Anti-MAGE-A3 T cell receptor (R12C9), pCDTCR1(TCR-L363)

The vector of anti-MAGE-A3 T cell receptor (TCR) is constructed for the engineering of T cell to target Human MAGE-A3. The T cells are genetically modified through transduction with a lentiviral vector expressing MAGE-A3-specific T cell receptor. And the vector product was designed for the treatment of Melanmoma.


Details


Target
MAGE-A3
Target Species
Human
Epitope
AA243-258
Format
Murinized
HLA
HLA-DP*0401
Targeting Diseases
Melanmoma
Vector Name
pCDTCR1
Vector Length
~8kb
Vector Type
Lentiviral
Antibody Clone
R12C9
Antibody Host
Murinized

Target


Gene Name
MAGE family member A3
Official Symbol
MAGEA3
Gene ID
UniProt ID
Synonyms
CT1.4; MAGE4; MAGE4A; MAGE4B; MAGE-41; MAGE-X2; TCR; T cell receptor; transgenic TCR; antigen-specific T cell receptors; Engineering T-cell receptors; recombinant t cell receptors; specific t cell receptor; modified t cell receptor; retroviral vector; Esophageal cancer; head and neck cancer; non-small cell pulmonary cancer; stomach cancer; Hodgkin's disease
Introduction
This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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Tel: 1-631-871-5806
Fax: 1-631-207-8356
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