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EGFR

The epidermal growth factor receptor (EGFR) belongs to the ErbB family of receptor tyrosine kinases (RTK). These trans-membrane proteins are activated following binding with peptide growth factors of the EGF-family of proteins. Evidence suggests that the EGFR is involved in the pathogenesis and progression of different carcinoma types. The EGFR and EGF-like peptides are often over-expressed in human carcinomas. Mutations that lead to EGFR overexpression (known as upregulation) or overactivity have been associated with a number of cancers, including squamous-cell carcinoma of the lung (80% of cases), anal cancers, glioblastoma (50%) and epithelian tumors of the head and neck (80-100%).

Associated Disease
  • CAR Vector Products
  • CAR Viral Particles
  • DMAb
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CAT Product Name Target SpeciesAntibody CloneAntibody HostReceptor ConstructionVector TypeTargeting Cell Type Inquiry & Datasheet
CAR-T-1-L338-2 Anti-EGFR scFv h(CD28) CART, pCDCAR1 Human Human scFv-CD28 Lentiviral T cell   Add to Cart   Datasheet
CAR-T-1-L338-G Anti-EGFR scFv h(FcεRIγ) CART, pCDCAR1 Human Human scFv-FcεRIγ Lentiviral T cell   Add to Cart   Datasheet
CAR-T-1-L338-Z Anti-EGFR scFv h(CD3ζ) CART, pCDCAR1 Human Human scFv-CD3ζ Lentiviral T cell   Add to Cart   Datasheet
CAR-T-2-L338-2G Anti-EGFR scFv h(CD28-FcεRIγ) CART, pCDCAR1 Human Human scFv-CD28-FcεRIγ Lentiviral T cell   Add to Cart   Datasheet
CAR-T-2-L338-2Z Anti-EGFR scFv h(CD28-CD3ζ) CART, pCDCAR1 Human Human scFv-CD28-CD3ζ Lentiviral T cell   Add to Cart   Datasheet
CAR-T-2-L338-4G Anti-EGFR scFv h(CD4-FcεRIγ) CART, pCDCAR1 Human Human scFv-CD4-FcεRIγ Lentiviral T cell   Add to Cart   Datasheet
CAR-T-2-L338-4Z Anti-EGFR scFv h(CD4-CD3ζ) CART, pCDCAR1 Human Human scFv-CD4-CD3ζ Lentiviral T cell   Add to Cart   Datasheet
CAR-T-2-L338-8Z Anti-EGFR scFv h(CD8-CD3ζ) CART, pCDCAR1 Human Human scFv-CD8-CD3ζ Lentiviral T cell   Add to Cart   Datasheet
CAR-T-2-L338-BZ Anti-EGFR scFv h(41BB-CD3ζ) CART, pCDCAR1 Human Human scFv-41BB-CD3ζ Lentiviral T cell   Add to Cart   Datasheet
CAR-T-2-L338-CZ Anti-EGFR scFv h(b2c-CD3ζ) CART, pCDCAR1 Human Human scFv-b2c-CD3ζ Lentiviral T cell   Add to Cart   Datasheet
CAR-T-3-L338-2BZ Anti-EGFR scFv h(CD28-41BB-CD3ζ) CART, pCDCAR1 Human Human scFv-CD28-41BB-CD3ζ Lentiviral T cell   Add to Cart   Datasheet
CAR-T-3-L338-2XZ Anti-EGFR scFv h(CD28-OX40-CD3ζ) CART, pCDCAR1 Human Human scFv-CD28-OX40-CD3ζ Lentiviral T cell   Add to Cart   Datasheet
CAR-LC097 Anti-EGFR (806) h(CD3ζ) CAR, pCDCAR1 Human 806 Human scFv-CD3ζ Lentiviral T cell   Add to Cart   Datasheet
CAR-LC098 Anti-EGFR (806) h(CD28-CD3ζ) CAR, pCDCAR1 Human 806 Human scFv-CD28-CD3ζ Lentiviral T cell   Add to Cart   Datasheet
CAR-LC099 Anti-EGFR (806) h(41BB-CD3ζ) CAR, pCDCAR1 Human 806 Human scFv-41BB-CD3ζ Lentiviral T cell   Add to Cart   Datasheet
CAR-LC100 Anti-EGFR (806) h(CD28-41BB-CD3ζ) CAR, pCDCAR1 Human 806 Human scFv-CD28-41BB-CD3ζ Lentiviral T cell   Add to Cart   Datasheet
CAR-LC198 Anti-EGFR (Cetuximab) h(CD28-CD3ζ) CAR, pCDCAR1 Human Cetuximab Mouse scFv-CD28-CD3ζ Lentiviral T cell   Add to Cart   Datasheet
