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CD19

CD19 (Cluster of Differentiation 19), also called B lymphocyte antigen CD19, is a protein that in human is encoded by CD19 gene.The human CD19 antigen is a 95 kd transmembrane glycoprotein. It is found on the surface of B cell, function as B cell co-receptor that assemble with B cell antigen receptor in order to decrease the shreshold for antigen receptor dependent stimulation. CD19 usually expressed on follicular dendritic cells and B cells. As a hallmark of B cell, CD19 have highly conserved expression on most B cell tumors, though its not strong evidence show if CD19 contributes to B cell carcinogenesis directly. It is expressed in most acute lymphoblastic leukemias (ALL), chronic lymphocytic leukemias (CLL) and B cell lymphomas. In fact, the majority of B cell malignancies express CD19 at normal to high levels (80% of ALL, 88% of B cell lymphomas and 100% of B cell leukemias). For these reason, CD19 also a potential target for lymphoma therapy. Sevral monoclonal antibody and other antibody based immune therapy such as CAR-T technique are target at CD19. It is forseeable that CD19 mAb and molecularly engineered chimeric antigen receptor will be widely studied for therapies of lymphoma, leukemia and autoimmune disorders.

Associated Disease
  • CAR Vector Products
  • TCR Vector Products
  • CAR Viral Particles
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CAT Product Name Target SpeciesAntibody CloneAntibody HostReceptor ConstructionVector TypeTargeting Cell Type Inquiry & Datasheet
CAR-MZ247 Anti-CD19×HER2 scFv h(CD28-41BB-CD3ζ) TanCAR, pCDCAR1 Human CD19 scFv-HER2 scFv-CD28-41BB-CD3ζ Retroviral T cell   Inquiry
  Datasheet
CAR-MZ096 Anti-CD19 (FMC-63) h(2B4-CD3ζ) CAR, pCDCAR1 Human FMC-63 Mouse scFv-2B4-CD3ζ Lentiviral NK cell   Inquiry
  Datasheet
CAR-MZ097 Anti-CD19 (FMC-63) h(t2B4) CAR, pCDCAR1 Human FMC-63 Mouse scFv-t2B4 Lentiviral NK cell   Inquiry
  Datasheet
CAR-MZ098 Anti-CD19 (FMC-63) h(t2B4-CD3ζ) CAR, pCDCAR1 Human FMC-63 Mouse scFv-t2B4-CD3ζ Lentiviral NK cell   Inquiry
  Datasheet
CAR-MZ001 Anti-CD19 scFv h(CTLA4-CD3ζ) CAR, pCDCAR1 Human Human  scFv-CTLA4-CD3ζ Lentiviral T cell   Inquiry
  Datasheet
CAR-MZ020 Anti-CD19 (1D3) h(CD28-CD3ζ) CAR, pCDCAR1 Murine 1D3 Mice scFv-CD28-CD3ζ Retroviral T cell   Inquiry
  Datasheet
CAR-MZ125 Anti-CD19 (SJ25C1) h(CD3ζ) CAR, pCDCAR1 Human SJ25C1 Mouse scFv-CD3ζ Retroviral T cell   Inquiry
  Datasheet
CAR-MZ127 Anti-CD19 (SJ25C1) h(DAP10-CD3ζ) CAR, pCDCAR1 Human SJ25C1 Mouse scFv-DAP10-CD3ζ Retroviral T cell   Inquiry
  Datasheet
CAR-MZ048 Anti-CD19 (Denintuzumab) scFv h(CD3ζ) CAR, pCDCAR1 Human Denintuzumab Human scFv-CD3ζ Lentiviral T cell   Inquiry
  Datasheet
CAR-MZ052 Anti-CD19 scFv h(41BB-CD28-CD3ζ) CAR, pCDCAR1 Human Human scFv-CD28-41BB-CD3ζ Lentiviral T cell   Inquiry
  Datasheet
CAR-MZ128 Anti-CD19 (SJ25C1) h(CD3ζ-DAP10) CAR, pCDCAR1 Human SJ25C1 Mouse scFv-CD3ζ-DAP10 Retroviral T cell   Inquiry
  Datasheet
CAR-MZ129 Anti-CD19 (SJ25C1) h(41BB-CD3ζ) CAR, pCDCAR1 Human SJ25C1 Mouse scFv-41BB-CD3ζ Retroviral T cell   Inquiry
  Datasheet
CAR-MZ130 Anti-CD19 (SJ25C1) h(OX-40-CD3ζ) CAR, pCDCAR1 Human SJ25C1 Mouse scFv-OX40-CD3ζ Retroviral T cell   Inquiry
  Datasheet
CAR-MZ131 Anti-CD19 scFv h(CD3ζ-41BB) CAR, pCDCAR1 Human Humanized scFv-CD3ζ-41BB Lentiviral T cell   Inquiry
  Datasheet
CAR-MZ244 Anti-CD19×HER2 scFv h(CD3ζ) TanCAR, pCDCAR1 Human CD19 scFv-HER2 scFv-CD3ζ Retroviral T cell   Inquiry
  Datasheet
CAR-MZ246 Anti-CD19×HER2 scFv h(41BB-CD3ζ) TanCAR, pCDCAR1 Human CD19 scFv-HER2 scFv-41BB-CD3ζ Retroviral T cell   Inquiry
