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Anti-GPC3 T cell receptor (P1-1), pCDTCR1 (TCR-C088Z)

The vector of anti-GPC3 T cell receptor (TCR) is constructed for the engineering of T cell to target Human GPC3. The T cells are genetically modified through transduction with a lentiviral vector expressing GPC3-specific T cell receptor. And the vector product was designed for the treatment of Hepatocellular carcinoma.

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Details

  • Target
  • Glypican-3 (GPC3)
  • Target Species
  • Human
  • Epitope
  • FIDKKVLKV
  • Format
  • Codon optimized
  • Allele
  • HLA-A2
  • Targeting Diseases
  • Hepatocellular carcinoma
  • Vector Name
  • pCDTCR1
  • Vector Length
  • ~8kb
  • Vector Type
  • Lentiviral
  • TCR Clone
  • P1-1
  • Host Species
  • Murinized

Target

  • Official Symbol
  • GPC3
  • Introduction
  • Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation. The protein encoded by this gene can bind to and inhibit the dipeptidyl peptidase activity of CD26, and it can induce apoptosis in certain cell types. Deletion mutations in this gene are associated with Simpson-Golabi-Behmel syndrome, also known as Simpson dysmorphia syndrome. Alternative splicing results in multiple transcript variants.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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