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This gene encodes a melanocyte-specific type I transmembrane glycoprotein. The encoded protein is enriched in melanosomes, which are the melanin-producing organelles in melanocytes, and plays an essential role in the structural organization of premelanosomes. This protein is involved in generating internal matrix fibers that define the transition from Stage I to Stage II melanosomes. This protein undergoes a complex pattern of prosttranslational processing and modification that is essential to the proper functioning of the protein. A secreted form of this protein that is released by proteolytic ectodomain shedding may be used as a melanoma-specific serum marker. Alternate splicing results in multiple transcript variants.

Associated Disease
  • CAR Vector Products
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CAT Product Name Target Species Antibody Clone Antibody Host Receptor Construction Vector Type Targeting Cell Type Inquiry & Datasheet
CAR-T-2-M552-BZ Anti-gp100 VHH h(41BB-CD3ζ) CAR, [T] Human GPA7 Camelid VHH-41BB-CD3ζ Lentiviral T cell   Add to Cart   Datasheet
CAR-T-2-M552-CZ Anti-gp100 VHH h(b2c-CD3ζ) CAR, [T] Human GPA7 Camelid VHH-b2c-CD3ζ Lentiviral T cell   Add to Cart   Datasheet
CAR-T-1-M552-2 Anti-gp100 VHH h(CD28) CAR, [T] Human GPA7 Camelid VHH-CD28 Lentiviral T cell   Add to Cart   Datasheet
CAR-T-3-M552-2BZ Anti-gp100 VHH h(CD28-41BB-CD3ζ) CAR, [T] Human GPA7 Camelid VHH-CD28-41BB-CD3ζ Lentiviral T cell   Add to Cart   Datasheet
CAR-T-2-M552-2Z Anti-gp100 VHH h(CD28-CD3ζ) CAR, [T] Human GPA7 Camelid VHH-CD28-CD3ζ Lentiviral T cell   Add to Cart   Datasheet
CAR-T-2-M552-2G Anti-gp100 VHH h(CD28-FcεRIγ) CAR, [T] Human GPA7 Camelid VHH-CD28-FcεRIγ Lentiviral T cell   Add to Cart   Datasheet
CAR-T-3-M552-2XZ Anti-gp100 VHH h(CD28-OX40-CD3ζ) CAR, [T] Human GPA7 Camelid VHH-CD28-OX40-CD3ζ Lentiviral T cell   Add to Cart   Datasheet
CAR-T-1-M552-Z Anti-gp100 VHH h(CD3ζ) CAR, [T] Human GPA7 Camelid VHH-CD3ζ Lentiviral T cell   Add to Cart   Datasheet
CAR-T-2-M552-4Z Anti-gp100 VHH h(CD4-CD3ζ) CAR, [T] Human GPA7 Camelid VHH-CD4-CD3ζ Lentiviral T cell   Add to Cart   Datasheet
CAR-T-2-M552-4G Anti-gp100 VHH h(CD4-FcεRIγ) CAR, [T] Human GPA7 Camelid VHH-CD4-FcεRIγ Lentiviral T cell   Add to Cart   Datasheet
CAR-T-2-M552-8Z Anti-gp100 VHH h(CD8-CD3ζ) CAR, [T] Human GPA7 Camelid VHH-CD8-CD3ζ Lentiviral T cell   Add to Cart   Datasheet
CAR-T-1-M552-G Anti-gp100 VHH h(FcεRIγ) CAR, [T] Human GPA7 Camelid VHH-FcεRIγ Lentiviral T cell   Add to Cart   Datasheet

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