GPC3

Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation. The protein encoded by this gene can bind to and inhibit the dipeptidyl peptidase activity of CD26, and it can induce apoptosis in certain cell types. Deletion mutations in this gene are associated with Simpson-Golabi-Behmel syndrome, also known as Simpson dysmorphia syndrome. Alternative splicing results in multiple transcript variants.

Associated Disease
  • Hepatocellular carcinoma

CAR Vector Products Product list:

Catalog Targeting
Cell Type
Generation Antibody
Clone
Vector
Length
Vector
Type
Vector Design Antibody
Host
Data
sheet
Price
CAR-YF066 T cell Second CBL-YF017 ~8kb Lentiviral vector scFv-4-1BB-CD3ζ Humanized Inquiry
CAR-YF067 T cell Second CBL-YF017 ~8kb Lentiviral vector scFv-CD28-CD3ζ Humanized Inquiry
CAR-YF161 T cell Second CBL-YF051 ~8kb Lentiviral vector scFv-4-1BB-CD3ζ Mouse Inquiry
CAR-YF162 T cell Second CBL-YF051 ~8kb Lentiviral vector scFv-CD28-CD3ζ Mouse Inquiry
CAR-ZP126 NK cell Second hu9F2 ~8kb Lentiviral vector scFv-CD28-CD3ζ Humanized Inquiry
CAR-ZP127 NK cell Second hu9F2 ~8kb Lentiviral vector scFv-4-1BB-CD3ζ Humanized Inquiry
CAR-ZP200 T cell Second 1G12 ~8kb Lentiviral vector scFv-CD28-CD3ζ Mouse Inquiry
CAR-ZP201 T cell Second 1G12 ~8kb Lentiviral vector scFv-4-1BB-CD3ζ Mouse Inquiry
CAR-ZP202 T cell Second GPC3A-37 ~8kb Lentiviral vector scFv-CD28-CD3ζ Mouse Inquiry
CAR-ZP203 T cell Second GPC3A-37 ~8kb Lentiviral vector scFv-4-1BB-CD3ζ Mouse Inquiry

TCR Vector Products Product list:

Catalog Target Target
Species
Antibody
Clone
scFv-Host
Animal
Vector
length
Vector
Type
Epitope Format HLA Data
sheet
Price
TCR-ZP051 GPC3 Human 1 Mouse ~8kb Lentiviral vector EYILSLEEL Non-Modified TCR HLA-A24 Inquiry
TCR-ZP052 GPC3 Human 2 Mouse ~8kb Lentiviral vector FVGEFFTDV Non-Modified TCR HLA-A02 Inquiry
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