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WT1

This gene encodes a transcription factor that contains four zinc-finger motifs at the C-terminus and a proline/glutamine-rich DNA-binding domain at the N-terminus. It has an essential role in the normal development of the urogenital system, and it is mutated in a small subset of patients with Wilms tumor. This gene exhibits complex tissue-specific and polymorphic imprinting pattern, with biallelic, and monoallelic expression from the maternal and paternal alleles in different tissues. Multiple transcript variants have been described. In several variants, there is evidence for the use of a non-AUG (CUG) translation initiation codon upstream of, and in-frame with the first AUG. Authors of PMID:7926762 also provide evidence that WT1 mRNA undergoes RNA editing in human and rat, and that this process is tissue-restricted and developmentally regulated.

Associated Disease
  • Cancer

TCR Vector Products Product list:

Catalog Target Target
Species 		Antibody
Clone 		scFv-Host
Animal 		Vector
length 		Vector
Type 		Epitope Format HLA Data
sheet		 Price
TCR-C259Z WT1 Human TAK1 Human ~8kb Lentiviral CMTWNQMNL Codon optimized HLA-A24 Inquiry
TCR-C260Z WT1 Human Human ~8kb Lentiviral RMFPNAPYL Cysteine-modified HLA-A2 Inquiry
TCR-L122Z WT1 Human Human 8kb Lentiviral RMFPNAPYL Non-modified HLA-A2 Inquiry
TCR-L123 WT1 Human Human 3817bp retroviral vector RMFPNAPYL Non-modified TCR HLA-A2 Inquiry
TCR-L123Z WT1 Human Murinized (from Human) 8kb Lentiviral RMFPNAPYL Murinized HLA-A2 Inquiry
TCR-L124 WT1 Human Murinized (from Human) 3817bp retroviral vector RMFPNAPYL Murinized TCR HLA-A2 Inquiry
TCR-L124Z WT1 Human Human 8kb Lentiviral CMTWNQMNL Non-modified HLA-A24 Inquiry
TCR-L125 WT1 Human Human 3817bp retroviral vector CMTWNQMNL Non-modified TCR HLA-A24 Inquiry
TCR-L125Z WT1 Human Human 8kb Lentiviral RMFPNAPYL Codon optimized Inquiry
TCR-L264 WT1 Human P22 Human ~8kb Lentiviral RMFPNAPYL Single-chain HLA-A2 Inquiry
TCR-L265 WT1 Human D13 Human ~8kb Lentiviral RMFPNAPYL Single-chain HLA-A2 Inquiry
TCR-L266 WT1 Human D13.1 Human ~8kb Lentiviral RMFPNAPYL Single-chain HLA-A2 Inquiry
TCR-L267 WT1 Human D13.0.1 Human ~8kb Lentiviral RMFPNAPYL Single-chain HLA-A2 Inquiry
TCR-L268 WT1 Human D13.1 .1 Human ~8kb Lentiviral RMFPNAPYL Single-chain HLA-A2 Inquiry
TCR-L360 WT1 Human 37F8 Human ~8kb Lentiviral CMTWNQMNL Non-modified HLA-A*24:02 Inquiry
TCR-L361 WT1 Human 32F3 Murinized ~8kb Lentiviral CMTWNQMNL Non-modified HLA-A*24:02 Inquiry

TCR Viral Particles Product list:

Catalog Target
Species 		Antibody
Clone 		scFv-Host
Animal 		Packaging
System 		Epitope Format Titer Data
sheet		 Price
VP-TCR-C583 Human TAK1 Human Lentivirus CMTWNQMNL Codon optimized TCR > 10⁷ IFU/ml Inquiry
VP-TCR-C584 Human Human Lentivirus RMFPNAPYL Cysteine-modified TCR > 10⁷ IFU/ml Inquiry
VP-TCR-C585 Human P22 Human Lentivirus RMFPNAPYL Single-Chain TCR > 10⁷ IFU/ml Inquiry
VP-TCR-C586 Human D13 Human Lentivirus RMFPNAPYL Single-Chain TCR > 10⁷ IFU/ml Inquiry
VP-TCR-C587 Human D13.1 Human Lentivirus RMFPNAPYL Single-Chain TCR > 10⁷ IFU/ml Inquiry
VP-TCR-C588 Human D13.0.1 Human Lentivirus RMFPNAPYL Single-Chain TCR > 10⁷ IFU/ml Inquiry
VP-TCR-C589 Human D13.1 .1 Human Lentivirus RMFPNAPYL Single-Chain TCR > 10⁷ IFU/ml Inquiry
VP-TCR-C590 Human 37F8 Human Lentivirus CMTWNQMNL Non-modified TCR > 10⁷ IFU/ml Inquiry
VP-TCR-C591 Human 32F3 Murinized Lentivirus CMTWNQMNL Non-modified TCR > 10⁷ IFU/ml Inquiry
VP-TCR-C592 Human Human Lentivirus RMFPNAPYL Non-modified TCR > 10⁷ IFU/ml Inquiry
VP-TCR-C593 Human Murinized (from Human) Lentivirus RMFPNAPYL Murinized TCR > 10⁷ IFU/ml Inquiry
VP-TCR-C594 Human Human Lentivirus RMFPNAPYL Codon optimized TCR > 10⁷ IFU/ml Inquiry
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