Creative Biolabs has a tradition of commitment. To achieve efficient execution and regulatory approval, we offer careful considerations of your program for the development of a cellular or gene therapy product – now and in the future.
EXPLORE MORE HighlightsWe focus on unmet needs and develop novel cellular and gene drugs and solutions that offer significant benefits over existing options.
EXPLORE MORE HighlightsThe advent of Chimeric Antigen Receptor T-cell (CAR-T) therapies has revolutionized the field of oncology, providing new avenues for treating various forms of cancer. Our 20 years of experience in the biotechnology sector have equipped us with the expertise and technological capabilities to support the entire lifecycle of CAR-T products, from early development to commercialization.
EXPLORE MORETo accelerate advanced breakthroughs of your projects, we offer broad range of platforms which enable our clients be free to tackle problems with cutting-edge technologies from different angles and in different methods.
EXPLORE MORE HighlightsUse the resources in our library to help you understand your options and make critical decisions for your study. We offer oncolytic virus, CAR-T, and dendritic cell related documents, as well as newsletter. If you don't find the answers you're looking for, contact us for additional assistance.
EXPLORE MORE HighlightsGet a real taste and understanding of the business and culture of one of the world's great research-based cellular and gene therapy discovery and development companies.
EXPLORE MORE
Due to our years of experience in genetic T cell engineering field, Creative Biolabs now provides T cell receptor (TCR) service for both clinical diagnostics and immunotherapy development against various cancers.
Cancer is a group of diseases characterized by the uncontrolled growth and spread of abnormal cells, which is a major public health problem all over the world and is the second most common cause of death in the United States according to the mortality data collected by National Center for Health Statistics. It is reported that 1,685,210 new cancer cases and 595,690 cancer deaths are projected to occur in the United States in 2016. Recently, reprogramming T-cell populations by T-cell receptor (TCR) gene transfer> is emerging as a new therapeutic tool for adoptive tumor immunotherapy which achieved desired specificity and efficacy target cancers in several clinical trials. TCR gene therapy has a great deal of advantages compared with the conventional cellular transfer therapy and vaccine therapy using peptides of the cancer antigens. It circumvents the demanding process of in vitro generation of large numbers of specific immune cells and it allows the use of a set of particularly effective TCR genes in large patient groups. By employing TCR gene transfer therapy, it is possible to determine the effective doses of infused cells and also to control the patient's immune background in a different way.
Our high-affinity TCR technology based on screening and isolating specific naturally-occurring TCR on T cells from healthy donor people via affinity binding an antigen/major histocompatibility complex(MHC) of interest, or through engineering a specific T cell receptor by using recombinant technology. Subsequently, we can express this T cell receptor in T lymphocytes, which enable these cells to recognize and bind the specific MHC/antigen complex. One of the major advantages of this approach is that these T cells can recognize intracellular antigens expressed inside the target cells. Furthermore, as these TCRs are derived from human, which makes the reinfused T cells a much lower immunogenicity.
Our sophisticated strategies and first-class TCR technology platform can provide customers high-affinity TCR products with competitive price. Creative Biolabs has the capability to identify or construct T-cell receptors binding various tumor-associated antigens (TAAs), such as MART-1, gp100, NY-ESO-1, MAGE antigens and carcinoembryonic antigen (CEA), with optimal affinity to meet your specific development goal of adoptive T-cell therapy of cancers.
To discuss your demands or to request a proposal, please contact us by .
For any technical issues or product/service related questions, please leave your information below. Our team will contact you soon.
All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.
NEWSLETTER
The latest newsletter to introduce the latest breaking information, our site updates, field and other scientific news, important events, and insights from industry leaders
LEARN MORE NEWSLETTER
NEW SOLUTION
CellRapeutics™ In Vivo Cell Engineering: One-stop in vivo T/B/NK cell and macrophage engineering services covering vectors construction to function verification.
LEARN MORE SOLUTION
NOVEL TECHNOLOGY
Silence™ CAR-T Cell: A novel platform to enhance CAR-T cell immunotherapy by combining RNAi technology to suppress genes that may impede CAR functionality.
LEARN MORE NOVEL TECHNOLOGY
NEW SOLUTION
Canine CAR-T Therapy Development: From early target discovery, CAR design and construction, cell culture, and transfection, to in vitro and in vivo function validation.
LEARN MORE SOLUTION
