ErbB2

ErbB-2, also known as human epidermal growth factor receptor 2 (HER2), cluster of differentiation 340 (CD340), proto-oncogene Neu, is encoded by the ERBB2 gene. As a member of the human epidermal growth factor receptor (HER/EGFR/ERBB) family, ErbB2 has become an important biomarker and target of therapy for breast cancer. Not only the overexpression of ErbB2 occurs in breast cancer, but also it is strongly associated with the ovarian cancer, stomach cancer, lung adenocarcinoma, uterine cancer, salivary gland cancer, acute lymphoblastic leukemia (ALL), bladder cancer, childhood medulloblastoma, colorectal cancer, oral squamous cell carcinoma, germ-cell testicular tumor, cholangiocarcinoma, osteosarcoma, pancreatic adenocarcinoma and prostate cancer.

Associated Disease

CAR Vector Products Product list:

Catalog Targeting
Cell Type
Generation Antibody
Clone
Vector
Length
Vector
Type
Vector Design Antibody
Host
Data
sheet
Price
CAR-MZ019 T cell Second Trastuzumab ~8kb Lentiviral scFv-CD28-CD3ζ Humanized Inquiry
CAR-MZ029 T cell Second C6-B1D2 ~8kb Lentiviral scFv-CD28-CD3ζ Human Inquiry
CAR-MZ030 T cell Second C6MH3-B1 ~8kb Lentiviral scFv-CD28-CD3ζ Human Inquiry
CAR-MZ031 T cell Second C6ML3-9 ~8kb Lentiviral scFv-CD28-CD3ζ Human Inquiry
CAR-MZ032 T cell Second C6.5 ~8kb Lentiviral scFv-CD28-CD3ζ Human Inquiry
CAR-MZ033 T cell Second C6.5G98A ~8kb Lentiviral scFv-CD28-CD3ζ Human Inquiry
CAR-MZ132 T cell Second L96 ~8kb Retroviral scFv-CD28-CD3ζ Mouse Inquiry
CAR-MZ133 T cell Second N29 ~8kb Retroviral scFv-CD28-CD3ζ Mouse Inquiry
CAR-MZ134 T cell Second 4D5 ~8kb Retroviral scFv-CD28-CD3ζ Mouse Inquiry
CAR-MZ135 T cell Second L96 ~8kb Retroviral scFv-CD28-FcγR Mouse Inquiry
CAR-MZ136 T cell Second N29 ~8kb Retroviral scFv-CD28-FcγR Mouse Inquiry
CAR-MZ137 T cell Second 4D5 ~8kb Retroviral scFv-CD28-FcγR Mouse Inquiry
CAR-NK-1-M331-2 NK cell First FRP5 8kb Lentiviral scFv-CD28 Rabbit Inquiry
CAR-NK-1-M331-G NK cell First FRP5 8kb Lentiviral scFv-FcεRIγ Rabbit Inquiry
CAR-NK-1-M331-Z NK cell First FRP5 8kb Lentiviral scFv-CD3ζ Rabbit Inquiry
CAR-NK-2-M331-2Z NK cell Second FRP5 8kb Lentiviral scFv-CD28-CD3ζ Rabbit Inquiry
CAR-NK-2-M331-4G NK cell Second FRP5 8kb Lentiviral scFv-CD4-FcεRIγ Rabbit Inquiry
CAR-NK-2-M331-4Z NK cell Second FRP5 8kb Lentiviral scFv-CD4-CD3ζ Rabbit Inquiry
CAR-NK-2-M331-8Z NK cell Second FRP5 8kb Lentiviral scFv-CD8-CD3ζ Rabbit Inquiry
CAR-NK-2-M331-BG NK cell Second FRP5 8kb Lentiviral scFv-CD28-FcεRIγ Rabbit Inquiry
CAR-NK-2-M331-BZ NK cell Second FRP5 8kb Lentiviral scFv-41BB-CD3ζ Rabbit Inquiry
CAR-NK-2-M331-CZ NK cell Second FRP5 8kb Lentiviral scFv-b2c-CD3ζ Rabbit Inquiry
CAR-NK-3-M331-2BZ NK cell Third FRP5 8kb Lentiviral scFv-CD28-41BB-CD3ζ Rabbit Inquiry
CAR-NK-3-M331-2XZ NK cell Third FRP5 8kb Lentiviral scFv-CD28-OX40-CD3ζ Rabbit Inquiry
CAR-T-1-L337-2 T cell First OTI5C4 8kb Lentiviral scFv-CD28 Mouse Inquiry
CAR-T-1-L337-G T cell First OTI5C4 8kb Lentiviral scFv-FcεRIγ Mouse Inquiry
CAR-T-1-L337-Z T cell First OTI5C4 8kb Lentiviral scFv-CD3ζ Mouse Inquiry
CAR-T-1-M550-2 T cell First 8kb Lentiviral VHH-CD28 Camelid Inquiry
CAR-T-1-M550-G T cell First 8kb Lentiviral VHH-FcεRIγ Camelid Inquiry
CAR-T-1-M550-Z T cell First 8kb Lentiviral VHH-CD3ζ Camelid Inquiry
CAR-T-2-L337-2G T cell Second OTI5C4 8kb Lentiviral scFv-CD28-FcεRIγ Mouse Inquiry
CAR-T-2-L337-2Z T cell Second OTI5C4 8kb Lentiviral scFv-CD28-CD3ζ Mouse Inquiry
CAR-T-2-L337-4G T cell Second OTI5C4 8kb Lentiviral scFv-CD4-FcεRIγ Mouse Inquiry
CAR-T-2-L337-4Z T cell Second OTI5C4 8kb Lentiviral scFv-CD4-CD3ζ Mouse Inquiry
CAR-T-2-L337-8Z T cell Second OTI5C4 8kb Lentiviral scFv-CD8-CD3ζ Mouse Inquiry
CAR-T-2-L337-BZ T cell Second OTI5C4 8kb Lentiviral scFv-41BB-CD3ζ Mouse Inquiry
CAR-T-2-L337-CZ T cell Second OTI5C4 8kb Lentiviral scFv-b2c-CD3ζ Mouse Inquiry
CAR-T-2-M550-2G T cell Second 8kb Lentiviral VHH-CD28-FcεRIγ Camelid Inquiry
CAR-T-2-M550-2Z T cell Second 8kb Lentiviral VHH-CD28-CD3ζ Camelid Inquiry
CAR-T-2-M550-4G T cell Second 8kb Lentiviral VHH-CD4-FcεRIγ Camelid Inquiry
CAR-T-2-M550-4Z T cell Second 8kb Lentiviral VHH-CD4-CD3ζ Camelid Inquiry
CAR-T-2-M550-8Z T cell Second 8kb Lentiviral VHH-CD8-CD3ζ Camelid Inquiry
CAR-T-2-M550-BZ T cell Second 8kb Lentiviral VHH-41BB-CD3ζ Camelid Inquiry
CAR-T-2-M550-CZ T cell Second 8kb Lentiviral VHH-b2c-CD3ζ Camelid Inquiry
CAR-T-3-L337-2BZ T cell Third OTI5C4 8kb Lentiviral scFv-CD28-41BB-CD3ζ Mouse Inquiry
CAR-T-3-L337-2XZ T cell Third OTI5C4 8kb Lentiviral scFv-CD28-OX40-CD3ζ Mouse Inquiry
CAR-T-3-M550-2BZ T cell Third 8kb Lentiviral VHH-CD28-41BB-CD3ζ Camelid Inquiry
CAR-T-3-M550-2XZ T cell Third 8kb Lentiviral VHH-CD28-OX40-CD3ζ Camelid Inquiry

