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In Vivo Viral-based CAR-T Cell Engineering Service

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All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

The Prospect of In Vivo Viral-based CAR-T Cell Engineering

Traditional ex vivo CAR-T cells are personalized cell therapy products, which require expensive and time-consuming manufacturing processes and it's easy to cause adverse symptoms such as cytokine release syndrome (CRS). It is extremely important to investigate novel techniques to overcome these obstacles. In vivo viral-based CAR-T cell programming allows direct generation of CAR-T cells in situ. This approach simplifies the operation and avoids the process of engineering T cells in vitro, and reduces possible complications such as CRS.

Fig.1 The main strategies to generate antitumour allogeneic CAR-T cells. (Aparicio, Carlos & Margarita, 2023)Fig.1 Representative examples of the main strategies to produce antitumour allogeneic CAR-T cells.1

Our In Vivo Viral-based CAR-T Cell Engineering Service

Powered by years of experience in CAR-T research, Creative Biolabs has successfully established an in vivo viral-based CAR-T cell engineering service platform to assist our global customers. Our in vivo viral-based CAR-T cell engineering service utilizes integrated viral vectors such as lentiviral (LV) vectors and adenovirus-associated vectors (AAV) to generate CAR-T cells in situ. We support global customers' requirements with all-around comprehensive customized service including but not limited to CAR design, vector construction & modification, in vivo CAR-T programming on animal models, and CAR-T function validation.

Fig.2 Tumor cell xenografted humanized mice for CAR T cell evaluation.Fig.2 Humanized mice xenografted with tumor cells to assess CAR T cells.2

Our Capability

Our Capability

Representative Data

Representative Data1: Several effective in vivo CAR-T cell production with optimization in vector design poses a breakthrough in cancer immunotherapy.

Representative Data2: A lentiviral-based platform for in vivo CAR T-cell engineering, VivoVec, showed anti-tumor efficacy in both hematological and solid cancers.

In the field of in vivo CAR-T engineering, we are committed to developing novel approaches to greatly enhance its effectiveness in cancer therapy. At the same time, we also provide the following related services:


For more details about our in vivo viral-based CAR-T cell engineering service, please don't hesitate to contact us, our seasoned experts will be pleased with your order.

References

  1. Aparicio, Cristina, Carlos Acebal, and Margarita González-Vallinas. "Current approaches to develop "off-the-shelf" chimeric antigen receptor (CAR)-T cells for cancer treatment: a systematic review." Experimental Hematology & Oncology 12.1 (2023): 73.
  2. Mhaidly, Rana, and Els Verhoeyen. "Humanized mice are precious tools for preclinical evaluation of CAR T and CAR NK cell therapies." Cancers 12.7 (2020): 1915.
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