CAR-LC127 Anti-EGFR (Cetuximab) h(41BB-CD3ζ) CAR, pCDCAR1 Human Cetuximab Human scFv-41BB-CD3ζ Lentiviral NK cell   Add to Cart   Datasheet
CAR-LC376 Anti-EGFR h(CD3ζ, GITR) Armoured CAR, pCDCAR1 Human Human scFv-CD3ζ-GITR Retroviral T cell   Add to Cart   Datasheet
CAR-LC377 Anti-EGFR h(CD28-CD3ζ, GITR) Armoured CAR, pCDCAR1 Human Human scFv-CD28-CD3ζ-GITR Retroviral T cell   Add to Cart   Datasheet
CAR-LC378 Anti-EGFR h(CD28-CD3ζ, GITR) Armoured CAR, pCDCAR1 Human Human scFv-GITR-CD28-CD3ζ Retroviral T cell   Add to Cart   Datasheet
CAR-MZ165 Anti-EGFR (R1) h(CD28-CD3ζ) CAR, Pcdcar1 Human R1 Mouse scFv-CD28-CD3ζ Lentiviral NK cell   Add to Cart   Datasheet
CAR-MZ005 Anti-EGFR (Cetuximab) h(CD3ζ) CAR, pCDCAR1 Human Cetuximab Human/mouse chimeric scFv-CD3ζ Lentiviral T cell   Add to Cart   Datasheet
CAR-MZ007 Anti-EGFR (Cetuximab) h(41BB-CD3ζ) CAR, pCDCAR1 Human Cetuximab Human/mouse chimeric scFv-41BB-CD3ζ Lentiviral T cell   Add to Cart   Datasheet
CAR-MZ008 Anti-EGFR (Cetuximab) h(CD28-41BB-CD3ζ) CAR, pCDCAR1 Human Cetuximab Human/mouse chimeric scFv-CD28-41BB-CD3ζ Lentiviral T cell   Add to Cart   Datasheet
CAR-MZ009 Anti-EGFR (Nimotuzumab) h(CD3ζ) CAR, pCDCAR1 Human Nimotuzumab Humanized scFv-CD3ζ Lentiviral T cell   Add to Cart   Datasheet
CAR-MZ010 Anti-EGFR (Nimotuzumab) h(CD28-CD3ζ) CAR, pCDCAR1 Human Nimotuzumab Humanized scFv-CD28-CD3ζ Lentiviral T cell   Add to Cart   Datasheet
CAR-MZ011 Anti-EGFR (Nimotuzumab) h(41BB-CD3ζ) CAR, pCDCAR1 Human Nimotuzumab Humanized scFv-41BB-CD3ζ Lentiviral T cell   Add to Cart   Datasheet
CAR-MZ012 Anti-EGFR (Nimotuzumab) h(CD28-41BB-CD3ζ) CAR, pCDCAR1 Human Nimotuzumab Humanized scFv-CD28-41BB-CD3ζ Lentiviral T cell   Add to Cart   Datasheet
CAR-MZ163 Anti-EGFR (R1) h(CD3ζ) CAR, Pcdcar1 Human R1 Mouse scFv-CD3ζ Lentiviral NK cell   Add to Cart   Datasheet
CAR-MZ164 Anti-EGFR (R1) h(41BB-CD3ζ) CAR, Pcdcar1 Human R1 Mouse scFv-41BB-CD3ζ Lentiviral NK cell   Add to Cart   Datasheet
CAR-ZP155 Anti-EGFR (425) h(41BB-CD3ζ) CAR, pCDCAR1 Human 425 Humanized scFv-4-1BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-YF125 Anti-EGFR (CBL-YF042) h(4-1BB-CD3ζ) CAR, pCDCAR1 Human CBL-YF042 Human scFv-4-1BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-YF126 Anti-EGFR (CBL-YF042) h(CD28-CD3ζ) CAR, pCDCAR1 Human CBL-YF042 Human scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP154 Anti-EGFR (425) h(CD28-CD3ζ) CAR, pCDCAR1 Human 425 Humanized scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP224 Anti-EGFR (DL06) h(CD28-CD3ζ) CAR, pCDCAR1 Human DL06 Humanized scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-CQ0771 Anti-EGFR (5BA23) h(41BB-CD3ζ) CAR, pCDCAR1 Human 5BA23 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-CQ4195 Anti-EGFR (5BA23) h(CD28-CD3ζ) CAR, pCDCAR1 Human 5BA23 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP8155 Anti-EGFR (H9B4) h(4-1BB-CD3ζ) CAR, pCDCAR1 Human H9B4 Mouse scFv-4-1BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP8157 Anti-EGFR (GT461) h(4-1BB-CD3ζ) CAR, pCDCAR1 Human GT461 Mouse scFv-4-1BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet

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