All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.
Traditional ex vivo CAR-T cells are personalized cell therapy products, which require expensive and time-consuming manufacturing processes and it's easy to cause adverse symptoms such as cytokine release syndrome (CRS). It is extremely important to investigate novel techniques to overcome these obstacles. In vivo viral-based CAR-T cell programming allows direct generation of CAR-T cells in situ. This approach simplifies the operation and avoids the process of engineering T cells in vitro, and reduces possible complications such as CRS.
Fig.1 Representative examples of the main strategies to produce antitumour allogeneic CAR-T cells.1
Powered by years of experience in CAR-T research, Creative Biolabs has successfully established an in vivo viral-based CAR-T cell engineering service platform to assist our global customers. Our in vivo viral-based CAR-T cell engineering service utilizes integrated viral vectors such as lentiviral (LV) vectors and adenovirus-associated vectors (AAV) to generate CAR-T cells in situ. We support global customers' requirements with all-around comprehensive customized service including but not limited to CAR design, vector construction & modification, in vivo CAR-T programming on animal models, and CAR-T function validation.
Fig.2 Humanized mice xenografted with tumor cells to assess CAR T cells.2
Representative Data1: Several effective in vivo CAR-T cell production with optimization in vector design poses a breakthrough in cancer immunotherapy.
Representative Data2: A lentiviral-based platform for in vivo CAR T-cell engineering, VivoVec, showed anti-tumor efficacy in both hematological and solid cancers.
In the field of in vivo CAR-T engineering, we are committed to developing novel approaches to greatly enhance its effectiveness in cancer therapy. At the same time, we also provide the following related services:
For more details about our in vivo viral-based CAR-T cell engineering service, please don't hesitate to contact us, our seasoned experts will be pleased with your order.
References
For any technical issues or product/service related questions, please leave your information below. Our team will contact you soon.
The latest newsletter to introduce the latest breaking information, our site updates, field and other scientific news, important events, and insights from industry leaders
LEARN MORE NEWSLETTERCellRapeutics™ In Vivo Cell Engineering: One-stop in vivo T/B/NK cell and macrophage engineering services covering vectors construction to function verification.
LEARN MORE SOLUTIONSilence™ CAR-T Cell: A novel platform to enhance CAR-T cell immunotherapy by combining RNAi technology to suppress genes that may impede CAR functionality.
LEARN MORE NOVEL TECHNOLOGYCanine CAR-T Therapy Development: From early target discovery, CAR design and construction, cell culture, and transfection, to in vitro and in vivo function validation.
LEARN MORE SOLUTION