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EXPLORE MORECreative Biolabs has a tradition of commitment. To achieve efficient execution and regulatory approval, we offer careful considerations of your program for the development of a cellular or gene therapy product – now and in the future.
EXPLORE MOREWe focus on unmet needs and develop novel cellular and gene drugs and solutions that offer significant benefits over existing options.
EXPLORE MORETo accelerate advanced breakthroughs of your projects, we offer broad range of platforms which enable our clients be free to tackle problems with cutting-edge technologies from different angles and in different methods.
EXPLORE MOREUse the resources in our library to help you understand your options and make critical decisions for your study. We offer oncolytic virus, CAR-T, and dendritic cell related documents, as well as newsletter. If you don’t find the answers you’re looking for, contact us for additional assistance.
EXPLORE MORECreative Biolabs is a cellular immunotherapy company dedicated to the development of innovative T cell therapies for the treatment of diseases with a high unmet medical need. Benefiting from our expertise in CAR-T cell development, we are able to harness science and technology to create CAR-Tregs products that support the next generation of cell therapy innovation.
Challenges for Conventional CAR-T Cell
CAR-T cell therapy has shown remarkable efficacy in the treatment of liquid tumors such as acute leukemia and non-Hodgkin's lymphoma, and is therefore considered to be one of the most promising cell-based immunotherapies. However, until recently, the use of CAR T cell therapy was limited to small clinical trials, primarily because these therapies caused a variety of worrying, sometimes fatal side effects in some patients. The most common one is the cytokine release syndrome (CRS). In addition, evidence suggests that CAR-T cells are targeted to activate antigens expressed on T cells, which are transformed into inducible Treg cells as tumor metastasis progresses. Therefore, the innovative CAR cell therapy targeting Treg has attracted the attention of researchers and the public.
Advantages of CAR-Treg Cells
Cellular therapies using polyclonal regulatory T cells (Tregs) in transplantation and autoimmune diseases have been performed in both animal models and clinical trials. However, polyclonal Tregs cause adverse reactions, such as systemic immunosuppression, since a large number of cells are of unknown antigen specificity. This can be avoided by utilizing antigen-specific Tregs, that is, by transfecting the viral vector encoding the chimeric antigen receptor (CAR) of a specific antigen into Treg to achieve precise modification. Recognized advantages include:
Fig.1 Schematic representation the structure of CAR-modified regulatory T cells (CAR-Tregs). (Zhang, 2018)
One-stop CAR-Treg Therapy Development
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