ConjuLink™ UGT1A1 Genotyping Kit

CAT#: ITS-0326-WB7
Product Type: Assay Kit
Species: General (All species)
Target: UGT1A1 gene
Brand: ConjuLink™
Development Stage: ADME
ADME Research Domain: Metabolism
Short Description
Detects UGT1A1 genetic polymorphisms associated with drug metabolism and pharmacogenomic variability.
Brand
ConjuLink™
Development Stage
ADME
ADME Research Domain
Metabolism
Description
ConjuLink™ UGT1A1 Genotyping Kit provides a reliable molecular assay for identifying clinically relevant polymorphisms in the UGT1A1 gene. Using optimized PCR-based detection technology, the kit enables accurate characterization of allelic variants affecting glucuronidation capacity. This platform supports pharmacogenomic research, biomarker studies, and investigation of metabolic variability influencing therapeutic response and drug safety.
Features
Highly specific PCR-based detection enables accurate identification of UGT1A1 polymorphic variants influencing glucuronidation capacity and pharmacogenomic response.
Optimized primer and probe design ensures robust amplification and precise discrimination of clinically relevant alleles in genomic DNA samples.
Compatible with standard real-time PCR instruments, enabling streamlined integration into molecular diagnostics and pharmacogenomic research workflows.
Sensitive assay performance supports reliable genotyping using low-input DNA from blood, tissue, or other clinical sample sources.
Process Relevance
Identifies UGT1A1 polymorphisms to predict metabolic variability affecting drug safety and therapeutic response.
Application Stage
Pharmacogenomic research, biomarker discovery, clinical research, and personalized medicine studies.
Applications
Genotyping of UGT1A1 polymorphisms in genomic DNA samples, pharmacogenomic profiling, assessment of drug metabolism variability, biomarker research, ADME profiling studies, and studies investigating toxicity risk of glucuronidated therapeutics.
Qualified With
Internal performance validation using reference standards under defined assay conditions.
Target
UGT1A1 gene
Sample Type
Whole blood, saliva/buccal swabs, and extracted genomic DNA from tissues or other cellular sources.
Assay Measures
Quantitative
Research Areas
Pharmacogenomics, drug metabolism & pharmacokinetics (ADME), personalized medicine, oncology therapeutics, toxicology, molecular diagnostics, etc.
Data Output Type
Qualitative and genotype-specific detection of UGT1A1 allelic variants using PCR-based analysis.
Species
General (All species)
Assay Measures
Quantitative
Storage
Upon receipt, store the kit in accordance with the storage conditions specified in the product manual.
Storage Comment
Avoid repeated freeze-thaw cycles. During use, minimize the time components are exposed to room temperature and return them promptly to -20°C; storage after handling. Do not store at elevated temperatures for extended periods.
Expiry Date
12 months under recommended storage conditions to ensure optimal performance.
Note
For bulk pricing or custom reagent inquiries, please contact us by email or phone. Products are shipped on ice via FedEx.
Restrictions
For Research Use Only (RUO). Not intended for diagnostic or therapeutic use.
Shipping
Shipped on ice under temperature-controlled conditions.
Background
UDP-glucuronosyltransferase 1A1 (UGT1A1) is a key Phase II metabolic enzyme responsible for glucuronidation of bilirubin, hormones, and numerous therapeutic compounds. Genetic polymorphisms in the UGT1A1 gene can significantly alter enzymatic activity, leading to interindividual variability in drug metabolism and toxicity risk.
Pathways
UGT1A1 functions in the Phase II conjugation pathway of xenobiotic metabolism, catalyzing glucuronidation reactions that increase compound solubility and facilitate excretion. This process often follows Phase I oxidation reactions mediated by cytochrome P450 enzymes. Variations in UGT1A1 activity can therefore influence drug clearance, metabolite formation, and susceptibility to drug-induced toxicity.
For Research Use Only | Not For Clinical Use
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