Close

Anti-MAGE-A3 (KVAELVHFL) T cell receptor (Affinity enhanced), pCDTCR1 (TCR-C122Z)

The vector of anti-MAGE-A3 T cell receptor (TCR) is constructed for the engineering of T cell to target Human MAGE-A3. The T cells are genetically modified through transduction with a lentiviral vector expressing MAGE-A3-specific T cell receptor. And the vector product was designed for the treatment of Melanoma, synovial cell sarcoma, esophageal cancer.

Details

  • Target
  • MAGE-A3
  • Target Species
  • Human
  • Epitope
  • KVAELVHFL
  • Format
  • Affinity enhanced
  • HLA
  • HLA-A*0201
  • Targeting Diseases
  • Melanoma, synovial cell sarcoma, esophageal cancer
  • Vector Name
  • pCDTCR1
  • Vector Length
  • ~8kb
  • Vector Type
  • Lentiviral
  • Antibody Host
  • Mouse

Target

  • Gene Name
  • MAGE family member A3
  • Official Symbol
  • MAGEA3
  • Synonyms
  • CT1.4; MAGE4; MAGE4A; MAGE4B; MAGE-41; MAGE-X2; TCR; T cell receptor; transgenic TCR; antigen-specific T cell receptors; Engineering T-cell receptors; recombinant t cell receptors; specific t cell receptor; modified t cell receptor; retroviral vector; Esophageal cancer; head and neck cancer; non-small cell pulmonary cancer; stomach cancer; Hodgkin's disease
  • Introduction
  • This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

Related Products

Online Inquiry
Products

CONTACT US

45-1 Ramsey Road, Shirley, NY 11967, USA
Call us at:
USA: 1-631-381-2994
Europe: 44-207-097-1828
Fax: 1-631-207-8356
Email:

Online Inquiry

For any technical issues or products/services related questions, please leave your contacts as below, and our team will contact you at earliest convenience to let you know how we can be involved in your projects.

  • Verification code

Key Updates

Receive the latest news and insights to your inbox.