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EXPLORE MORE HighlightsThe advent of Chimeric Antigen Receptor T-cell (CAR-T) therapies has revolutionized the field of oncology, providing new avenues for treating various forms of cancer. Our 20 years of experience in the biotechnology sector have equipped us with the expertise and technological capabilities to support the entire lifecycle of CAR-T products, from early development to commercialization.
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The epidermal growth factor receptor (EGFR) belongs to the ErbB family of receptor tyrosine kinases (RTK). These trans-membrane proteins are activated following binding with peptide growth factors of the EGF-family of proteins. Evidence suggests that the EGFR is involved in the pathogenesis and progression of different carcinoma types. The EGFR and EGF-like peptides are often over-expressed in human carcinomas. Mutations that lead to EGFR overexpression (known as upregulation) or overactivity have been associated with a number of cancers, including squamous-cell carcinoma of the lung (80% of cases), anal cancers, glioblastoma (50%) and epithelian tumors of the head and neck (80-100%).
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| CAT | Product Name | Target Species | Antibody Clone | Antibody Host | Receptor Construction | Vector Type | Targeting Cell Type | CAR Vector Type | Inquiry & Datasheet |
| CAR-WFY6635 | Anti-EGFR (CBFYE-0583) h(41BB-CD3ζ) CAR, pCDCAR1 | Human | CBFYE-0583 | Rabbit | scFv-41BB-CD3ζ | Lentiviral vector | T cell | ||
| CAR-WFY6636 | Anti-EGFR (CBFYE-0584) h(41BB-CD3ζ) CAR, pCDCAR1 | Mouse | CBFYE-0584 | Rabbit | scFv-41BB-CD3ζ | Lentiviral vector | T cell | ||
| CAR-WFY6637 | Anti-EGFR (CBFYE-0585) h(41BB-CD3ζ) CAR, pCDCAR1 | Rat | CBFYE-0585 | Rabbit | scFv-41BB-CD3ζ | Lentiviral vector | T cell | ||
| CAR-WFY6638 | Anti-EGFR (CBFYE-0586) h(41BB-CD3ζ) CAR, pCDCAR1 | Human | CBFYE-0586 | Mouse | scFv-41BB-CD3ζ | Lentiviral vector | T cell | ||
| CAR-WFY6639 | Anti-EGFR (CBFYE-0587) h(41BB-CD3ζ) CAR, pCDCAR1 | Human, Rat, Mouse | CBFYE-0587 | Mouse | scFv-41BB-CD3ζ | Lentiviral vector | T cell | ||
| CAR-WFY6640 | Anti-EGFR (CBFYE-0588) h(41BB-CD3ζ) CAR, pCDCAR1 | D. melanogaster | CBFYE-0588 | Mouse | scFv-41BB-CD3ζ | Lentiviral vector | T cell | ||
| CAR-WFY6641 | Anti-EGFR (CBFYE-0589) h(41BB-CD3ζ) CAR, pCDCAR1 | Mouse | CBFYE-0589 | Rat | scFv-41BB-CD3ζ | Lentiviral vector | T cell | ||
| CAR-WFY6642 | Anti-EGFR (CBFYE-0590) h(41BB-CD3ζ) CAR, pCDCAR1 | Human | CBFYE-0590 | Mouse | scFv-41BB-CD3ζ | Lentiviral vector | T cell | ||
| CAR-WFY6643 | Anti-EGFR (CBFYE-0591) h(41BB-CD3ζ) CAR, pCDCAR1 | Human, Mouse | CBFYE-0591 | Mouse | scFv-41BB-CD3ζ | Lentiviral vector | T cell | ||
