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The epidermal growth factor receptor (EGFR) belongs to the ErbB family of receptor tyrosine kinases (RTK). These trans-membrane proteins are activated following binding with peptide growth factors of the EGF-family of proteins. Evidence suggests that the EGFR is involved in the pathogenesis and progression of different carcinoma types. The EGFR and EGF-like peptides are often over-expressed in human carcinomas. Mutations that lead to EGFR overexpression (known as upregulation) or overactivity have been associated with a number of cancers, including squamous-cell carcinoma of the lung (80% of cases), anal cancers, glioblastoma (50%) and epithelian tumors of the head and neck (80-100%).
Associated Disease
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| CAT | Product Name | Target Species | Antibody Clone | Antibody Host | Receptor Construction | Vector Type | Targeting Cell Type | CAR Vector Type | Inquiry & Datasheet |
| CAR-WFY6597 | Anti-EGFR (CBFYE-0240) h(41BB-CD3ζ) CAR, pCDCAR1 | Human | CBFYE-0240 | Rat | scFv-41BB-CD3ζ | Lentiviral vector | T cell | ||
| CAR-WFY6598 | Anti-EGFR (CBFYE-0546) h(41BB-CD3ζ) CAR, pCDCAR1 | Human, Mouse, Rat | CBFYE-0546 | Mouse | scFv-41BB-CD3ζ | Lentiviral vector | T cell | ||
| CAR-WFY6599 | Anti-EGFR (CBFYE-0547) h(41BB-CD3ζ) CAR, pCDCAR1 | Human | CBFYE-0547 | Mouse | scFv-41BB-CD3ζ | Lentiviral vector | T cell | ||
| CAR-WFY6600 | Anti-EGFR (CBFYE-0548) h(41BB-CD3ζ) CAR, pCDCAR1 | Human | CBFYE-0548 | Mouse | scFv-41BB-CD3ζ | Lentiviral vector | T cell | ||
| CAR-ZP8476 | A uniCAR [Anti-FITC CAR], with a mAb-based CAR Adaptor [Anti-EGFR (Cetuximab)], a Switchable CAR System | Breast cancer | Lentiviral vector | ||||||
| CAR-ZP8493 | A uniCAR [Anti-CD16 CAR], with a mAb-based CAR Adaptor [Anti-EGFR (Cetuximab)], a Switchable CAR System | Breast cancer | Lentiviral vector | ||||||
| CAR-ZP8494 | A uniCAR [Anti-CD16 CAR], with a mAb-based CAR Adaptor [Anti-EGFR (Panitumumab)], a Switchable CAR System | Breast cancer | Lentiviral vector | ||||||
| CAR-MV-01LX039 | Anti-EGFR (EGFR-scFv) h(CD28-CD3ζ) CAR, pMMLV | Human | EGFR-scFv | Human | scFv-CD28-CD3ζ | Recombinant Moloney murine leukemia virus (MMLV) retroviral vector | T cell | ||
| CAR-MV-01LX284 | Anti-EGFR (EGFR-scFv) h(41BB-CD3ζ) CAR, pMMLV | Human | EGFR-scFv | Human | scFv-41BB-CD3ζ | Recombinant Moloney murine leukemia virus (MMLV) retroviral vector | T cell | ||
| CAR-SB-02LX037 | Anti-EGFR (EGFR-scFv) h(CD28-41BB-CD3ζ) CAR, pSBCAR1 | Human | EGFR-scFv | Human | scFv-CD28-41BB-CD3ζ | Sleeping Beauty (SB) transposon | T cell | ||
