Tat

Extracellular circulating Tat can be endocytosed by surrounding uninfected cells via the binding to several surface receptors such as CD26, CXCR4, heparan sulfate proteoglycans (HSPG) or LDLR. Neurons are rarely infected, but they internalize Tat via their LDLR. Through its interaction with nuclear HATs, Tat is potentially able to control the acetylation-dependent cellular gene expression. Modulates the expression of many cellular genes involved in cell survival, proliferation or in coding for cytokines or cytokine receptors. Tat plays a role in T-cell and neurons apoptosis. Tat induced neurotoxicity and apoptosis probably contribute to neuroAIDS.

Associated Disease
  • HIV-1 infection

TCR Vector Products Product list:

Catalog Target Target
Species
Antibody
Clone
scFv-Host
Animal
Vector
length
Vector
Type
Epitope Format HLA Data
sheet
Price
TCR-C243Z Tat HIV-1 c23  Human ~8kb Lentiviral ITKGLGISYGR Non-modified HLA-A68 Inquiry
TCR-L107Z Tat HIV Human 8kb Lentiviral ITKALGISYGR Non-modified HLA-A68 Inquiry
TCR-L108 Tat HIV Human 3111bp retroviral vector ITKGLGISYGR Non-modified TCR HLA-A68 Inquiry

TCR Viral Particles Product list:

Catalog Target
Species
Antibody
Clone
scFv-Host
Animal
Packaging
System
Epitope Format Titer Data
sheet
Price
VP-TCR-C504 HIV-1 c23  Human Lentivirus ITKGLGISYGR Non-modified TCR > 10⁷ IFU/ml Inquiry
VP-TCR-C505 HIV Human Lentivirus ITKGLGISYGR Non-modified TCR > 10⁷ IFU/ml Inquiry
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Tel: 44-207-048-3343

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