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anti-Tat (aa39-49) TCR, pCDTCR1 (TCR-L107Z)

The vector of anti-Tat T cell receptor (TCR) is constructed for the engineering of T cell to target HIV Tat. The T cells are genetically modified through transduction with a retroviral vector expressing Tat-specific T cell receptor. And the vector product was designed for the treatment of AIDS.

Details

  • Target
  • Tat
  • Target Species
  • HIV
  • Epitope
  • ITKALGISYGR
  • Format
  • Non-modified
  • HLA
  • HLA-A68
  • Targeting Diseases
  • AIDS
  • Vector Name
  • pCDTCR1
  • Vector Length
  • 8kb
  • Vector Type
  • Lentiviral
  • Antibody Host
  • Human

Target

  • Gene Name
  • p14
  • Official Symbol
  • tat
  • Synonyms
  • HTLV1 p40; HTLV1 Tax; p40 antibody; tax antibody; TCR; T cell receptor; transgenic TCR; antigen-specific T cell receptors; Engineering T-cell receptors; recombinant t cell receptors; specific t cell receptor; modified t cell receptor; retroviral vector; Adult T cell leukaemia; ATL
  • Introduction
  • HIV1 tat (Transactivator of Transcription) protein is a pleiotropic factor that induces a broad range of biological effects in numerous cell types. At the HIV promoter, tat is a powerful transactivator of gene expression which acts by inducing chromatin remodeling and by recruiting elongation-competent transcriptional complexes on to the viral LTR.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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