Extracellular circulating Tat can be endocytosed by surrounding uninfected cells via the binding to several surface receptors such as CD26, CXCR4, heparan sulfate proteoglycans (HSPG) or LDLR. Neurons are rarely infected, but they internalize Tat via their LDLR. Through its interaction with nuclear HATs, Tat is potentially able to control the acetylation-dependent cellular gene expression. Modulates the expression of many cellular genes involved in cell survival, proliferation or in coding for cytokines or cytokine receptors. Tat plays a role in T-cell and neurons apoptosis. Tat induced neurotoxicity and apoptosis probably contribute to neuroAIDS.

Associated Disease
  • HIV-1 infection
  • TCR Vector Products
  • TCR Viral Particles
  • Target Species:
  • Epitope:
  • Vector Type:
CAT Product Name Target SpeciesAntibody CloneAntibody HostEpitopeHLAVector Type Inquiry & Datasheet
TCR-L108 Human anti-tat (ITKGLGISYGR) T Cell Receptor, pGMT7 HIV Human ITKGLGISYGR HLA-A68 retroviral vector   Inquiry
TCR-C243Z Human anti-Tat T cell receptor (c23), pCDTCR1 HIV-1 c23  Human ITKGLGISYGR HLA-A68 Lentiviral   Inquiry
TCR-L107Z Human anti-Tat (aa39-49) T cell receptor, pCDTCR1 HIV Human ITKALGISYGR HLA-A68 Lentiviral   Inquiry

Key Updates

Receive the latest news and insights to your inbox.