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GPC3

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Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation. The protein encoded by this gene can bind to and inhibit the dipeptidyl peptidase activity of CD26, and it can induce apoptosis in certain cell types. Deletion mutations in this gene are associated with Simpson-Golabi-Behmel syndrome, also known as Simpson dysmorphia syndrome. Alternative splicing results in multiple transcript variants.

Associated Disease
  • Hepatocellular carcinoma

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  • Target Species:
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CAT Product Name Target Species Antibody Clone Antibody Host Receptor Construction Vector Type Targeting Cell Type CAR Vector Type Inquiry & Datasheet
XS-1122-YF5080 Anti-GPC3 TCR-ABR (scFv-CD3ε, XW-480) CAR Plasmid, pCDCAR1 Human XW-480 Mouse scFv-CD3ε Lentiviral vector T Cell   Add to Cart   Datasheet
XS-1122-YF6916 Anti-GPC3 (XW-476) h(41BB-CD3ζ) CAR, pAAV Human XW-476 Mouse scFv-41BB-CD3ζ Adeno-associated viral (AAV) vector T Cell   Add to Cart   Datasheet
XS-1122-YF6917 Anti-GPC3 (GC33) h(41BB-CD3ζ) CAR, pAAV Human GC33 Mouse scFv-41BB-CD3ζ Adeno-associated viral (AAV) vector T Cell   Add to Cart   Datasheet
XS-1122-YF6918 Anti-GPC3 (XW-478) h(41BB-CD3ζ) CAR, pAAV Human XW-478 Mouse scFv-41BB-CD3ζ Adeno-associated viral (AAV) vector T Cell   Add to Cart   Datasheet
XS-1122-YF6919 Anti-GPC3 (XW-479) h(41BB-CD3ζ) CAR, pAAV Human XW-479 Mouse scFv-41BB-CD3ζ Adeno-associated viral (AAV) vector T Cell   Add to Cart   Datasheet
XS-1122-YF6920 Anti-GPC3 (XW-480) h(41BB-CD3ζ) CAR, pAAV Human XW-480 Mouse scFv-41BB-CD3ζ Adeno-associated viral (AAV) vector T Cell   Add to Cart   Datasheet
XS-0123-ZP220 Anti-GPC3 (2G9) h(scFv-CD3ε) TRuC, pCDTRC1 Human 2G9 Human scFv-CD3ε Lentiviral vector T cell   Add to Cart   Datasheet
XS-0123-ZP221 Anti-GPC3 (XS-0123-ZP221) h(scFv-CD3ε) TRuC, pCDTRC1 Human XS-0123-ZP221 Human scFv-CD3ε Lentiviral vector T cell   Add to Cart   Datasheet
XS-0123-ZP222 Anti-GPC3 (3D8) h(scFv-CD3ε) TRuC, pCDTRC1 Human 3D8 Human scFv-CD3ε Lentiviral vector T cell   Add to Cart   Datasheet
XS-0123-ZP223 Anti-GPC3 (PA21) h(scFv-CD3ε) TRuC, pCDTRC1 Human PA21 Human scFv-CD3ε Lentiviral vector T cell   Add to Cart   Datasheet
XS-0123-ZP224 Anti-GPC3 (2E10) h(scFv-CD3ε) TRuC, pCDTRC1 Human 2E10 Human scFv-CD3ε Lentiviral vector T cell   Add to Cart   Datasheet
XS-0123-ZP225 Anti-GPC3 (V209(nGlm(1))) h(scFv-CD3ε) TRuC, pCDTRC1 Human V209(nGlm(1)) Human scFv-CD3ε Lentiviral vector T cell   Add to Cart   Datasheet
XS-0123-ZP226 Anti-GPC3 (V1608) h(scFv-CD3ε) TRuC, pCDTRC1 Human V1608 Human scFv-CD3ε Lentiviral vector T cell   Add to Cart   Datasheet
XS-0123-ZP227 Anti-GPC3 (Codrituzumab) h(scFv-CD3ε) TRuC, pCDTRC1 Human Codrituzumab Human scFv-CD3ε Lentiviral vector T cell   Add to Cart   Datasheet
XS-0123-ZP777 Anti-GPC3 (G2) h(scFv-CD3ε) TRuC, pCDTRC1 Human G2 Mouse scFv-CD3ε Lentiviral vector T cell   Add to Cart   Datasheet
XS-0123-ZP799 Anti-GPC3 (YP7) h(scFv-CD3ε) TRuC, pCDTRC1 Human YP7 Mouse scFv-CD3ε Lentiviral vector T cell   Add to Cart   Datasheet
XS-0123-ZP800 Anti-GPC3 (GC33) h(scFv-CD3ε) TRuC, pCDTRC1 Human GC33 Mouse scFv-CD3ε Lentiviral vector T cell   Add to Cart   Datasheet
XS-0123-ZP801 Anti-GPC3 (HN3) h(scFv-CD3ε) TRuC, pCDTRC1 Human HN3 Mouse scFv-CD3ε Lentiviral vector T cell   Add to Cart   Datasheet
XS-0123-ZP802 Anti-GPC3 (ERY974) h(scFv-CD3ε) TRuC, pCDTRC1 Human ERY974 Mouse scFv-CD3ε Lentiviral vector T cell   Add to Cart   Datasheet
XS-0123-ZP803 Anti-GPC3 (M/YC-28) h(scFv-CD3ε) TRuC, pCDTRC1 Human M/YC-28 Mouse scFv-CD3ε Lentiviral vector T cell   Add to Cart   Datasheet
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