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Anti-α/β-gliadin MM1 T cell receptor (B452), pCDTCR1 (TCR-YC1386)

The vector of anti-α/β-gliadin MM1 T cell receptor (TCR) is constructed for the engineering of T cell to target Alpha/beta-gliadin MM1 precursor (SGQGSFQPSQQNP + DEAM(Q3, Q11)) restricted by HLA-DQA1*05:01/DQB1*03:02. The T cells are genetically modified through transduction with a lentiviral vector expressing α/β-gliadin MM1-specific T cell receptor.

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Details

  • Target
  • α/β-gliadin MM1
  • Target Species
  • Triticum aestivum
  • Epitope
  • SGQGSFQPSQQNP + DEAM(Q3, Q11)
  • Format
  • Non-Modified TCR
  • HLA
  • HLA-DQA1*05:01/DQB1*03:02
  • Targeting Diseases
  • HLA-DQ8–associated celiac disease (CD)
  • Vector Name
  • pCDTCR1
  • Vector Length
  • ~ 8 kb
  • Vector Type
  • Lentiviral vector
  • TCR Clone
  • B452
  • Host Species
  • Human

Target

  • Introduction
  • Gliadin (a type of prolamin) is a class of proteins present in wheat and several other cereals within the grass genus Triticum. Gliadins, which are a component of gluten, are essential for giving bread the ability to rise properly during baking. Gliadins and glutenins are the two main components of the gluten fraction of the wheat seed. This gluten is found in products such as wheat flour. Gluten is split about evenly between the gliadins and glutenins, although there are variations found in different sources. Gliadin is the water-insoluble component of gluten, and glutenin is water-soluble. There are three main types of gliadin (α, γ, and ω), to which the body is intolerant in coeliac (or celiac) disease. Diagnosis of this disease has recently been improving.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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