1. Home
  2. WT1
  3. Human anti-WT1 (aa126-134) T cell receptor (Codon optimized), pCDTCR1

anti-WT1 (aa126-134) TCR, pCDTCR1(TCR-L125Z)

DatasheetDatasheet

Online Inquiry

The vector of anti-WT1 T cell receptor (TCR) is constructed for the engineering of T cell to target Human WT1. The T cells are genetically modified through transduction with a retroviral vector expressing WT1-specific T cell receptor. And the vector product was designed for the treatment of AML, CML, MDS and in breast, colon and ovarian cancer.

Details

Target
WT1
Target Species
Human
Epitope
RMFPNAPYL
Format
Codon optimized
Targeting Diseases
AML, CML, MDS and in breast, colon and ovarian cancer
Vector Name
pCDTCR1
Vector Length
8kb
Vector Type
Lentiviral
Antibody Host
Human

Target

Gene Name
Human Wilms Tumor 1
Official Symbol
WT1
Gene ID
7490
UniProt ID
P19544
Synonyms
WT1; WIT-2; EWS-WT1; Amino-Terminal Domain Of EWS; Last Three Zinc Fingers Of The DNA-Binding Domain Of WT1; WT33; Wilms Tumor Protein; AWT1
Introduction
This gene encodes a transcription factor that contains four zinc-finger motifs at the C-terminus and a
proline/glutamine-rich DNA-binding domain at the N-terminus. It has an essential role in the normal
development of the urogenital system, and it is mutated in a small subset of patients with Wilms
tumor. This gene exhibits complex tissue-specific and polymorphic imprinting pattern, with biallelic,
and monoallelic expression from the maternal and paternal alleles in different tissues. Multiple
transcript variants have been described. In several variants, there is evidence for the use of a nonAUG
(CUG) translation initiation codon upstream of, and in-frame with the first AUG. Authors of
PMID:7926762 also provide evidence that WT1 mRNA undergoes RNA editing in human and rat, and
that this process is tissue-restricted and developmentally regulated.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

Related Products

Cat# Description
VP-TCR-C591 Lenti-WT1 T cell receptor (32F3) Viral Particle
VP-TCR-C588 Lenti-WT1 T cell receptor (D13.0.1) Viral Particle
TCR-C259Z Human anti-WT1 T cell receptor (TAK1), pCDTCR1
TCR-L122Z Human anti-WT1 (aa126-134) T cell receptor, pCDTCR1
TCR-L124Z Human anti-WT1 (aa235-243) T cell receptor, pCDTCR1
TCR-L123Z Murinized anti-WT1 (aa126-134) T cell receptor, pCDTCR1
VP-TCR-C586 Lenti-WT1 T cell receptor (D13) Viral Particle
TCR-L124 Murinized (from Human) anti-WT1 (RMFPNAPYL) T Cell Receptor, pMP71
TCR-L267 Human anti-WT1 T cell receptor (D13.0.1), pCDTCR1
TCR-L268 Human anti-WT1 T cell receptor (D13.1 .1), pCDTCR1

LeukemiaOthers Kits for CARs/TCRs Development 

Online Inquiry

Name:
* Phone:
*E-mail Address:
*Service & Products Interested:
Project Description:
*Verification Code:
Please input "biolabs"(case insensitive) as verification code.
CB Promise
CONTACT US
45-1 Ramsey Road, Shirley, NY 11967, USA
USA: 1-631-381-2994
Europe: 44-207-097-1828
Fax: 1-631-207-8356
Email:
CONTACT US

USA
45-1 Ramsey Road, Shirley, NY 11967, USA
Tel: 1-631-381-2994
Fax: 1-631-207-8356
Email:

Europe
Ringstrasse 4, 64401 Gross-Bieberau, Germany
Tel: 44-207-097-1828

Distributors

To view the contact information for a specific location, select your country or region:

Australia
australia

FOLLOW US ON

Copyright © 2007 - 2018 Creative Biolabs. All Rights Reserved