p53

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons from identical transcript variants (PMIDs: 12032546, 20937277).

Associated Disease
  • Cancer

TCR Vector Products Product list:

Catalog Target Target
Species
Antibody
Clone
scFv-Host
Animal
Vector
length
Vector
Type
Epitope Format HLA Data
sheet
Price
TCR-L088Z p53 Human Human 8kb Lentiviral LLGRNSFEV Single-chain HLA-A2.1 Inquiry
TCR-L089 p53 Human Human 8200bp retroviral vector LLGRNSFEV Single-chain TCR HLA-A2.1 Inquiry
TCR-L089Z p53 Human Human 8kb Lentiviral LLGRNSFEV Non-modified HLA-A2 Inquiry
TCR-L090 p53 Human Human 6700-8070bp retroviral vector LLGRNSFEV Non-modified TCR HLA-A2 Inquiry
TCR-L090Z p53 Human Murinized (from Human) 8kb Lentiviral LLGRNSFEV Murinized HLA-A2 Inquiry
TCR-L091 p53 Human Murinized (from Human) 6700-8070bp retroviral vector LLGRNSFEV Murinized TCR HLA-A2 Inquiry
TCR-L091Z p53 Human Murinized (from Human) 8kb Lentiviral LLGRNSFEV Murinized and Cysteine-modified HLA-A2 Inquiry
TCR-L092 p53 Human Murinized (from Human) 6700-8070bp retroviral vector LLGRNSFEV Murinized and Cysteine-modified TCR HLA-A2 Inquiry
TCR-L322 p53 Human p-149 Human ~8kb Lentiviral STPPPGTRV Single-chain HLA-A2.1 Inquiry
TCR-L324 p53 Human Human ~8kb Lentiviral LLGRNSFEV Single-chain HLA-A0201 Inquiry

TCR Viral Particles Product list:

Catalog Target
Species
Antibody
Clone
scFv-Host
Animal
Packaging
System
Epitope Format Titer Data
sheet
Price
VP-TCR-C528 Human p-149 Human Lentivirus STPPPGTRV Single-Chain TCR > 10⁷ IFU/ml Inquiry
VP-TCR-C529 Human Human Lentivirus LLGRNSFEV Single-chain TCR > 10⁷ IFU/ml Inquiry
VP-TCR-C530 Human Human Lentivirus LLGRNSFEV Non-modified TCR > 10⁷ IFU/ml Inquiry
VP-TCR-C531 Human Murinized (from Human) Lentivirus LLGRNSFEV Murinized TCR > 10⁷ IFU/ml Inquiry
VP-TCR-C532 Human Murinized (from Human) Lentivirus LLGRNSFEV Murinized and Cysteine-modified TCR > 10⁷ IFU/ml Inquiry
CONTACT US

USA
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Tel: 1-631-871-5806
Fax: 1-631-207-8356
Email:

Europe
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Tel: 44-207-097-1828

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