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With the latest technologies and advanced methods in the area of carbohydrate, Creative Biolabs is capable of offering high-quality acetylation modification services for global customers. Besides, we also provide acetylation modification analysis according to our customers' detailed requirements.
Acetylation is one of the major post-translational protein modifications in the cell, with manifold effects on the protein level as well as on the metabolome level. For example, acetylation of histones neutralizes the positive charge of lysine residues affecting the protein-protein interaction between histones and with the negatively charged DNA backbone, leading to more relaxed chromatin. Conversely, histone deacetylation allows a tighter interaction with DNA leading to more condensed chromatin that prevents access to the transcription machinery. The acetyl group, donated by the metabolite acetyl-coenzyme A, can be co- or post-translationally attached to either the α-amino group of the N-terminus of proteins or to the ε-amino group of lysine residues. These reactions are catalyzed by various N-terminal and lysine acetyltransferases. Lysine acetylation is a reversible post-translational modification (PTM) typically controlled by the following two groups of enzymes: lysine acetyltransferases (KATs), formerly called histone acetyltransferases (HATs) because they were first discovered for this group of proteins, and lysine deacetylases (KDACs), also referred to as histone deacetylases (HDACs) The interplay between acetylation and deacetylation is crucial for many important cellular processes.
Acetylation of polysaccharides makes more hydroxyl be exposed, thereby this can increase the solubility of polysaccharides in water, and is more conducive to the development of the biological activity. Acetylation commonly uses acetic acid and acetic anhydride as an acylating agent, the reaction is often carried out in organic solvents such as formamide. In recent years, it has shown that the acetylation of polysaccharides can improve the antioxidant, anti-tumor, immune regulation, and other biological activities. It was found that the anti-oxidative and immunomodulatory activities of black Ganoderma lucidum polysaccharide were enhanced after acetylation modification.
Fig.1 The acetylation of cellulose. (Chen, 2018)
Creative Biolabs has established a comprehensive and advanced technology platform to provide customers with various types of acetylation modification services. With the team of Ph.D. level experts devoted to acetylation modification for years, Creative Biolabs also provide acetylation modification analysis services. We have established a highly sensitive HPLC and MS platform that can analyze acetylation in multiple samples, and will also help with data interpretation.
Creative Biolabs is a forward-looking CRO company with extensive acetylation modification services experience. Our platform provides various advanced technologies and strategies, which make us capable of dealing with customers' any puzzle. Please feel free to contact us for more information.