Mucin Detection Service

Creative Biolab is a top expert in the field of tumor-associated Glycan detection services. With years of experience and our advanced platform, our scientists are confident in offering the best service for our customers all over the world.

Introduction of Mucin

Mucins are a family of high molecular weight, multifunctional glycoproteins produced by epithelial tissues. Mucins are classified into two structural classes - membrane-bound and gel-forming mucins. They serve many functions from lubrication to cell signaling and forming barriers to pathogens and noxious substances. The mucins have been linked to a variety of cancers and are the targets of many antibodies of the tumor.

Fig.1 Schematic structure of mucin glycoproteins. (Balabushevich, 2019)

Among the various mucins, mucin 1 protein (MUC1) is the most studied mucin. Abnormal expression of MUC1 is found in most adenocarcinomas. Therefore, MUC1 has been suggested to be a ponderable marker for early tumor diagnosis. In addition, studies have revealed the differential expression levels of several mucins between breast cancer tissues and normal breast tissues and the important roles of mucins in modulating proliferative, invasive, and metastatic of tumor cells. Mucins mainly function through many unique domains that can form a complex association with different signaling molecules including growth factor receptors and intercellular adhesion molecules.

Traditional Techniques

The detection of cancer markers such as mucins is significant for the early diagnosis and timely treatment of cancer. There are many traditional techniques used to detect mucins. These methods mainly include enzyme-linked immunosorbent assay (ELISA), western blotting, immunohistochemistry, dot blotting, and immunofluorescence. Despite being quite widely used, most traditional techniques have some side effects such as relying on expensive equipment, time-consuming and labor-intensive. These shortcomings greatly limit their role in real-time clinical diagnostics. Hence, the development of new methods for the sensitive and specific detection of mucins in various cancers is crucial.

Novel Techniques in Creative Biolabs

Among the new approaches introduced for the detection of mucins, biosensor-based methods gradually became promising. These methods are often inseparable from various biosensors including optical biosensors, aptamer-based biosensors, and electrochemiluminescence biosensors. After years of accumulation, Creative Biolabs has built a perfect technology platform for the detection of bacteria, natural and chemical material, as well as cancer biomarkers. We have accurately mastered various analysis methods for mucins detection based on electrochemistry, fluorescence, colorimetry, and surface-enhanced Raman scattering.

Combined with our advanced techniques and extensive experience, Creative Biolabs provides mucin detection service to satisfy various project demands. Please contact us for more information.

Reference

1. Balabushevich, N. G.; et al. Mucin adsorption on vaterite CaCO3 microcrystals for the prediction of mucoadhesive properties. Journal of colloid and interface science. 2019, 545: 330-339.

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