anti-MAGEA3 (aa168-176) TCR, pCDTCR1(TCR-L060Z)
The vector of anti-MAGEA3 T cell receptor (TCR) is constructed for the engineering of T cell to target Human MAGEA3. The T cells are genetically modified through transduction with a retroviral vector expressing MAGEA3-specific T cell receptor. And the vector product was designed for the treatment of Melanoma.
Details
Targeting Diseases
Melanoma
Target
Gene Name
MAGE family member A3
Synonyms
CT1.4; MAGE4; MAGE4A; MAGE4B; MAGE-41; MAGE-X2; TCR; T cell receptor; transgenic TCR; antigen-specific T cell receptors; Engineering T-cell receptors; recombinant t cell receptors; specific t cell receptor; modified t cell receptor; retroviral vector; Esophageal cancer; head and neck cancer; non-small cell pulmonary cancer; stomach cancer; Hodgkin's disease
Introduction
This gene is a member of the MAGEA gene family. The members of this family encode proteins with
50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show
considerable variability, suggesting that the existence of this gene family enables the same function
to be expressed under different transcriptional controls. The MAGEA genes are clustered at
chromosomal location Xq28. They have been implicated in some hereditary disorders, such as
dyskeratosis congenita.
Alternative Names MAGEA3; Cancer/Testis
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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Carcinoma
Datasheet
