Glypican-3 (GPC3)

Glypican 3 (GPC3), also known as DGSX, GTR2-2, MXR7, OCI-5, SDYS, SGB, SGBS, SGBS1, is encoded by the GPC3 gene that belongs to the member of the glypican family. This protein is highly expressed in embryonal tissues such as the developing intestine and the mesoderm-derived tissue, and its expression is downregulated in most adult tissue. GPC3 is able not only to bind more than one growth factor, but also to functionally affect the signaling of different growth factors. GPC3 is related to hepatocellular carcinoma, Wilm's tumor, colorectal malignancie, neuroblastoma, medullary cell carcinoma, mesothelioma, ovarian cancer and breast cancer.

Associated Disease

CAR Vector Products Product list:

Catalog Targeting
Cell Type
Generation Antibody
Clone
Vector
Length
Vector
Type
Vector Design Antibody
Host
Data
sheet
Price
CAR-LC046 T cell First GC33 ~8kb Retroviral scFv-CD3ζ Mouse Inquiry
CAR-LC047 T cell Second GC33 ~8kb Retroviral scFv-CD28-CD3ζ Mouse Inquiry
CAR-LC048 T cell Second GC33 ~8kb Retroviral scFv-41BB-CD3ζ Mouse Inquiry
CAR-LC049 T cell Third GC33 ~8kb Retroviral scFv-CD28-41BB-CD3ζ Mouse Inquiry
CAR-LC090 T cell First ~8kb Lentiviral scFv-CD3ζ Human Inquiry
CAR-LC091 T cell Second ~8kb Lentiviral scFv-CD28-CD3ζ Human Inquiry
CAR-LC092 T cell Second ~8kb Lentiviral scFv-41BB-CD3ζ Human Inquiry
CAR-LC093 T cell Third ~8kb Lentiviral scFv-CD28-41BB-CD3ζ Human Inquiry
CAR-LC178 T cell First 3E11 ~8kb Lentiviral scFv-CD3ζ Human Inquiry
CAR-LC179 T cell Second 3E11 ~8kb Lentiviral scFv-CD28-CD3ζ Human Inquiry
CAR-LC180 T cell Third 3E11 ~8kb Lentiviral scFv-CD28-41BB-CD3ζ Human Inquiry
CAR-LC363 T cell Third YP7 ~8kb Lentiviral scFv (GPC3)-CD3ζ/scFv (ASGPR1)-CD28-41BB Mouse Inquiry
CAR-T-1-L342-2 T cell First 9C2 8kb Lentiviral scFv-CD28 Mouse Inquiry
CAR-T-1-L342-G T cell First 9C2 8kb Lentiviral scFv-FcεRIγ Mouse Inquiry
CAR-T-1-L342-Z T cell First 9C2 8kb Lentiviral scFv-CD3ζ Mouse Inquiry
CAR-T-2-L342-2G T cell Second 9C2 8kb Lentiviral scFv-CD28-FcεRIγ Mouse Inquiry
CAR-T-2-L342-2Z T cell Second 9C2 8kb Lentiviral scFv-CD28-CD3ζ Mouse Inquiry
CAR-T-2-L342-4G T cell Second 9C2 8kb Lentiviral scFv-CD4-FcεRIγ Mouse Inquiry
CAR-T-2-L342-4Z T cell Second 9C2 8kb Lentiviral scFv-CD4-CD3ζ Mouse Inquiry
CAR-T-2-L342-8Z T cell Second 9C2 8kb Lentiviral scFv-CD8-CD3ζ Mouse Inquiry
CAR-T-2-L342-BZ T cell Second 9C2 8kb Lentiviral scFv-41BB-CD3ζ Mouse Inquiry
CAR-T-2-L342-CZ T cell Second 9C2 8kb Lentiviral scFv-b2c-CD3ζ Mouse Inquiry
CAR-T-3-L342-2BZ T cell Third 9C2 8kb Lentiviral scFv-CD28-41BB-CD3ζ Mouse Inquiry
CAR-T-3-L342-2XZ T cell Third 9C2 8kb Lentiviral scFv-CD28-OX40-CD3ζ Mouse Inquiry

TCR Vector Products Product list:

Catalog Target Target
Species
Antibody
Clone
scFv-Host
Animal
Vector
length
Vector
Type
Epitope Format HLA Data
sheet
Price
TCR-C088Z Glypican-3 (GPC3) Human P1-1 Murinized ~8kb Lentiviral FIDKKVLKV Codon optimized HLA-A2 Inquiry
TCR-C089Z Glypican-3 (GPC3) Human P2-1 Murinized ~8kb Lentiviral TIHDSIQYV Codon optimized HLA-A2 Inquiry

CAR Viral Particles Product list:

Catalog Antibody
Clone
Packaging
System
Generation Gene
Construct
Promotor Packaging
Cell
Titer Data
sheet
Price
VP-CAR-LC257 9C2 Lentivirus First scFv (9C2)-CD28 CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC258 9C2 Lentivirus First scFv (9C2)-FcεRIγ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC259 9C2 Lentivirus First scFv (9C2)-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC260 9C2 Lentivirus Second scFv (9C2)-CD28-FcεRIγ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC261 9C2 Lentivirus Second scFv (9C2)-CD28-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC262 9C2 Lentivirus Second scFv (9C2)-CD4-FcεRIγ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC263 9C2 Lentivirus First scFv (9C2)-CD4-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC264 9C2 Lentivirus First scFv (9C2)-CD8-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC265 9C2 Lentivirus Second scFv (9C2)-41BB-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC266 9C2 Lentivirus First scFv (9C2)-b2c-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC267 9C2 Lentivirus Third scFv (9C2)-CD28-41BB-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC268 9C2 Lentivirus Third scFv (9C2)-CD28-OX40-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC538 GC33 Lentivirus First scFv (GC33)-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC539 GC33 Lentivirus Second scFv (GC33)-CD28-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC540 GC33 Lentivirus Second scFv (GC33)-41BB-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC541 GC33 Lentivirus Third scFv (GC33)-CD28-41BB-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC579 Lentivirus Second scFv-CD28-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC580 Lentivirus Second scFv-41BB-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC581 Lentivirus Second scFv-CD28-41BB-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC661 3E11 Lentivirus First scFv (3E11)-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC662 3E11 Lentivirus Second scFv (3E11)-CD28-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC663 3E11 Lentivirus Third scFv (3E11)-CD28-41BB-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry

TCR Viral Particles Product list:

Catalog Target
Species
Antibody
Clone
scFv-Host
Animal
Packaging
System
Epitope Format Titer Data
sheet
Price
VP-TCR-C172 Human P1-1 Murinized Lentivirus FIDKKVLKV Codon optimized TCR > 10⁷ IFU/ml Inquiry
VP-TCR-C173 Human P2-1 Murinized Lentivirus TIHDSIQYV Codon optimized TCR > 10⁷ IFU/ml Inquiry
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