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anti-p53 (aa264-272) TCR, pCDTCR1 (TCR-L089Z)

The vector of anti-p53 T cell receptor (TCR) is constructed for the engineering of T cell to target Human p53. The T cells are genetically modified through transduction with a retroviral vector expressing p53-specific T cell receptor. And the vector product was designed for the treatment of cancer, allergies, viral infections and autoimmune disorders.

Details

  • Target
  • p53
  • Target Species
  • Human
  • Epitope
  • LLGRNSFEV
  • Format
  • Non-modified
  • HLA
  • HLA-A2
  • Targeting Diseases
  • Cancer, allergies, viral infections and autoimmune disorders.
  • Vector Name
  • pCDTCR1
  • Vector Length
  • 8kb
  • Vector Type
  • Lentiviral
  • Antibody Host
  • Human

Target

  • Gene Name
  • Tumor Protein P53
  • Official Symbol
  • TP53
  • Synonyms
  • TP53; Tumor Protein P53; Phosphoprotein P53; Antigen NY-CO-13; P53; Transformation-Related Protein 53; Cellular Tumor Antigen P53; Mutant Tumor Protein 53; Li-Fraumeni Syndrome
  • Introduction
  • This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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