Glycobiology Microarray
In the research of protein engineering, post-translational modification plays an important role in protein function, among which glycosylation is usually necessary for the biological activity of proteins. Therefore, the clear definiteness and detection of the carbohydrate-protein interactions lay a foundation to understand the action mode of functional proteins. Glycobiology microarray provides a powerful, high throughput approach to examining carbohydrate-protein interactions, and has a significant impact on the field of glycobiology. Creative Biolabs is a leading service provider that focuses on all kinds of protein studies. With years of experience in this area, we can provide a series of inexpensive and rapid glycobiology microarray services to match your protein glycosylation research.
Fig.1 Glycans-macromolecule interaction. (Oyelaran, 2009)
Introduction of Glycobiology Microarray
Detailed analyses of carbohydrate-protein interactions present difficulties at all levels because of limited amounts, structural diversity, synthesis difficulty and low affinity. However, several aspects of these challenges are now being addressed with the advent of glycobiology microarrays. Glycobiology microarrays, also referred to as carbohydrate microarrays or glycan microarrays, are composed of various oligosaccharides or polysaccharides immobilized on a solid support in a spatially defined arrangement. The main advantage of microarray analysis is that a broad range of glycans can be immobilized on solid matrices as minute spots and simultaneously interrogated. The multivalent display of arrayed saccharides can serve to mimic cell surface display and is ideal for detecting the generally very low affinities of interactions that involve carbohydrates. The miniaturization in microarrays is advantageous for making the most out of precious materials of both carbohydrates and protein analytes; and this, as well as the high-throughput feature of microarray technologies, is particularly well suited for investigations in glycomics, in which thousands of binding events can be assessed in parallel on a single chip containing tiny amounts of natural glycans.
What Can We Do?
The function of glycobiology microarray depends on the types of carbohydrate fixed on the chip, hence we provide various kinds of glycobiology microarray chips to match different requirements in glycoprotein research. Moreover, based on this established glycobiology microarray platform, we are able to offer many convenient glycoprotein-related services like Custom Synthesis, Glycoengineering Service, Glycoprotein Analysis, Anti-Glycoprotein Antibody Development, and Tumor Glyco-diag service.
Through protracted and unremitting efforts, we have created a comprehensive glycobiology microarray platform consistent about 10 kinds of commercial glycans microassay as described below chips.
It is no doubt that glycobiology microarray approach has been advanced as a useful tool in the emerging field of glycomics. If you are interest in our glycobiology microarray technology or have any related requirement, please feel free to contact us.
References
-
Oyelaran, O.; et al. Glycan arrays: recent advances and future challenges. Current opinion in chemical biology. 2009, 13(4), 406-413.
-
Dan, X.; et al. Development and applications of lectins as biological tools in biomedical research. Medicinal research reviews. 2016, 36(2), 221-247.
For Research Use Only.
Related Services:
- Lectin Microarray
- MS
- LC-ESI-MS
- MALDI-TOF MS
- HPLC
- HPAEC-PAD
- RP-HPLC
- UHPLC/FLD/Q-TOF
- FTIR
- NMR
- SPRi
- TLC
- Flow Cytometry
- GC-MS
- Imaging Mass Spectrometry
