FluxControl™ PXR (NR1I2) ELISA Kit

CAT#: ITS-0326-YL39
Product Type: Assay Kit
Species: Human, Rat, Mouse
Brand: FluxControl™
Development Stage: ADME
ADME Research Domain: Metabolism
Short Description
Quantifies PXR protein using a sandwich ELISA method.
Brand
FluxControl™
Development Stage
ADME
ADME Research Domain
Metabolism
Description
Utilizing a highly specific sandwich ELISA format, this kit allows for the precise quantification of the PXR nuclear receptor. This essential assay supports researchers in predicting the transcriptional induction of various drug-metabolizing enzymes and critical efflux transporters. By delivering accurate protein expression data, it serves as an indispensable tool for investigating xenobiotic-sensing pathways, which are vital for understanding the mechanisms of drug clearance and potential interactions.
Features
Highly specific sandwich ELISA for PXR quantification, essential for predicting transcriptional induction of ADME-relevant drug-metabolizing enzymes and efflux transporters.
Process Relevance
Monitoring PXR receptor levels to ensure robust transcriptional regulation data in drug-metabolizing enzyme induction assays.
Application Stage
Drug discovery, mechanistic studies, and safety assessment.
Applications
Quantify PXR nuclear receptor levels to predict transcriptional induction of drug-metabolizing enzymes and efflux transporter expression.
Qualified With
Internal performance validation using reference standards under defined assay conditions.
Sample Type
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Research Areas
ADME; Drug Metabolism; Pharmacokinetics
Size
96 tests
Data Output Type
Absorbance (OD)
LOD
Rat: 0.096 ng/mL
Human: 0.045 ng/mL
Mouse: 0.091 ng/mL
Species
Human, Rat, Mouse
Storage
Upon receipt, please follow the storage recommendations in the USER MANUAL to maintain reagent stability. Follow recommended handling procedures to ensure consistent assay performance.
Storage Comment
Avoid repeated freeze-thaw cycles. Do not store at elevated temperatures for extended periods.
Note
For bulk pricing or custom reagent inquiries, please contact us by email or phone. Products are shipped on ice via FedEx.
Restrictions
For Research Use Only (RUO). Not intended for diagnostic or therapeutic use.
Shipping
Shipped on ice under temperature-controlled conditions.
Background
This nuclear receptor functions as a master regulator of xenobiotic metabolism by sensing a wide variety of chemical compounds. Its activation triggers the transcriptional induction of cytochrome P450 enzymes and various drug transporters.
For Research Use Only | Not For Clinical Use
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