Yeast Display based Antibody Discovery Services

SdAb BsAb Anti-Idiotype Anti-Membrane Protein CAR ADC Workflow Features

Utilizing high-throughput screening with the yeast display platform, Creative Biolabs offers rapid discovery of high-affinity antibodies that precisely target difficult proteins such as those embedded in membranes. We provide customized antibody discovery and enhancement solutions, including conventional scFv/Fab antibodies, single-domain antibodies (sdAbs), bispecific constructs, and anti-idiotype formats, together with engineered molecules for CAR-T cell therapy and antibody-drug conjugates (ADCs).

SdAb Discovery and Evaluation

Inquire to Us

Leveraging yeast display, a platform that affords both precision and high-throughput capacity, we enable the construction and rigorous screening of custom sdAb libraries and screening of sdAb candidates, prioritizing high affinity and target specificity - key determinants for successful downstream applications. Whether deployed in the refinement of diagnostic assays or the exploration of novel therapeutic avenues, our sdAb discovery service provides a strategic gateway.

Fig 1. A picture demonstrating sdAb. (Creative Biolabs Authorized).

BsAbs Discovery and Evaluation

Inquire to Us

Harnessing the power of yeast display, we offer bespoke bispecific antibody (BsAb) discovery and evaluation. This platform enables precise dual-targeting antibody identification, crucial for immune cell engagers and tumor therapies. From generation to binding analysis, we fine-tune affinities and specificities. Our services deliver high-quality BsAbs, accelerating research and therapeutic projects with enhanced efficacy.

Fig 2. A picture demonstrating antibody-1. (Creative Biolabs Authorized).

Anti-Idiotype Antibody Discovery and Evaluation

Inquire to Us

Yeast display enables rapid anti-idiotype antibody discovery, crucial for immune response tracking and therapeutic validation. We identify antibodies that precisely bind variable regions, facilitating targeted immunomodulation. High-affinity anti-idiotypes support diverse applications, from personalized treatments to monoclonal antibody validation. Our service addresses development challenges, ensuring accuracy and efficiency in your therapeutic research.

Fig 3. A picture demonstrating antibody-2. (Creative Biolabs Authorized).

Anti-Membrane Protein Antibody Discovery and Evaluation

Inquire to Us

The intricate and difficult-to-define structures of membrane proteins including GPCRs, ion channels, and transporters have historically posed significant obstacles for traditional antibody discovery techniques. Can yeast display technology provide the solution for antibody discovery challenges? By harnessing this advanced technology, the teams at Creative Biolabs are able to engineer custom antibodies that display both remarkable specificity and affinity, meticulously crafted to target these intricate membrane protein complexes.

Fig 4. A picture demonstrating membrane protein. (Creative Biolabs Authorized).

CAR Antibody Discovery

Inquire to Us

The yeast display-based CAR antibody discovery platform represents an efficient system that identifies high-affinity antibodies suitable for development into CAR constructs. Next-generation cancer immunotherapy development accelerates with this streamlined process which delivers essential antibody candidates for clinical translation through its inherent properties.

Fig 5. A picture demonstrating CAR-T. (Creative Biolabs Authorized).

ADC Discovery

Inquire to Us

Yeast display technology enables scientists to discover ADCs through the identification of antibodies that bind specific targets to ensure accurate delivery. Our service simplifies the identification of high-affinity antibodies which increases the effectiveness of ADCs development. Our specialized knowledge enables faster development of superior ADCs that improve therapeutic results.

Fig 6. A picture demonstrating ADC. (Creative Biolabs Authorized).

Workflow

Initial Consultation and Requirement Finalization

Define project goals, identify target antigens, and clarify application needs for sdAb, BsAb, anti-idiotype, anti-membrane protein, CAR, and ADC discovery.

Antigen & Source Material Preparation

Prepare antigen material (e.g., membrane proteins), and obtain or generate source materials (immunization samples or synthetic sequences) for the required antibody formats.

Custom Library Design and Construction

Design and construct high-diversity yeast display libraries tailored to project requirements.

High-Throughput Screening and Binder Validation

Screen libraries using yeast display, validating binders for stability, specificity, and functionality, with custom strategies for applications like anti-idiotype or anti-membrane protein antibody discovery.

Binding and Functional Characterization

Evaluate antibodies for binding affinity, stability, and function (e.g., neutralization, inhibition, activation) across antibodies.

Affinity Optimization

Enhance binding strength and specificity through affinity maturation to fine-tune performance.

Format Conversion and Engineering

We transform antibodies into various required formats like multi-domain antibodies and bispecific antibodies or BsAbs, ADCs, CARs, Fc fusions together with other specialized constructs.

Key Benefits of Our Yeast Display based Antibody Discovery

Unmatched Versatility

Our system is compatible with a broad spectrum of target types and complex screening scenarios.

Efficiency and Precision

High-throughput FACS-based screening enables the swift and precise selection of superior antibodies.

Tailored Results

Optimized approaches focus on selecting antibodies that fulfill your defined functional and structural needs.

Data-Driven Insights

Detailed reporting delivers essential insights for subsequent applications and advanced optimization.

Get In Touch

Our expert team stands ready to help you achieve your goals through personalized solution discussions. Our team stands ready to evaluate your unique project requirements alongside delivering full information to support cooperative work toward your research objectives.

All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.

	USA: Europe: Germany:
	Call us at: USA: UK: Germany:
	Fax:
	Email: