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Anti-MAGE3 (102G10)-FcRɣ CAR-MA (CARMA-W1127)

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All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

The vector of anti-MAGE3 chimeric antigen receptor (CAR) is constructed for the engineering of macrophage cells to target human MAGE3 and induce target cell phagocytosis. The macrophage cells are genetically modified through transduction with a lentiviral vector expressing scFv of anti-MAGE3 antibody (102G10) linked to FcRɣ signaling domains. The vector product was designed for the treatment of NSCLC (MAGE-A3/6), metastatic melanoma (70% MAGE-A1-5).

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Details

  • Target
  • MAGE3
  • Cell Type
  • Macrophage
  • Targeting Diseases
  • NSCLC (MAGE-A3/6), metastatic melanoma (70% MAGE-A1-5)
  • Vector Name
  • pCDCAR1
  • Vector length
  • ~8kb
  • Vector Type
  • Lentiviral vector
  • Size
  • 10 µg
  • Storage
  • Store at -20°C for long term.

CAR Components

  • Promoter
  • EF1a
  • scFv
  • 102G10
  • Hinge
  • CD8
  • TM
  • CD8
  • ICD
  • FcRɣ
  • Marker
  • GFP or N/A
  • Receptor Construction
  • scFv-hinge(CD8)-TM(CD8)-ICD(FcRɣ)
  • Discription of Signaling Cassetes
  • FcRɣ:
    FcRɣ is used as the CAR intracellular signaling domain. As a phagocytosis receptor, FcRɣ has cytosolic Immunoreceptor Tyrosine-based Activation Motifs (ITAMs) that are phosphorylated by Src family kinases. Based on this mechanism, FcRɣ signaling can induce macrophage phagocytosis which has been demonstrated in the published article.
    Fc gamma receptors belong to the group of non-catalytic tyrosine-phosphorylated receptors which share a similar signalling pathway involving phosphorylation of tyrosine residues. The receptors generate signals within their cells through an important activation motif known as an immunoreceptor tyrosine-based activation motif (ITAM). An ITAM is present in the intracellular tail of FcγRIIA, and its phosphorylation induces phagocytosis in macrophages. FcγRI and FcγRIIIA do not have an ITAM but can transmit an activating signal to their phagocytes by interacting with another protein that does. This adaptor protein is called the Fcγ subunit and, like FcγRIIA, contains the two YXXL sequences that are characteristic of an ITAM.

Target

  • Target
  • MAGE3
  • Target Species
  • Human
  • Clone
  • 102G10
  • Host
  • Human
  • Gene Name
  • MAGE family member A3
  • Introduction
  • This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita.
  • Alternative Names
  • HIP8; HYPD; CT1.3; MAGE3; MAGEA6; MAGEA3; MAGE family member A3

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Customer Reviews and Q&As

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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