SIGLEC8

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Sialic acidbinding immunoglobulin (Ig)like lectins, or SIGLECs (e.g., CD33 (MIM 159590)), are a family of type 1 transmembrane proteins each having a unique expression pattern, mostly in hemopoietic cells. SIGLEC8 is a member of the CD33like subgroup of SIGLECs, which are localized to 19q13.3q13.4 and have 2 conserved cytoplasmic tyrosinebased motifs: an immunoreceptor tyrosinebased inhibitory motif, or ITIM (see MIM 604964), and a motif homologous to one identified in signaling lymphocyte activation molecule (SLAM; MIM 603492) that mediates an association with SLAMassociated protein (SAP; MIM 300490) (summarized by Foussias et al., 2000 [PubMed 11095983]).
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CAT Product Name Target Species Antibody Clone Antibody Host Receptor Construction Vector Type Targeting Cell Type CAR Vector Type Inquiry & Datasheet
XS-0822-YF2637 Anti-Human SIGLEC8 (XW-797) h(CD28-41BB-CD3ζ) CAR IVT Plasmid, pCARIVT Human XW-797 Mouse scFv-CD28-41BB-CD3ζ In Vitro Transcription (IVT) Vector   Add to Cart   Datasheet
XS-0822-YF2638 Anti-Human SIGLEC8 (XW-798) h(CD28-41BB-CD3ζ) CAR IVT Plasmid, pCARIVT Human XW-798 Mouse scFv-CD28-41BB-CD3ζ In Vitro Transcription (IVT) Vector   Add to Cart   Datasheet
XS-1122-YF1717 Anti-SIGLEC8 TCR-ABR (scFv-TCRα, XW-797) CAR Plasmid, pCDCAR1 Human XW-797 Mouse scFv-TCRα Lentiviral vector T Cell   Add to Cart   Datasheet
XS-1122-YF1718 Anti-SIGLEC8 TCR-ABR (scFv-TCRα, XW-798) CAR Plasmid, pCDCAR1 Human XW-798 Mouse scFv-TCRα Lentiviral vector T Cell   Add to Cart   Datasheet
XS-1122-YF1719 Anti-SIGLEC8 TCR-ABR (scFv-TCRα, XW-799) CAR Plasmid, pCDCAR1 Mouse XW-799 Rat scFv-TCRα Lentiviral vector T Cell   Add to Cart   Datasheet
XS-1122-YF3557 Anti-SIGLEC8 TCR-ABR (scFv-CD3γ, XW-797) CAR Plasmid, pCDCAR1 Human XW-797 Mouse scFv-CD3γ Lentiviral vector T Cell   Add to Cart   Datasheet
XS-1122-YF3558 Anti-SIGLEC8 TCR-ABR (scFv-CD3γ, XW-798) CAR Plasmid, pCDCAR1 Human XW-798 Mouse scFv-CD3γ Lentiviral vector T Cell   Add to Cart   Datasheet
XS-1122-YF3559 Anti-SIGLEC8 TCR-ABR (scFv-CD3γ, XW-799) CAR Plasmid, pCDCAR1 Mouse XW-799 Rat scFv-CD3γ Lentiviral vector T Cell   Add to Cart   Datasheet
XS-1122-YF4477 Anti-SIGLEC8 TCR-ABR (scFv-CD3δ, XW-797) CAR Plasmid, pCDCAR1 Human XW-797 Mouse scFv-CD3δ Lentiviral vector T Cell   Add to Cart   Datasheet
XS-1122-YF4478 Anti-SIGLEC8 TCR-ABR (scFv-CD3δ, XW-798) CAR Plasmid, pCDCAR1 Human XW-798 Mouse scFv-CD3δ Lentiviral vector T Cell   Add to Cart   Datasheet
XS-1122-YF4479 Anti-SIGLEC8 TCR-ABR (scFv-CD3δ, XW-799) CAR Plasmid, pCDCAR1 Mouse XW-799 Rat scFv-CD3δ Lentiviral vector T Cell   Add to Cart   Datasheet
XS-1122-YF8157 Anti-SIGLEC8 (XW-797) h(CD28-41BB-CD3ζ) CAR, pAAV Human XW-797 Mouse scFv-CD28-41BB-CD3ζ Adeno-associated viral (AAV) vector T Cell   Add to Cart   Datasheet
XS-1122-YF8158 Anti-SIGLEC8 (XW-798) h(CD28-41BB-CD3ζ) CAR, pAAV Human XW-798 Mouse scFv-CD28-41BB-CD3ζ Adeno-associated viral (AAV) vector T Cell   Add to Cart   Datasheet
XS-1122-YF8159 Anti-SIGLEC8 (XW-799) h(CD28-41BB-CD3ζ) CAR, pAAV Mouse XW-799 Rat scFv-CD28-41BB-CD3ζ Adeno-associated viral (AAV) vector T Cell   Add to Cart   Datasheet
XS-0123-ZP347 Anti-SIGLEC8 (2E2) h(scFv-CD3ε) TRuC, pCDTRC1 Human 2E2 Mouse scFv-CD3ε Lentiviral vector T cell   Add to Cart   Datasheet
XS-0123-ZP348 Anti-SIGLEC8 (EML1447) h(scFv-CD3ε) TRuC, pCDTRC1 Human EML1447 Mouse scFv-CD3ε Lentiviral vector T cell   Add to Cart   Datasheet
XS-0123-ZP569 Anti-SIGLEC8 (CB-P54) h(scFv-CD3ε) TRuC, pCDTRC1 Mouse CB-P54 Rat scFv-CD3ε Lentiviral vector T cell   Add to Cart   Datasheet
XS-0323-ZP347 Anti-SIGLEC8 (2E2 scFv-CD28TM-CD79β) CBCR(CAR-B), pCDCAR1 Human 2E2 Mouse scFv-CD28TM-CD79β Lentiviral vector T cell CAR-B Vector   Add to Cart   Datasheet
XS-0323-ZP348 Anti-SIGLEC8 (EML1447 scFv-CD28TM-CD79β) CBCR(CAR-B), pCDCAR1 Human EML1447 Mouse scFv-CD28TM-CD79β Lentiviral vector T cell CAR-B Vector   Add to Cart   Datasheet
XS-0323-ZP569 Anti-SIGLEC8 (CB-P54 scFv-CD28TM-CD79β) CBCR(CAR-B), pCDCAR1 Mouse CB-P54 Rat scFv-CD28TM-CD79β Lentiviral vector T cell CAR-B Vector   Add to Cart   Datasheet
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