  Datasheet
CAR-LC353 Anti-CD19 (Denintuzumab) h(41BB-CD3ζ, Her2t) Marked CAR, pCDCAR1 Human Denintuzumab Human scFv-41BB-CD3ζ/Her2t Lentiviral T cell   Inquiry
  Datasheet
CAR-LC355 Anti-CD19×CD22 (FMC63×m971) h(41BB-CD3ζ) TanCAR, pCDCAR1 Human FMC63 Mouse FMC63VL-m971VH-m971VL-FMC63VH-41BB-CD3ζ Lentiviral T cell   Inquiry
  Datasheet
CAR-LC356 Anti-CD19×CD22 (FMC63×m971) h(41BB-CD3ζ) TanCAR, pCDCAR1 Human FMC63 Mouse m971VH-m971VL-FMC63VL-FMC63VH-41BB-CD3ζ Lentiviral T cell   Inquiry
  Datasheet
CAR-LC357 Anti-CD19×ERBB2 scFv h(CD28-CD3ζ) TanCAR, pCDCAR1 Human Blinatumomab Mouse scFv (CD19)-scFv (HER2)-CD28-CD3ζ Retroviral T cell   Inquiry
  Datasheet
CAR-LC358 Anti-CD19×MS4A1 scFv h(41BB-CD3ζ) TanCAR, pCDCAR1 Human Blinatumomab Mouse scFv (CD19)-scFv (HER2)-41BB-CD3ζ Lentiviral T cell   Inquiry
  Datasheet
CAR-LC359 Anti-CD19×CD3 (Blinatumomab) h(41BB-CD3ζ) TanCAR, pCDCAR1 Human Blinatumomab Mouse scFv-41BB-CD3ζ Lentiviral T cell   Inquiry
  Datasheet
CAR-LC369 Anti-CD19 (Inebilizumab) h(CD28-CD3ζ, Anti-CD47 ()) Armoured CAR, pCDCAR1 Human Inebilizumab Human scFv-CD28-CD3ζ Retroviral T cell   Inquiry
  Datasheet
CAR-YF001 Anti-CD19 (FMC635-H4) h(4-1BB-CD3ζ) CAR, pCDCAR1 Human FMC635-H4 Mouse scFv-4-1BB-CD3ζ Lentiviral vector T cell   Inquiry
  Datasheet
CAR-YF002 Anti-CD19 (FMC635-H4) h(CD28-CD3ζ) CAR, pCDCAR1 Human FMC635-H4 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Inquiry
  Datasheet
CAR-YF019 Anti-CD19 (CBL-YF002) h(4-1BB-CD3ζ) CAR, pCDCAR1 Human CBL-YF002 Mouse scFv-4-1BB-CD3ζ Lentiviral vector T cell   Inquiry
  Datasheet
CAR-YF090 Anti-CD19 (HI19a) h(4-1BB-CD3ζ) CAR, pCDCAR1 Human HI19a Mouse scFv-4-1BB-CD3ζ Lentiviral vector T cell   Inquiry
  Datasheet
CAR-YF020 Anti-CD19 (CBL-YF002) h(CD28-CD3ζ) CAR, pCDCAR1 Human CBL-YF002 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Inquiry
  Datasheet
CAR-YF091 Anti-CD19 (HI19a) h(CD28-CD3ζ) CAR, pCDCAR1 Human HI19a Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Inquiry
  Datasheet
CAR-YF025 Anti-CD19 (CBL-YF005) h(4-1BB-CD3ζ) CAR, pCDCAR1 Human CBL-YF005 Humanized scFv-4-1BB-CD3ζ Lentiviral vector T cell   Inquiry
  Datasheet
CAR-YF026 Anti-CD19 (CBL-YF005) h(CD28-CD3ζ) CAR, pCDCAR1 Human CBL-YF005 Humanized scFv-CD28-CD3ζ Lentiviral vector T cell   Inquiry
  Datasheet
CAR-ZP021 Anti-CD19 (FMC63) h(CD28-CD3ζ) CAR, pCDCAR1 Human FMC63 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Inquiry
  Datasheet
CAR-ZP024 Anti-CD19 (PGC3D6H10) h(CD28-CD3ζ) CAR, pCDCAR1 Human PGC3D6H10 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Inquiry
  Datasheet
CAR-ZP047 Anti-CD19 (FMC63) h(41BB-CD3ζ) CAR, pCDCAR1 Human FMC63 Mouse scFv-4-1BB-CD3ζ Lentiviral vector T cell   Inquiry
  Datasheet
CAR-ZP050 Anti-CD19 (PGC3D6H10) h(41BB-CD3ζ) CAR, pCDCAR1 Human PGC3D6H10 Mouse scFv-4-1BB-CD3ζ Lentiviral vector T cell   Inquiry
  Datasheet
CAR-ZP3082 Anti-CD19 (FMC63) h(28-∆IL2RB-ζ(YXXQ) ) CAR, pCDCAR1 Human FMC63 Human ∆NGFR-scFv-CD28-∆IL2RB-CD3ζ-YXXQ Lentiviral vector T cell   Inquiry
  Datasheet
CAR-T-2-L332-2G Anti-CD19 scFv h(CD28-FcεRIγ) CART, pCDCAR1 Human FMC63 Mouse scFv-CD28-FcεRIγ Lentiviral T cell   Inquiry
  Datasheet
CAR-T-2-L332-2Z Anti-CD19 scFv h(CD28-CD3ζ) CART, pCDCAR1 Human FMC63 Mouse scFv-CD28-CD3ζ Lentiviral T cell   Inquiry
  Datasheet
CAR-T-2-L332-4G Anti-CD19 scFv h(CD4-FcεRIγ) CART, pCDCAR1 Human FMC63 Mouse scFv-CD4-FcεRIγ Lentiviral T cell   Inquiry
  Datasheet
CAR-T-2-L332-4Z Anti-CD19 scFv h(CD4-CD3ζ) CART, pCDCAR1 Human FMC63 Mouse scFv-CD4-CD3ζ Lentiviral T cell   Inquiry
  Datasheet

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