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p53

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons from identical transcript variants (PMIDs: 12032546, 20937277).

Associated Disease
  • Cancer
  • TCR Vector Products
  • TCR Viral Particles
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  • HLA:
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CAT Product Name Target SpeciesTCR CloneTCR Host AnimalEpitopeHLAVector Type Inquiry & Datasheet
TCR-L089 Human anti-TP53 (LLGRNSFEV) T Cell Receptor, pSFG Human Human LLGRNSFEV HLA-A2.1 retroviral vector   Add to Cart   Datasheet
TCR-L090 Human anti-TP53 (LLGRNSFEV) T Cell Receptor, pMSGV1 Human Human LLGRNSFEV HLA-A2 retroviral vector   Add to Cart   Datasheet
TCR-L091 Murinized (from Human) anti-TP53 (LLGRNSFEV) T Cell Receptor, pMSGV1 Human Murinized (from Human) LLGRNSFEV HLA-A2 retroviral vector   Add to Cart   Datasheet
TCR-L092 Murinized (from Human) anti-TP53 (LLGRNSFEV) T Cell Receptor[Cysteine-modified], pMSGV1 Human Murinized (from Human) LLGRNSFEV HLA-A2 retroviral vector   Add to Cart   Datasheet
TCR-L088Z Human anti-p53 (aa264-272) T cell receptor (Single-chain TCR), pCDTCR1 Human Human LLGRNSFEV HLA-A2.1 Lentiviral   Add to Cart   Datasheet
TCR-L089Z Human anti-p53 (aa264-272) T cell receptor, pCDTCR1 Human Human LLGRNSFEV HLA-A2 Lentiviral   Add to Cart   Datasheet
TCR-L090Z Murinized anti-p53 (aa264-272) T cell receptor, pCDTCR1 Human Murinized (from Human) LLGRNSFEV HLA-A2 Lentiviral   Add to Cart   Datasheet
TCR-L091Z Murinized anti-p53 (aa264-272) T cell receptor (Cysteine-modified), pCDTCR1 Human Murinized (from Human) LLGRNSFEV HLA-A2 Lentiviral   Add to Cart   Datasheet
TCR-L322 Human anti-p53 T cell receptor (p-149), pCDTCR1 Human p-149 Human STPPPGTRV HLA-A2.1 Lentiviral   Add to Cart   Datasheet
TCR-L324 Human anti-p53 T cell receptor, pCDTCR1 Human Human LLGRNSFEV HLA-A0201 Lentiviral   Add to Cart   Datasheet

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