Creative Biolabs proudly presents to our worldwide clients this professional service of ligand-binding assays, as part of our comprehensive portfolio of antibody functional analysis.
Ligand-binding assay (LBA) is characterized as an evaluation method to quantify the binding ability of an analyte to its specific target, representing the initial step of antibody functional assessment. It can provide direct evidence whether the antibody candidate can bind to particular target properly. Especially for therapeutic antibodies, which rely on specific binding activities to deliver certain clinical effects, binding affinities and selectivity play a vital role in determining drug efficacy and safety. Therefore, LBA profiles are commonly required by most regulatory agencies, like FDA and EMA, as an essential part of IND submission package.
As a long-term pioneer in the field of therapeutic antibody discovery and development, Creative Biolabs offers world-class LBA service to help our customers to assess and validate the binding characteristics of investigated antibodies. The assay can be performed in GLP-compliant laboratories under regulatory guidelines, ensuring most compelling and reproducible outcomes to support downstream studies. Equipped with state-of-the-art technique platforms and seasoned scientific staff, Creative Biolabs has developed, optimized and qualified a full range of different LBA formats designed for antibodies, which can meet worldwide regulatory standards. Diverse LBA approaches are available in Creative Biolabs, including but not limited to:
To guarantee best assay performance, we take special measures to facilitate the assay's selectivity, sensitivity, and quantitation range while minimizing matrix interference effects. It is also well-adaptable to automatic high-throughput studies. Notably, we have extensive experience in designing custom LBA to address various specific issues. Our erudite experts will help you to select the most appropriate assay reagent and format, establish tailored experiment protocols and come up with comprehensive and reproducible results. In addition, we also provide immunogenicity test and Fc binding profiling service using our elegant ligand-binding assay platform, for your reference.
With our versatile and robust LBA technical platform and seasoned team of experts, Creative Biolabs is the right choice to deliver holistic and reliable antibody binding profiles based on ligand-binding assays. For more detailed information, please feel free to contact us or directly sent us an inquiry.
For Research Use Only.
