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pCDCAR1 CD123 h(γ), T (CAR-T-1-M306-G)

The vector of anti-CD123 chimeric antigen receptor (CAR) is constructed for the engineering of T cells to target human CD123. The T cells are genetically modified through transduction with a lentiviral vector expressing scFv of anti-CD123 antibody linked to FcεRIγ signaling domains. And the vector product was designed for the treatment of acute myeloid leukaemia (AML).

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Details

  • Target
  • CD123
  • Targeting Cell Type
  • T cell
  • Targeting Diseases
  • Acute myeloid leukaemia (AML)
  • Generation
  • First
  • Vector Name
  • pCDCAR1
  • Vector Length
  • 8kb
  • Vector Type
  • Lentiviral
  • Receptor Construction
  • scFv-FcεRIγ
  • Discription of Signaling Cassetes
  • FcεRIγ
    The high-affinity IgE receptor, also known as FcεRI, or Fc epsilon RI, is the high-affinity receptor for the Fc region of immunoglobulin E (IgE). FcεRI is a key molecule involved in allergic reactions. It is a tetramer composed of 1alpha, 1 beta, and 2 gamma chains. The gamma chains are also subunits of other Fc receptors. The scFv-based CARs engineered to contain a signaling domain from FcεRIγ have been shown to deliver a potent signal for T cell activation and function.

Target

  • Clone
  • 7G3
  • Host
  • Mouse
  • Target Species
  • Human
  • Gene Name
  • Interleukin 3 Receptor Subunit Alpha
  • Synonyms
  • Interleukin 3 Receptor Subunit Alpha

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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