Creative Biolabs has a tradition of commitment. To achieve efficient execution and regulatory approval, we offer careful considerations of your program for the development of a cellular or gene therapy product – now and in the future.
EXPLORE MORE HighlightsWe focus on unmet needs and develop novel cellular and gene drugs and solutions that offer significant benefits over existing options.
EXPLORE MORE HighlightsThe advent of Chimeric Antigen Receptor T-cell (CAR-T) therapies has revolutionized the field of oncology, providing new avenues for treating various forms of cancer. Our 20 years of experience in the biotechnology sector have equipped us with the expertise and technological capabilities to support the entire lifecycle of CAR-T products, from early development to commercialization.
EXPLORE MORETo accelerate advanced breakthroughs of your projects, we offer broad range of platforms which enable our clients be free to tackle problems with cutting-edge technologies from different angles and in different methods.
EXPLORE MORE HighlightsUse the resources in our library to help you understand your options and make critical decisions for your study. We offer oncolytic virus, CAR-T, and dendritic cell related documents, as well as newsletter. If you don't find the answers you're looking for, contact us for additional assistance.
EXPLORE MORE HighlightsGet a real taste and understanding of the business and culture of one of the world's great research-based cellular and gene therapy discovery and development companies.
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Creative Biolabs offers lentivirus-mediated gene transfer services for the generation of TCR-modified T cells. Lentivirus can effectively integrate its constructed exogenous genes into the genome of various cell types including cytotoxic T lymphocytes (CTLs) and peripheral blood lymphocytes (PBLs), which makes itself an attractive tool for engineering T cells. Several researches have confirmed the safety of lentiviral vectors as they do not increase the mutation or tumor incidence. We provide various lentiviral vectors to meet every customer`s requirement.
T lymphocytes play crucial roles in immunity, there are various gene therapy strategies targeting T cells. And the efficient gene transfer into T cells facilitates the treatment of several genetic dysfunctions, inherited diseases and acquired diseases, etc. In recent years, this strategy has also been proven to be an alternative solution for many diseases such as hemophilia, adenosine deaminase deficiency (ADA) and chronic granulomatous disease (CGD). In order to achieve a long-term gene transfer, various tools and methods are developed and researched. Among which, lentiviral vectors, derived from HIV-1, have shown promise to tansduce various cell types including some resting cell types. Lentiviral vectors allow mitosis-independent nuclear import of the preintegration complex, which make them preferred gene packaging & delivery vectors for transduction of nonproliferating cells. There are mainly three types of strategies that are used to target lentiviral vectors-mediated to a given cell type or tissue. The first strategy is transductional targeting which is achieved by the modification of the vector surface. And the modification of vector surface can be performed by the incorporation of foreign envelope glycoproteins having a natural restricted tropism or the inclusion of specific ligands fused to the envelope proteins that will determine the affinity of the vector for a given target cell. The second strategy is transcriptional targeting that relies on the insertion of a tissue-specific promoter, or a fragment of this promoter, upstream of the therapeutic transgene. The third one is a novel method combining the microRNA (miRNA) post-transcriptional regulation with lentiviral technology.
With rich experience, Creative Biolabs will offer safe and well controlled expression systems used in TCR gene transfer.
The most popular strategies used for TCR gene transfer:
| ➤ | Viral vectors: |
Retroviral vectors Lentiviral vectors |
| ➤ | Electroporation |
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All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.
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