CAR Viral Particles Product list:

Catalog Antibody
Clone
Packaging
System
Generation Gene
Construct
Promotor Packaging
Cell
Titer Data
sheet
Price
VP-CAR-LC221 OTI5C4 Lentivirus First scFv (OTI5C4)-CD28 CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC222 OTI5C4 Lentivirus First scFv (OTI5C4)-FcεRIγ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC223 OTI5C4 Lentivirus First scFv (OTI5C4)-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC224 OTI5C4 Lentivirus Second scFv (OTI5C4)-CD28-FcεRIγ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC225 OTI5C4 Lentivirus Second scFv (OTI5C4)-CD28-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC226 OTI5C4 Lentivirus Second scFv (OTI5C4)-CD4-FcεRIγ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC227 OTI5C4 Lentivirus Second scFv (OTI5C4)-CD4-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC228 OTI5C4 Lentivirus Second scFv (OTI5C4)-CD8-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC229 OTI5C4 Lentivirus Second scFv (OTI5C4)-41BB-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC230 OTI5C4 Lentivirus Second scFv (OTI5C4)-b2c-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC231 OTI5C4 Lentivirus Third scFv (OTI5C4)-CD28-41BB-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC232 OTI5C4 Lentivirus Third scFv (OTI5C4)-CD28-OX40-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC748 Trastuzumab Lentivirus Second scFv (Trastuzumab)-CD28-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC753 C6-B1D2 Lentivirus Second scFv (C6-B1D2)-CD28-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC754 C6MH3-B1 Lentivirus Second scFv (C6MH3-B1)-CD28-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC755 C6ML3-9 Lentivirus Second scFv (C6ML3-9)-CD28-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC756 C6.5 Lentivirus Second scFv (C6.5)-CD28-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC757 C6.5G98A Lentivirus Second scFv (C6.5G98A)-CD28-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC829 L96 Lentivirus Second scFv (L96)-CD28-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC830 N29 Lentivirus Second scFv (N29)-CD28-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC831 4D5 Lentivirus Second scFv (4D5)-CD28-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC832 L96 Lentivirus Second scFv (L96)-CD28-FcγR CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC833 N29 Lentivirus Second scFv (N29)-CD28-FcγR CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC834 4D5 Lentivirus Second scFv (4D5)-CD28-FcγR CMV 293T > 10⁷ IFU/ml Inquiry
CONTACT US

USA
45-1 Ramsey Road, Shirley, NY 11967, USA
Tel: 1-631-871-5806
Fax: 1-631-207-8356
Email:

Europe
Ringstrasse 4, 64401 Gross-Bieberau, Germany
Tel: 44-207-048-3343

Distributors

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