| CAR-WFY6644 | Anti-EGFR (CBFYE-0592) h(41BB-CD3ζ) CAR, pCDCAR1 | Dog, Human, Mouse | CBFYE-0592 | Mouse | scFv-41BB-CD3ζ | Lentiviral vector | T cell | ||
| CAR-WFY6645 | Anti-EGFR (CBFYE-0593) h(41BB-CD3ζ) CAR, pCDCAR1 | Dog, Human, Mouse, Rat | CBFYE-0593 | Mouse | scFv-41BB-CD3ζ | Lentiviral vector | T cell | ||
| CAR-WFY6646 | Anti-EGFR (CBFYE-0594) h(41BB-CD3ζ) CAR, pCDCAR1 | Human | CBFYE-0594 | Mouse | scFv-41BB-CD3ζ | Lentiviral vector | T cell | ||
| CAR-WFY6647 | Anti-EGFR (CBFYE-0595) h(41BB-CD3ζ) CAR, pCDCAR1 | Human | CBFYE-0595 | Mouse | scFv-41BB-CD3ζ | Lentiviral vector | T cell | ||
| CAR-WFY6648 | Anti-EGFR (CBFYE-0596) h(41BB-CD3ζ) CAR, pCDCAR1 | Human | CBFYE-0596 | Rabbit | scFv-41BB-CD3ζ | Lentiviral vector | T cell | ||
| CAR-WFY6649 | Anti-EGFR (CBFYE-0597) h(41BB-CD3ζ) CAR, pCDCAR1 | Human, Mouse | CBFYE-0597 | Mouse | scFv-41BB-CD3ζ | Lentiviral vector | T cell | ||
| CAR-WFY6650 | Anti-EGFR (CBFYE-0598) h(41BB-CD3ζ) CAR, pCDCAR1 | Human | CBFYE-0598 | Rabbit | scFv-41BB-CD3ζ | Lentiviral vector | T cell | ||
| CAR-WFY6651 | Anti-EGFR (CBFYE-0599) h(41BB-CD3ζ) CAR, pCDCAR1 | Human | CBFYE-0599 | Mouse | scFv-41BB-CD3ζ | Lentiviral vector | T cell | ||
| CAR-WFY6652 | Anti-EGFR (CBFYE-0600) h(41BB-CD3ζ) CAR, pCDCAR1 | Human | CBFYE-0600 | Mouse | scFv-41BB-CD3ζ | Lentiviral vector | T cell | ||
| CAR-WFY6653 | Anti-EGFR (CBFYE-0601) h(41BB-CD3ζ) CAR, pCDCAR1 | Human | CBFYE-0601 | Mouse | scFv-41BB-CD3ζ | Lentiviral vector | T cell | ||
| CAR-ZP8476 | A uniCAR [Anti-FITC CAR], with a mAb-based CAR Adaptor [Anti-EGFR (Cetuximab)], a Switchable CAR System | Breast cancer | Lentiviral vector | ||||||
| CAR-ZP8493 | A uniCAR [Anti-CD16 CAR], with a mAb-based CAR Adaptor [Anti-EGFR (Cetuximab)], a Switchable CAR System | Breast cancer | Lentiviral vector | ||||||
| CAR-ZP8494 | A uniCAR [Anti-CD16 CAR], with a mAb-based CAR Adaptor [Anti-EGFR (Panitumumab)], a Switchable CAR System | Breast cancer | Lentiviral vector | ||||||
| CAR-SB-LX0203 | Anti-EGFR (Modotuximab) h(CD28-CD3ζ) CAR, pSBCAR1 | Human | Modotuximab | Mouse | scFv-CD28-CD3ζ | Sleeping Beauty (SB) transposon | T cell |
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CellRapeutics™ In Vivo Cell Engineering: One-stop in vivo T/B/NK cell and macrophage engineering services covering vectors construction to function verification.
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Silence™ CAR-T Cell: A novel platform to enhance CAR-T cell immunotherapy by combining RNAi technology to suppress genes that may impede CAR functionality.
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Canine CAR-T Therapy Development: From early target discovery, CAR design and construction, cell culture, and transfection, to in vitro and in vivo function validation.
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