P450-Metric™ Cytochrome P450 1A1 (CYP1A1) ELISA Kit

CAT#: ITS-0326-YL5
Product Type: Assay Kit
Species: Human, Rat, Simian
Brand: P450-Metric™
Development Stage: ADME
ADME Research Domain: Metabolism
Short Description
Quantifies CYP1A1 using a double-antibody sandwich ELISA.
Brand
P450-Metric™
Development Stage
ADME
ADME Research Domain
Metabolism
Description
This highly specific double-antibody sandwich ELISA kit provides exceptional quantitative detection of Cytochrome P450 1A1 levels in extrahepatic tissue homogenates and cell lysates. Characterized by its remarkable sensitivity, this research-use-only immunoassay assists scientists in mapping aryl hydrocarbon receptor-mediated drug metabolism. It functions as a critical analytical tool for investigating xenobiotic biotransformation, localized pro-drug activation, and fundamental pharmacokinetic behavior in early-stage preclinical drug development workflows.
Features
Delivering exceptional specificity, this quantitative ELISA measures CYP1A1 induction, providing an essential analytical tool for assessing aryl hydrocarbon receptor-mediated drug metabolism and environmental toxicology.
Process Relevance
Measuring CYP1A1 to assess local tissue pharmacokinetics and bioactivation of environmental toxicants.
Application Stage
Preclinical drug discovery, ADME profiling, and pharmacokinetic research
Applications
Assess target protein expression across diverse tissue homogenates and cell culture supernates with this sensitive quantitative ELISA.
Qualified With
Internal performance validation using reference standards under defined assay conditions.
Sample Type
Serum, plasma, tissue homogenates, cell lysates
Research Areas
ADME; Toxicology; Pharmacokinetics; Drug Metabolism
Size
48 / 96 tests
Data Output Type
Absorbance (OD)
LOD
Rat: 0.124 ng/mL
Human: 0.056 ng/mL
Simian: 0.056 ng/mL
Species
Human, Rat, Simian
Storage
Upon receipt, please follow the storage recommendations in the USER MANUAL to maintain reagent stability. Follow recommended handling procedures to ensure consistent assay performance.
Storage Comment
Avoid repeated freeze-thaw cycles. Do not store at elevated temperatures for extended periods.
Note
For bulk pricing or custom reagent inquiries, please contact us by email or phone. Products are shipped on ice via FedEx.
Restrictions
For Research Use Only (RUO). Not intended for diagnostic or therapeutic use.
Shipping
Shipped on ice under temperature-controlled conditions.
Background
Predominantly expressed in extrahepatic tissues, Cytochrome P450 1A1 is a primary downstream target of the aryl hydrocarbon receptor pathway. Its induction serves as a critical biomarker in toxicology and ADME studies for assessing localized pro-drug activation and xenobiotic bio-transformation.
For Research Use Only | Not For Clinical Use
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