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anti-gp100 (aa208-217) TCR, pCDTCR1(TCR-L024Z)

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The vector of anti-gp100 T cell receptor (TCR) is constructed for the engineering of T cell to target Human gp100. The T cells are genetically modified through transduction with a retroviral vector expressing gp100-specific T cell receptor. And the vector product was designed for the treatment of Melanoma.

Details

Target
gp100
Target Species
Human
Epitope
IMDQVPFSV
Format
Non-modified
HLA
HLA-A2
Targeting Diseases
Melanoma
Vector Name
pCDTCR1
Vector Length
8kb
Vector Type
Lentiviral
Antibody Host
Human

Target

Gene Name
premelanosome protein
Official Symbol
PMEL17
Gene ID
6490
UniProt ID
P40967
Synonyms
PMEL; premelanosome protein; SIL, SILV, silver (mouse homolog) like , silver homolog (mouse); melanocyte protein PMEL; D12S53E; gp100; Pmel17; SI; TCR; T cell receptor; transgenic TCR; antigen-specific T cell receptors; Engineering T-cell receptors; recombinant t cell receptors; specific t cell receptor; modified t cell receptor; retroviral vector; Melanoma
Introduction
This gene encodes a melanocyte-specific type I transmembrane glycoprotein. The encoded protein is enriched in melanosomes, which are the melanin-producing organelles in melanocytes, and plays an essential role in the structural organization of premelanosomes. This protein is involved in generating internal matrix fibers that define the transition from Stage I to Stage II melanosomes. This protein undergoes a complex pattern of prosttranslational processing and modification that is essential to the proper functioning of the protein. A secreted form of this protein that is released by proteolytic ectodomain shedding may be used as a melanoma-specific serum marker. Alternate splicing results in multiple transcript variants.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

Related Products

Cat# Description
TCR-L030Z Human anti-gp100 (aa280-288) T cell receptor (Cysteine-modified TCR), pCDTCR1
TCR-L026Z Murinized anti-gp100 (aa208-217) T cell receptor (Cysteine-modified), pCDTCR1
TCR-L023Z Mouse anti-gp100 (aa154-162) T cell receptor, pCDTCR1
TCR-L028 Mouse anti-PMEL17 [154-162] T Cell Receptor, pMSGV1
TCR-L025 Murinized (from Human) anti-PMEL17 (IMDQVPFSV) T Cell Receptor, pMSGV1
TCR-L025Z Murinized anti-gp100 (aa208-217) T cell receptor, pCDTCR1
TCR-L029Z Human anti-gp100 (aa280-288) T cell receptor (Affinity enhanced), pCDTCR1
TCR-L031Z Murinized anti-gp100 (aa154-162) T cell receptor, pCDTCR1
TCR-L031 Murinized (from Human) anti-PMEL17 (KTWGQYWQV) T Cell Receptor, pMSGV1
TCR-L024 Human anti-PMEL17 (IMDQVPFSV) T Cell Receptor, pMSGV1

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Tel: 1-631-381-2994
Fax: 1-631-207-8356
Email:

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Tel: 44-207-097-1828

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