EGFR

All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

The epidermal growth factor receptor (EGFR) belongs to the ErbB family of receptor tyrosine kinases (RTK). These trans-membrane proteins are activated following binding with peptide growth factors of the EGF-family of proteins. Evidence suggests that the EGFR is involved in the pathogenesis and progression of different carcinoma types. The EGFR and EGF-like peptides are often over-expressed in human carcinomas. Mutations that lead to EGFR overexpression (known as upregulation) or overactivity have been associated with a number of cancers, including squamous-cell carcinoma of the lung (80% of cases), anal cancers, glioblastoma (50%) and epithelian tumors of the head and neck (80-100%).

EGFR Associated Disease
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CAT Product Name Target Species Antibody Clone Antibody Host Receptor Construction Vector Type Targeting Cell Type CAR Vector Type Inquiry & Datasheet
CAR-T-1-L338-2 Anti-EGFR scFv h(CD28) CART, pCDCAR1 Human Human scFv-CD28 Lentiviral T cell   Add to Cart   Datasheet
CAR-T-1-L338-G Anti-EGFR scFv h(FcεRIγ) CART, pCDCAR1 Human Human scFv-FcεRIγ Lentiviral T cell   Add to Cart   Datasheet
CAR-T-1-L338-Z Anti-EGFR scFv h(CD3ζ) CART, pCDCAR1 Human Human scFv-CD3ζ Lentiviral T cell   Add to Cart   Datasheet
CAR-T-2-L338-2G Anti-EGFR scFv h(CD28-FcεRIγ) CART, pCDCAR1 Human Human scFv-CD28-FcεRIγ Lentiviral T cell   Add to Cart   Datasheet
CAR-T-2-L338-2Z Anti-EGFR scFv h(CD28-CD3ζ) CART, pCDCAR1 Human Human scFv-CD28-CD3ζ Lentiviral T cell   Add to Cart   Datasheet
CAR-T-2-L338-4G Anti-EGFR scFv h(CD4-FcεRIγ) CART, pCDCAR1 Human Human scFv-CD4-FcεRIγ Lentiviral T cell   Add to Cart   Datasheet
CAR-T-2-L338-4Z Anti-EGFR scFv h(CD4-CD3ζ) CART, pCDCAR1 Human Human scFv-CD4-CD3ζ Lentiviral T cell   Add to Cart   Datasheet
CAR-T-2-L338-8Z Anti-EGFR scFv h(CD8-CD3ζ) CART, pCDCAR1 Human Human scFv-CD8-CD3ζ Lentiviral T cell   Add to Cart   Datasheet
CAR-T-2-L338-BZ Anti-EGFR scFv h(41BB-CD3ζ) CART, pCDCAR1 Human Human scFv-41BB-CD3ζ Lentiviral T cell   Add to Cart   Datasheet
CAR-T-2-L338-CZ Anti-EGFR scFv h(b2c-CD3ζ) CART, pCDCAR1 Human Human scFv-b2c-CD3ζ Lentiviral T cell   Add to Cart   Datasheet
CAR-T-3-L338-2BZ Anti-EGFR scFv h(CD28-41BB-CD3ζ) CART, pCDCAR1 Human Human scFv-CD28-41BB-CD3ζ Lentiviral T cell   Add to Cart   Datasheet
CAR-T-3-L338-2XZ Anti-EGFR scFv h(CD28-OX40-CD3ζ) CART, pCDCAR1 Human Human scFv-CD28-OX40-CD3ζ Lentiviral T cell   Add to Cart   Datasheet
CAR-LC097 Anti-EGFR (806) h(CD3ζ) CAR, pCDCAR1 Human 806 Human scFv-CD3ζ Lentiviral T cell   Add to Cart   Datasheet
CAR-LC098 Anti-EGFR (806) h(CD28-CD3ζ) CAR, pCDCAR1 Human 806 Human scFv-CD28-CD3ζ Lentiviral T cell   Add to Cart   Datasheet
CAR-LC099 Anti-EGFR (806) h(41BB-CD3ζ) CAR, pCDCAR1 Human 806 Human scFv-41BB-CD3ζ Lentiviral T cell   Add to Cart   Datasheet
CAR-LC100 Anti-EGFR (806) h(CD28-41BB-CD3ζ) CAR, pCDCAR1 Human 806 Human scFv-CD28-41BB-CD3ζ Lentiviral T cell   Add to Cart   Datasheet
CAR-LC127 Anti-EGFR (Cetuximab) h(41BB-CD3ζ) CAR, pCDCAR1 Human Cetuximab Human scFv-41BB-CD3ζ Lentiviral NK cell   Add to Cart   Datasheet
CAR-LC198 Anti-EGFR (Cetuximab) h(CD28-CD3ζ) CAR, pCDCAR1 Human Cetuximab Mouse scFv-CD28-CD3ζ Lentiviral T cell   Add to Cart   Datasheet
CAR-LC376 Anti-EGFR h(CD3ζ, GITR) Armoured CAR, pCDCAR1 Human Human scFv-CD3ζ-GITR Retroviral T cell   Add to Cart   Datasheet
CAR-LC377 Anti-EGFR h(CD28-CD3ζ, GITR) Armoured CAR, pCDCAR1 Human Human scFv-CD28-CD3ζ-GITR Retroviral T cell   Add to Cart   Datasheet
CAR-ZP8476 A uniCAR [Anti-FITC CAR], with a mAb-based CAR Adaptor [Anti-EGFR (Cetuximab)], a Switchable CAR System Breast cancer Lentiviral vector   Add to Cart   Datasheet
CAR-ZP8493 A uniCAR [Anti-CD16 CAR], with a mAb-based CAR Adaptor [Anti-EGFR (Cetuximab)], a Switchable CAR System Breast cancer Lentiviral vector   Add to Cart   Datasheet
CAR-ZP8494 A uniCAR [Anti-CD16 CAR], with a mAb-based CAR Adaptor [Anti-EGFR (Panitumumab)], a Switchable CAR System Breast cancer Lentiviral vector   Add to Cart   Datasheet
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