EGFR

The epidermal growth factor receptor (EGFR) belongs to the ErbB family of receptor tyrosine kinases (RTK). These trans-membrane proteins are activated following binding with peptide growth factors of the EGF-family of proteins. Evidence suggests that the EGFR is involved in the pathogenesis and progression of different carcinoma types. The EGFR and EGF-like peptides are often over-expressed in human carcinomas. Mutations that lead to EGFR overexpression (known as upregulation) or overactivity have been associated with a number of cancers, including squamous-cell carcinoma of the lung (80% of cases), anal cancers, glioblastoma (50%) and epithelian tumors of the head and neck (80-100%).

Associated Disease

CAR Vector Products Product list:

Catalog Targeting
Cell Type
Generation Antibody
Clone
Vector
Length
Vector
Type
Vector Design Antibody
Host
Data
sheet
Price
CAR-LC097 T cell First 806 ~8kb Lentiviral scFv-CD3ζ Human Inquiry
CAR-LC098 T cell Second 806 ~8kb Lentiviral scFv-CD28-CD3ζ Human Inquiry
CAR-LC099 T cell Second 806 ~8kb Lentiviral scFv-41BB-CD3ζ Human Inquiry
CAR-LC100 T cell Third 806 ~8kb Lentiviral scFv-CD28-41BB-CD3ζ Human Inquiry
CAR-LC127 NK cell Second Cetuximab ~8kb Lentiviral scFv-41BB-CD3ζ Human Inquiry
CAR-LC198 T cell Second Cetuximab ~8kb Lentiviral scFv-CD28-CD3ζ Mouse Inquiry
CAR-LC376 T cell First ~8kb Retroviral scFv-CD3ζ-GITR Human Inquiry
CAR-LC377 T cell Second ~8kb Retroviral scFv-CD28-CD3ζ-GITR Human Inquiry
CAR-LC378 T cell Second ~8kb Retroviral scFv-GITR-CD28-CD3ζ Human Inquiry
CAR-MZ005 T cell First Cetuximab ~8kb Lentiviral scFv-CD3ζ Human/mouse chimeric Inquiry
CAR-MZ007 T cell Second Cetuximab ~8kb Lentiviral scFv-41BB-CD3ζ Human/mouse chimeric Inquiry
CAR-MZ008 T cell Third Cetuximab ~8kb Lentiviral scFv-CD28-41BB-CD3ζ Human/mouse chimeric Inquiry
CAR-MZ009 T cell First Nimotuzumab ~8kb Lentiviral scFv-CD3ζ Humanized Inquiry
CAR-MZ010 T cell Second Nimotuzumab ~8kb Lentiviral scFv-CD28-CD3ζ Humanized Inquiry
CAR-MZ011 T cell Second Nimotuzumab ~8kb Lentiviral scFv-41BB-CD3ζ Humanized Inquiry
CAR-MZ012 T cell Third Nimotuzumab ~8kb Lentiviral scFv-CD28-41BB-CD3ζ Humanized Inquiry
CAR-MZ163 NK cell First R1 ~8kb Lentiviral scFv-CD3ζ Mouse Inquiry
CAR-MZ164 NK cell Second R1 ~8kb Lentiviral scFv-41BB-CD3ζ Mouse Inquiry
CAR-MZ165 NK cell Second R1 ~8kb Lentiviral scFv-CD28-CD3ζ Mouse Inquiry
CAR-T-1-L338-2 T cell First 8kb Lentiviral scFv-CD28 Human Inquiry
CAR-T-1-L338-G T cell First 8kb Lentiviral scFv-FcεRIγ Human Inquiry
CAR-T-1-L338-Z T cell First 8kb Lentiviral scFv-CD3ζ Human Inquiry
CAR-T-2-L338-2G T cell Second 8kb Lentiviral scFv-CD28-FcεRIγ Human Inquiry
CAR-T-2-L338-2Z T cell Second 8kb Lentiviral scFv-CD28-CD3ζ Human Inquiry
CAR-T-2-L338-4G T cell Second 8kb Lentiviral scFv-CD4-FcεRIγ Human Inquiry
CAR-T-2-L338-4Z T cell Second 8kb Lentiviral scFv-CD4-CD3ζ Human Inquiry
CAR-T-2-L338-8Z T cell Second 8kb Lentiviral scFv-CD8-CD3ζ Human Inquiry
CAR-T-2-L338-BZ T cell Second 8kb Lentiviral scFv-41BB-CD3ζ Human Inquiry
CAR-T-2-L338-CZ T cell Second 8kb Lentiviral scFv-b2c-CD3ζ Human Inquiry
CAR-T-3-L338-2BZ T cell Third 8kb Lentiviral scFv-CD28-41BB-CD3ζ Human Inquiry
CAR-T-3-L338-2XZ T cell Third 8kb Lentiviral scFv-CD28-OX40-CD3ζ Human Inquiry

CAR Viral Particles Product list:

Catalog Antibody
Clone
Packaging
System
Generation Gene
Construct
Promotor Packaging
Cell
Titer Data
sheet
Price
VP-CAR-LC193 Lentivirus First scFv-CD28 CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC194 Lentivirus Second scFv-CD28-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC195 Lentivirus Second scFv-41BB-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC196 Lentivirus First scFv-CD28-41BB-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC585 806 Lentivirus First scFv (806)-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC586 806 Lentivirus Second scFv (806)-CD28-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC587 806 Lentivirus Second scFv (806)-41BB-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC588 806 Lentivirus Third scFv (806)-CD28-41BB-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC676 Cetuximab Lentivirus Second scFv (Cetuximab)-CD28-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC738 Cetuximab Lentivirus Second scFv (Cetuximab)-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC739 Cetuximab Lentivirus Second scFv (Cetuximab)-41BB-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC740 Cetuximab Lentivirus Third scFv (Cetuximab)-CD28-41BB-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC741 Nimotuzumab Lentivirus First scFv (Nimotuzumab)-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC742 Nimotuzumab Lentivirus Second scFv (Nimotuzumab)-CD28-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC743 Nimotuzumab Lentivirus Second scFv (Nimotuzumab)-41BB-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC744 Nimotuzumab Lentivirus Third scFv (Nimotuzumab)-CD28-41BB-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC857 R1 Lentivirus First scFv (R1)-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC858 R1 Lentivirus Second scFv (R1)-41BB-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC859 R1 Lentivirus Second scFv (R1)-CD28-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
CONTACT US

USA
45-1 Ramsey Road, Shirley, NY 11967, USA
Tel: 1-631-871-5806
Fax: 1-631-207-8356
Email:

Europe
Ringstrasse 4, 64401 Gross-Bieberau, Germany
Tel: 44-207-097-1828

Distributors

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Australia
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