Glycoproteomics-based Liquid-biopsy LDT Development Service for Advanced Adenoma

Importance of Glycosylation in Advanced Adenoma

Advanced adenoma, also known as advanced colorectal adenoma, is a type of precancerous growth or tumor that develops in the colon or rectum. Adenomas are benign tumors that have the potential to become cancerous over time. Detection and removal of advanced adenomas during colonoscopy are important for colorectal cancer prevention, as their removal can significantly reduce the risk of cancer development. Thus regular screening and surveillance are recommended. Glycosylation is a complex post-translational modification that plays a crucial role in various cellular processes, changes in glycosylation patterns can reflect underlying physiological or pathological conditions. Detecting and characterizing aberrant glycosylation in advanced adenoma can provide insights into the underlying molecular changes associated with disease progression. Liquid biopsy based on glycoproteomics is an innovative approach that leverages the specific glycosylation patterns of proteins associated with advanced adenomas, aiming to provide a non-invasive and sensitive method for early detection, risk assessment, and monitoring of these precancerous lesions.

Glycoproteomics-based Liquid-biopsy LDT Development for Advanced Adenoma at Creative Biolabs

Drawing upon profound proficiency in glycoproteomic analysis and advanced technological capabilities, Creative Biolabs has triumphantly formulated an all-encompassing liquid biopsy LDT platform for advanced adenoma. Our LDT development mainly involves but is not limited to:

• Advanced enrichment method and mass spectrometry analysis

For in-depth investigations into glycopeptide structures, our laboratory prioritizes the utilization of Hydrophilic Interaction Liquid Chromatography (HILIC), which demonstrates an unbiased affinity for diverse glycopeptide types, all while meticulously preserving the intricate architecture of sugar chains.

We offer state-of-the-art nano-liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS), adeptly employed through a data-independent acquisition (DIA) approach with improved accuracy and reproducibility.

• Comprehensive data interpretation and bioinformatics analysis

We utilize powerful in-house developed software to identify glycopeptides, glycan compositions, and glycosylation site assignments. Relative glycopeptide abundances are quantified through peak intensities or spectral counting.

Followed by rigorous statistical analysis and comprehensive bioinformatic exploration.

Fig.1 Data analysis in LDT development.

Advantages

Our glycoproteomics-based liquid biopsy service for advanced adenoma at Creative Biolabs offers a holistic approach to unraveling the intricate glycosylation patterns associated with the disease. If you are interested in our LDT services, please feel free to contact us for more detailed information.

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