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CD19

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CD19 (Cluster of Differentiation 19), also called B lymphocyte antigen CD19, is a protein that in human is encoded by CD19 gene.The human CD19 antigen is a 95 kd transmembrane glycoprotein. It is found on the surface of B cell, function as B cell co-receptor that assemble with B cell antigen receptor in order to decrease the shreshold for antigen receptor dependent stimulation. CD19 usually expressed on follicular dendritic cells and B cells. As a hallmark of B cell, CD19 have highly conserved expression on most B cell tumors, though its not strong evidence show if CD19 contributes to B cell carcinogenesis directly. It is expressed in most acute lymphoblastic leukemias (ALL), chronic lymphocytic leukemias (CLL) and B cell lymphomas. In fact, the majority of B cell malignancies express CD19 at normal to high levels (80% of ALL, 88% of B cell lymphomas and 100% of B cell leukemias). For these reason, CD19 also a potential target for lymphoma therapy. Sevral monoclonal antibody and other antibody based immune therapy such as CAR-T technique are target at CD19. It is forseeable that CD19 mAb and molecularly engineered chimeric antigen receptor will be widely studied for therapies of lymphoma, leukemia and autoimmune disorders.

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CAT Product Name Target Species Antibody Clone Antibody Host Receptor Construction Vector Type Targeting Cell Type Inquiry & Datasheet
CAR-YF001 Anti-CD19 (FMC635-H4) h(4-1BB-CD3ζ) CAR, pCDCAR1 Human FMC635-H4 Mouse scFv-4-1BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-YF002 Anti-CD19 (FMC635-H4) h(CD28-CD3ζ) CAR, pCDCAR1 Human FMC635-H4 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-YF019 Anti-CD19 (CBL-YF002) h(4-1BB-CD3ζ) CAR, pCDCAR1 Human CBL-YF002 Mouse scFv-4-1BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-YF020 Anti-CD19 (CBL-YF002) h(CD28-CD3ζ) CAR, pCDCAR1 Human CBL-YF002 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-YF025 Anti-CD19 (CBL-YF005) h(4-1BB-CD3ζ) CAR, pCDCAR1 Human CBL-YF005 Humanized scFv-4-1BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-YF026 Anti-CD19 (CBL-YF005) h(CD28-CD3ζ) CAR, pCDCAR1 Human CBL-YF005 Humanized scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-YF090 Anti-CD19 (HI19a) h(4-1BB-CD3ζ) CAR, pCDCAR1 Human HI19a Mouse scFv-4-1BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-YF091 Anti-CD19 (HI19a) h(CD28-CD3ζ) CAR, pCDCAR1 Human HI19a Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP021 Anti-CD19 (FMC63) h(CD28-CD3ζ) CAR, pCDCAR1 Human FMC63 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP024 Anti-CD19 (PGC3D6H10) h(CD28-CD3ζ) CAR, pCDCAR1 Human PGC3D6H10 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP047 Anti-CD19 (FMC63) h(41BB-CD3ζ) CAR, pCDCAR1 Human FMC63 Mouse scFv-4-1BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP050 Anti-CD19 (PGC3D6H10) h(41BB-CD3ζ) CAR, pCDCAR1 Human PGC3D6H10 Mouse scFv-4-1BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP3082 Anti-CD19 (FMC63) h(28-∆IL2RB-ζ(YXXQ) ) CAR, pCDCAR1 Human FMC63 Human ∆NGFR-scFv-CD28-∆IL2RB-CD3ζ-YXXQ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-YF418 Anti-CD19 (SJ25C1) h(CD28-41BB-CD3ζ) CAR, pCDCAR1 Human SJ25C1 Mouse scFv-CD28-41BB-CD3ζ Lentiviral vector T Cell   Add to Cart   Datasheet
CAR-YF420 Anti-CD19 (1D3) h(-CD3ζ) CAR, pCDCAR1 Human 1D3 Mouse scFv-CD3ζ Lentiviral vector T Cell   Add to Cart   Datasheet
CAR-YF421 Anti-CD19 (1D3) h(41BB-CD3ζ) CAR, pCDCAR1 Human 1D3 Mouse scFv-41BB-CD3ζ Lentiviral vector T Cell   Add to Cart   Datasheet
