Polysaccharides have exhibited good anticancer activity across a variety of cancer cell lines and can be developed as alternatives to existing cancer chemotherapeutic agents, owning selective activity against tumor cells with minimal toxic side-effects. Experienced in glycoscience and with a dedicated commitment to the scientific community, Creative Biolabs has perfected our technical pipelines in the identification and characterization of polysaccharides with anticancer activity. We would like to share our knowledge and passion in this field to facilitate our customers’ research and project development.
Cancer is a major public health problem worldwide and is the second leading cause of death in the world. The application of chemotherapeutic drugs available for the therapeutic management of cancer had some limitations in clinical settings, such as adverse effects, hemopoietic suppression, limited efficacy, immunotoxicity, and drug resistance. Therefore, many scientists have been devoted to developing alternative strategies or novel potent, but low toxic anti-cancer reagents, including natural products, and high efficacy to treat cancers. Anticancer efficacy of polysaccharides was first observed in 1946 when certain polysaccharides could induce complete remission in patients with cancer. Then, polysaccharides that act as adjuvant medicines are more commonly used in combination with chemotherapy/radiotherapy to treat various cancers.
Fig.1 Anticancer activity of polysaccharides via immunomodulation. (Khan, 2019)
Numerous researches have suggested that polysaccharides can inhibit tumor growth through the following mechanisms: 1) prevention of the tumorigenesis by oral administration of polysaccharides, 2) direct anti-cancer activity, such as the induction of tumor cell apoptosis, cell cycle arrest, and anti-angiogenesis. 3) inhibiting tumor invasion, adhesion, and metastasis. Polysaccharides can enhance host immune function, which has been considered the main or singular mechanism of some types of polysaccharides, especially β-glucans from fungi. Recently, the underlying anti-tumor mechanism of polysaccharides has been revealed that lentinan activates immune responses to induce tumor cell apoptosis through the caspase 3-dependent signaling pathway and inhibit tumor cell proliferation as well as anti-angiogenesis.
Creative Biolabs is dedicated to exploiting the vast potential of polysaccharides in drug development involves overcoming fundamental challenges to clarify the important structure-activity relationship and the anticancer mechanisms to help scientists to design high potential anticancer drugs. We are pleased to share our cutting-edge technology and extensive expertise in the identification of polysaccharides with anticancer activity to facilitate our clients’ research and project development. We also focus on the accurate measurement of structure parameters including composition, branches, sequence, linkage, and conformation of polysaccharides through a range of technologies.
Taking into consideration of the rising trend of cancers as well as the high anti-tumor efficacy and safety, developing polysaccharides as the effective therapies to control human malignancies is a potential strategy. Powered by our experienced technical personnel, Creative Biolabs is fully competent and dedicated to serving as your one-stop-shop for the identification of polysaccharides with anticancer activity and characterization of the target polysaccharides. For more detailed information, please feel free to contact us or directly send us an inquiry.