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KPNB1

All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

Nucleocytoplasmic transport, a signal- and energy-dependent process, takes place through nuclear pore complexes embedded in the nuclear envelope. The import of proteins containing a nuclear localization signal (NLS) requires the NLS import receptor, a heterodimer of importin alpha and beta subunits also known as karyopherins. Importin alpha binds the NLS-containing cargo in the cytoplasm and importin beta docks the complex at the cytoplasmic side of the nuclear pore complex. In the presence of nucleoside triphosphates and the small GTP binding protein Ran, the complex moves into the nuclear pore complex and the importin subunits dissociate. Importin alpha enters the nucleoplasm with its passenger protein and importin beta remains at the pore. Interactions between importin beta and the FG repeats of nucleoporins are essential in translocation through the pore complex. The protein encoded by this gene is a member of the importin beta family. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2013]
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CAT Product Name Target Species Antibody Clone Antibody Host Receptor Construction Vector Type Targeting Cell Type CAR Vector Type Inquiry & Datasheet
CAR-WJ0859 Anti-KPNB1 (3E9) h(41BB-CD3ζ) CAR, pCDCAR1 Bovine 3E9 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-WJ0860 Anti-KPNB1 (1D7) h(41BB-CD3ζ) CAR, pCDCAR1 1D7 Rat scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-WJ0861 Anti-KPNB1 (CBWJN-0469) h(41BB-CD3ζ) CAR, pCDCAR1 Bovine CBWJN-0469 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-WJ3151 Anti-KPNB1 (3E9) h(CD28-CD3ζ) CAR, pCDCAR1 Bovine 3E9 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-WJ3152 Anti-KPNB1 (1D7) h(CD28-CD3ζ) CAR, pCDCAR1 1D7 Rat scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-WJ3153 Anti-KPNB1 (CBWJN-0469) h(CD28-CD3ζ) CAR, pCDCAR1 Bovine CBWJN-0469 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
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