Creative Biolabs has a tradition of commitment. To achieve efficient execution and regulatory approval, we offer careful considerations of your program for the development of a cellular or gene therapy product – now and in the future.
EXPLORE MORE HighlightsWe focus on unmet needs and develop novel cellular and gene drugs and solutions that offer significant benefits over existing options.
EXPLORE MORE HighlightsThe advent of Chimeric Antigen Receptor T-cell (CAR-T) therapies has revolutionized the field of oncology, providing new avenues for treating various forms of cancer. Our 20 years of experience in the biotechnology sector have equipped us with the expertise and technological capabilities to support the entire lifecycle of CAR-T products, from early development to commercialization.
EXPLORE MORETo accelerate advanced breakthroughs of your projects, we offer broad range of platforms which enable our clients be free to tackle problems with cutting-edge technologies from different angles and in different methods.
EXPLORE MORE HighlightsUse the resources in our library to help you understand your options and make critical decisions for your study. We offer oncolytic virus, CAR-T, and dendritic cell related documents, as well as newsletter. If you don't find the answers you're looking for, contact us for additional assistance.
EXPLORE MORE HighlightsGet a real taste and understanding of the business and culture of one of the world's great research-based cellular and gene therapy discovery and development companies.
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Based on the outstanding expertise and rich experience, Creative Biolabs offer our clients chimeric antigen receptor (CAR) production service with the highest quality. Particularly, viral transfection is our featured service which is reliable and economical.
In the using of our viral transfection service process, viral gene transfer vectors play a significant role. The major advantages of viral vectors are relative ease of manufacture and production. The capacity to stably integrate genetic material into the host genome. More than that, relied on the advanced expertise and technologies, the process of viral transfection was optimized by Creative Biolabs to ensure replication incompetence, low genotoxicity, and low immunogenicity.
Gamma Retroviral Vectors
Gamma-retrovirus (simple retrovirus, retroviral, MLV) transduction is one of the mainstays of current gene therapy approaches, which contains a reverse transcriptase to enable the integration of artificial genes into the host genome in a stable status. To generate a vector, the gamma retroviral coding sequences are replaced by a transgene of interest. With their intrinsic ability to integrate close to cellular gene promoters, gamma retroviral vectors carry can innate ability to perturb the genomic region and result in neoplastic transformation. Therefore, gamma retroviral vectors are used in gene therapy applications.
Lentiviral Vectors
Lentiviral vectors derived from the human immunodeficiency virus (HIV-1) are major tools for gene delivery in mammalian cells. Structurally, lentivirus vectors are similar to their gamma retroviral counterparts. The essential viral genes are replaced with a transgene of interest and the viral genome is stably integrated into the host cell. The advantageous feature of lentivirus vectors is the ability to mediate potent transduction and stable expression into dividing and non-dividing cells both in vitro and in vivo. More than that, lentiviral vectors can improve the specificity, efficacy, and safety.
Clinical-grade Viral Transgene Vector Manufacturing
Creative Biolabs provides streamlined clinical-grade viral vector manufacturing services tailored to specific project needs. Our end-to-end solutions address technical hurdles in compliant vector production, aligning with rigorous regulatory standards.
Creative Biolabs has the capability to enable you to free up your time for core work and project. Our service can be designed to meet your special needs if you have any requirements. If you are interested in our service, please contact us by E-mail and our team will get back to you as soon as possible.
For any technical issues or product/service related questions, please leave your information below. Our team will contact you soon.
All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.
NEWSLETTER
The latest newsletter to introduce the latest breaking information, our site updates, field and other scientific news, important events, and insights from industry leaders
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NEW SOLUTION
CellRapeutics™ In Vivo Cell Engineering: One-stop in vivo T/B/NK cell and macrophage engineering services covering vectors construction to function verification.
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NOVEL TECHNOLOGY
Silence™ CAR-T Cell: A novel platform to enhance CAR-T cell immunotherapy by combining RNAi technology to suppress genes that may impede CAR functionality.
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NEW SOLUTION
Canine CAR-T Therapy Development: From early target discovery, CAR design and construction, cell culture, and transfection, to in vitro and in vivo function validation.
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