ConjugateIQ™ UDP-Glucuronosyltransferase 1A4 (UGT1A4) ELISA Kit

CAT#: ITS-0326-YL31
Product Type: Assay Kit
Species: Human
Brand: ConjugateIQ™
Development Stage: ADME
ADME Research Domain: Metabolism
Short Description
Quantifies UGT1A4 protein using a sandwich ELISA method.
Brand
ConjugateIQ™
Development Stage
ADME
ADME Research Domain
Metabolism
Description
This specific sandwich ELISA kit facilitates the precise quantification of UGT1A4 protein concentrations within hepatic and extrahepatic research models. By allowing researchers to monitor expression levels, the assay provides valuable insights into the glucuronidation kinetics of various endogenous and xenobiotic amine substrates. It is a highly effective tool for investigating phase II metabolic pathways, aiding in the thorough assessment of drug clearance and overall metabolic stability.
Features
Optimized ELISA format for selective UGT1A4 protein quantification, supporting efficient characterization of phase II amine-substrate glucuronidation pathways.
Process Relevance
Monitoring UGT1A4 protein concentrations to optimize amine substrate glucuronidation assays and experimental quality control.
Application Stage
Drug discovery, preclinical ADME, and metabolic screening.
Applications
Assess UGT1A4 protein concentrations in hepatocytes to study glucuronidation rates of endogenous and xenobiotic amine substrates.
Qualified With
Internal performance validation using reference standards under defined assay conditions.
Sample Type
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Research Areas
ADME; Drug Metabolism
Size
96 tests
Data Output Type
Absorbance (OD)
LOD
Human: 26 pg/mL
Species
Human
Storage
Upon receipt, please follow the storage recommendations in the USER MANUAL to maintain reagent stability. Follow recommended handling procedures to ensure consistent assay performance.
Storage Comment
Avoid repeated freeze-thaw cycles. Do not store at elevated temperatures for extended periods.
Note
For bulk pricing or custom reagent inquiries, please contact us by email or phone. Products are shipped on ice via FedEx.
Restrictions
For Research Use Only (RUO). Not intended for diagnostic or therapeutic use.
Shipping
Shipped on ice under temperature-controlled conditions.
Background
This isoform is primarily responsible for the glucuronidation of planar phenolic compounds and specific aromatic amines. It facilitates the conversion of lipophilic molecules into more water-soluble derivatives, promoting their systemic excretion.
For Research Use Only | Not For Clinical Use
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