 5A2 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP5777 Anti-CD56 (HCD56) h(CD28-CD3ζ) CAR, pCDCAR1 Human HCD56 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP5878 Anti-CD56 (CBPCN-138) h(41BB-CD3ζ) CAR, pCDCAR1 Human CBPCN-138 Rabbit scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP5879 Anti-CD56 (JF1021) h(CD28-CD3ζ) CAR, pCDCAR1 Human JF1021 Rabbit scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP5814 Anti-CD56 (5tukon56) h(41BB-CD3ζ) CAR, pCDCAR1 Human 5tukon56 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP5815 Anti-CD56 (5E563) h(CD28-CD3ζ) CAR, pCDCAR1 Human 5E563 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP5778 Anti-CD56 (HCD56) h(41BB-CD3ζ) CAR, pCDCAR1 Human HCD56 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP5779 Anti-CD56 (NCAM1/784) h(CD28-CD3ζ) CAR, pCDCAR1 Human NCAM1/784 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP5816 Anti-CD56 (5E563) h(41BB-CD3ζ) CAR, pCDCAR1 Human 5E563 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP5817 Anti-CD56 (3F97) h(CD28-CD3ζ) CAR, pCDCAR1 Human 3F97 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP5818 Anti-CD56 (3F97) h(41BB-CD3ζ) CAR, pCDCAR1 Human 3F97 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP5819 Anti-CD56 (2Q692) h(CD28-CD3ζ) CAR, pCDCAR1 Human 2Q692 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP5820 Anti-CD56 (2Q692) h(41BB-CD3ζ) CAR, pCDCAR1 Human 2Q692 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP5821 Anti-CD56 (3H1571) h(CD28-CD3ζ) CAR, pCDCAR1 Human 3H1571 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP5822 Anti-CD56 (3H1571) h(41BB-CD3ζ) CAR, pCDCAR1 Human 3H1571 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP5823 Anti-CD56 (123C3.D5) h(CD28-CD3ζ) CAR, pCDCAR1 Human 123C3.D5 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP5824 Anti-CD56 (123C3.D5) h(41BB-CD3ζ) CAR, pCDCAR1 Human 123C3.D5 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP5825 Anti-CD56 (10B1827) h(CD28-CD3ζ) CAR, pCDCAR1 Human 10B1827 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP5826 Anti-CD56 (10B1827) h(41BB-CD3ζ) CAR, pCDCAR1 Human 10B1827 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP5829 Anti-CD56 (5F27) h(CD28-CD3ζ) CAR, pCDCAR1 Human 5F27 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP5830 Anti-CD56 (5F27) h(41BB-CD3ζ) CAR, pCDCAR1 Human 5F27 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP5831 Anti-CD56 (4A123C3) h(CD28-CD3ζ) CAR, pCDCAR1 Human 4A123C3 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP5780 Anti-CD56 (NCAM1/784) h(41BB-CD3ζ) CAR, pCDCAR1 Human NCAM1/784 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP5781 Anti-CD56 (T199) h(CD28-CD3ζ) CAR, pCDCAR1 Human T199 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP5782 Anti-CD56 (T199) h(41BB-CD3ζ) CAR, pCDCAR1 Human T199 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP5783 Anti-CD56 (NCAM1/795) h(CD28-CD3ζ) CAR, pCDCAR1 Human NCAM1/795 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP5832 Anti-CD56 (4A123C3) h(41BB-CD3ζ) CAR, pCDCAR1 Human 4A123C3 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP5833 Anti-CD56 (3H2) h(CD28-CD3ζ) CAR, pCDCAR1 Human 3H2 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP5834 Anti-CD56 (3H2) h(41BB-CD3ζ) CAR, pCDCAR1 Human 3H2 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet

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