| CAR-SB-02LX279 | Anti-EGFR (EGFR-scFv) h(CD28-OX40-CD3ζ) CAR, pSBCAR1 | Human | EGFR-scFv | Human | scFv-CD28-OX40-CD3ζ | Sleeping Beauty (SB) transposon | T cell | ||
| CAR-SB-02LX521 | Anti-EGFR (EGFR-scFv) h(ICOS-4-1BB-CD3ζ) CAR, pSBCAR1 | Human | EGFR-scFv | Human | scFv-ICOS-4-1BB-CD3ζ | Sleeping Beauty (SB) transposon | T cell | ||
| XS-0622-ZP3204 | Anti-EGFR h(VHH1-VHH2-CD28-CD3ζ) Biepitopic CAR, pCDCAR1 | Human | VHH1-VHH2-CD28-CD3ζ | Lentiviral vector | T Cell | ||||
| XS-0622-ZP3376 | Anti-EGFR h(VHH1-VHH2-4-1BB-CD3ζ) Biepitopic CAR, pCDCAR1 | VHH1-VHH2-4-1BB-CD3ζ | Lentiviral vector | T Cell | |||||
| XS-0722-YF32 | TS-Fluc Anti-Human EGFR scFv (Cetuximab) CD28-CD3ζ CAR, pCDCAR1 | Human | Cetuximab | Human | 7H-YB-Fluc-EF1a-scFv-CD28-CD3ζ | Lentiviral vector | T cell | ||
| XS-0722-YF92 | TS-Fluc Anti-Human EGFR scFv (Cetuximab) 4-1BB-CD3ζ CAR, pCDCAR1 | Human | Cetuximab | Human | 7H-YB-Fluc-EF1a-scFv-41BB-CD3ζ | Lentiviral vector | T cell | ||
| XS-0722-YF152 | TS-Fluc Anti-Human EGFR scFv (Cetuximab) CD28-4-1BB-CD3ζ CAR, pCDCAR1 | Human | Cetuximab | Human | 7H-YB-Fluc-EF1a-scFv-CD28-41BB-CD3ζ | Lentiviral vector | T cell | ||
| XS-0722-YF212 | TS-IL15 SA Anti-Human EGFR scFv (Cetuximab) CD28-CD3ζ CAR, pCDCAR1 | Human | Cetuximab | Human | 7H-YB-IL15 SA-EF1a-scFv-CD28-CD3ζ | Lentiviral vector | T cell | ||
| XS-0722-YF272 | TS-IL15 SA Anti-Human EGFR scFv (Cetuximab) 4-1BB-CD3ζ CAR, pCDCAR1 | Human | Cetuximab | Human | 7H-YB-IL15 SA-EF1a-scFv-41BB-CD3ζ | Lentiviral vector | T cell | ||
| XS-0722-YF332 | TS-IL15 SA Anti-Human EGFR scFv (Cetuximab) CD28-4-1BB-CD3ζ CAR, pCDCAR1 | Human | Cetuximab | Human | 7H-YB-IL15 SA-EF1a-scFv-CD28-41BB-CD3ζ | Lentiviral vector | T cell | ||
| XS-0722-YF392 | TS-NKG2DL Anti-hCD3 and Anti-Human EGFR scFv (Cetuximab) CD28-CD3ζ CAR, pCDCAR1 | Human | Cetuximab | Human | 7H-YB-NKG2DL Anti-hCD3 and (OKT3 scFv-NKG2D ECD)-EF1a-scFv-CD28-CD3ζ | Lentiviral vector | T cell | ||
| XS-0722-YF452 | TS-NKG2DL Anti-hCD3 and Anti-Human EGFR scFv (Cetuximab) 4-1BB-CD3ζ CAR, pCDCAR1 | Human | Cetuximab | Human | 7H-YB-NKG2DL Anti-hCD3 and (OKT3 scFv-NKG2D ECD)-EF1a-scFv-41BB-CD3ζ | Lentiviral vector | T cell | ||
| XS-0722-YF512 | TS-NKG2DL Anti-hCD3 and Anti-Human EGFR scFv (Cetuximab) CD28-4-1BB-CD3ζ CAR, pCDCAR1 | Human | Cetuximab | Human | 7H-YB-NKG2DL Anti-hCD3 and (OKT3 scFv-NKG2D ECD)-EF1a-scFv-CD28-41BB-CD3ζ | Lentiviral vector | T cell |
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