Cancer Glycomics Analysis

Creative Biolabs is a leading service provider that focuses on glycomics research. Based on our advanced platforms and extensive experience, now we can provide a series of cancer glycomics analysis services for our clients all over the world.

Introduction of Cancer and Glycomics

The research of the human genome, transcriptome, proteome, and epigenome has greatly promoted discoveries in biomedical science and the understanding of human disease processes. The developed technologies provide great opportunities and methods for cancer glycomics analysis. The term glycomics refers to the wide research of glycans or complex carbohydrates, in the form of oligosaccharide polymers, N- and O-linked glycoproteins, glycolipids, and proteoglycans. And glycosylation is the process that these sugars are added to protein or lipid carriers.

Studies have shown that changes in glycosylation are closely related to the development and progression of cancer, such as brain, breast, liver, lung, ovarian, pancreatic, prostate, etc.

Emerging Areas for Glycomics Research

• The altered mechanisms of regulation of the UDP-N-acetyl-D galactosamine.
• miRNA regulation of glycosyltransferase activity.
• Glycosylation in cancer exosomes/microvesicles.
• Glycan metabolism in the tumor environment and the hexosamine biosynthetic pathway have emerged as a key focal point in this process.

Fig.1 Important tumour-associated glycans. (Pinho, 2015)

Relation Between Glycosylation and Cancer

Glycosylation plays an important role in normal physiological functions in humans, including cell motility, cell-cell adhesion, inflammation, signal transduction, pathogen-host interactions, as well as viral entry. In this case, abnormal glycosylation in any of these processes may lead to tumors and cancers, and the altered glycan associated with a special cancer type would make this glycan a potential biomarker. By incorporating a tumor-specific glycoform, the specificity and sensitivity of glycoprotein cancer biomarkers can be improved.

Technologies for Cancer Glycomics Analysis

In order to better study cancer glycomics, the latest cutting-edge technologies have been developed to discover new cancer biomarkers and therapeutic targets, and different comprehensive cancer omics strategies have been proposed.

• High-resolution mass spectrometry that can be used to determine anomeric linkage and sugar composition.
• MALDI-TOF mass spectrometry is a common method for clinical sample analysis of glycans.

Creative Biolabs has been a long-term expert in the field of glycomics research. As a pioneer and the undisrupted global leader in cancer glycomics analysis, we offer a variety of solutions to improve your productivity and streamline your research processes. If you are interested in our products or services, please do not hesitate to contact us for more detailed information.

Reference

1. Pinho, S.S.&Reis, C.A. Glycosylation in cancer: mechanisms and clinical implications. Nature Reviews Cancer. 2015, 15(9):540-55.

Related Services:

1. Tumor-associated Glycan Detection
2. Cancer Specific Glycosyltransferase Gene Expression Profile
3. Technologies for Glyco-code Based Diagnostics