CAR-YF422 Anti-CD19 (1D3) h(CD28-41BB-CD3ζ) CAR, pCDCAR1 Human 1D3 Mouse scFv-CD28-41BB-CD3ζ Lentiviral vector T Cell   Add to Cart   Datasheet
CAR-ZP8812 Anti-CD19 (BA0185) h(CD28-CD3ζ) CAR, pcDCAR1 EBV BA0185 Rabbit scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP8813 Anti-CD19 (BA0185) h(4-1BB-CD3ζ) CAR, pcDCAR1 EBV BA0185 Rabbit scFv-4-1BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP8464 A uniCAR [Anti-GCN4 CAR], with a Fab-based CAR Adaptor [Anti-CD19 (FMC63)], a Switchable CAR System Chronic lymphocytic leukemia (CLL) Lentiviral vector   Add to Cart   Datasheet
CAR-ZP8466 A uniCAR [Anti-FITC CAR], with a Fab-based CAR Adaptor [Anti-CD19 (FMC63)], a Switchable CAR System Chronic lymphocytic leukemia (CLL) Lentiviral vector   Add to Cart   Datasheet
CAR-ZP8469 A uniCAR [Anti-GCN4 CAR (28ζ)], with a Fab-based CAR Adaptor [Anti-CD19 (1D3)], a Switchable CAR System Chronic lymphocytic leukemia (CLL) Lentiviral vector   Add to Cart   Datasheet
CAR-ZP8484 A uniCAR [Anti-biotin CAR], with a mAb-based CAR Adaptor [Anti-CD19 (Rituximab)], a Switchable CAR System Chronic lymphocytic leukemia (CLL) Lentiviral vector   Add to Cart   Datasheet
CAR-AB-ZP1 Anti-FMC63 scFv Monoclonal Antibody, FITC-Conjugated Human CAR-T Cell   Add to Cart   Datasheet
CAR-AB-ZP2 Anti-FMC63 scFv Monoclonal Antibody, Biotin-Conjugated Human CAR-T Cell   Add to Cart   Datasheet
CAR-AB-ZP3 Anti-FMC63 scFv Monoclonal Antibody, Unconjugated Human CAR-T Cell   Add to Cart   Datasheet
CAR-ZP8470 A uniCAR [Anti-GCN4 CAR (BBζ)], with a Fab-based CAR Adaptor [Anti-CD19 (1D3)], a Switchable CAR System Chronic lymphocytic leukemia (CLL) Lentiviral vector   Add to Cart   Datasheet
CAR-ZP8471 A uniCAR [Anti-GCN4 CAR(IgG4mTM/mCD28/CD3ζ)], with a Fab-based CAR Adaptor [Anti-CD19 (1D3)], a Switchable CAR System Chronic lymphocytic leukemia (CLL) Lentiviral vector   Add to Cart   Datasheet
CAR-ZP8472 A uniCAR [Anti-GCN4 CAR (IgG4mTM/mCD28/m4-1BB/ CD3ζ)], with a Fab-based CAR Adaptor [Anti-CD19 (1D3)], a Switchable CAR System Chronic lymphocytic leukemia (CLL) Lentiviral vector   Add to Cart   Datasheet
CAR-ZP8473 A uniCAR [Anti-GCN4 CAR (mCD8TM/m4-1BB/CD3ζ)], with a Fab-based CAR Adaptor [Anti-CD19 (1D3)], a Switchable CAR System Chronic lymphocytic leukemia (CLL) Lentiviral vector   Add to Cart   Datasheet
CAR-ZP8474 A uniCAR [Anti-GCN4 CAR (mCD8TM/mCD28/CD3ζ)], with a Fab-based CAR Adaptor [Anti-CD19 (1D3)], a Switchable CAR System Chronic lymphocytic leukemia (CLL) Lentiviral vector   Add to Cart   Datasheet
CAR-ZP8475 A uniCAR [Anti-GCN4 CAR (mCD28/m4-1BB/ CD3ζ)], with a Fab-based CAR Adaptor [Anti-CD19 (1D3)], a Switchable CAR System Chronic lymphocytic leukemia (CLL) Lentiviral vector   Add to Cart   Datasheet
CARP-LX-013 Anti-CD19 h(28ζ) CART, Combined with Ibrutinib, a CAR Plus System Human CD28-CD3ζ Lentiviral vector   Add to Cart   Datasheet
CARP-LX-014 Anti-CD19 h(28ζ) CART, Combined with Acalabrutinib, a CAR Plus System Human CD28-CD3ζ Lentiviral vector   Add to Cart   Datasheet
CARP-LX-015 Anti-CD19 h(28ζ) CART, Combined with To-207, a CAR Plus System Human FMC63 CD28-CD3ζ Lentiviral vector   Add to Cart   Datasheet
CARP-LX-016 Anti-CD19 h(28ζ) CART, Combined with Akt inhibitor viii, a CAR Plus System Human CD28-CD3ζ Lentiviral vector   Add to Cart   Datasheet
CARP-LX-017 Anti-CD19 h(28ζ) CART, Combined with Birb796, a CAR Plus System Mouse CD28-CD3ζ Lentiviral vector   Add to Cart   Datasheet
CARP-LX-018 Anti-CD19 h(28ζ) CART, Combined with Tws119, a CAR Plus System Mouse CD28-CD3ζ Lentiviral vector   Add to Cart   Datasheet
CARP-LX-019 Anti-CD19 h(28ζ) CART, Combined with Idelalisib, a CAR Plus System Human CD28-CD3ζ Lentiviral vector   Add to Cart   Datasheet
CARP-LX-020 Anti-CD19 h(28ζ) CART, Combined with Viphyb, a CAR Plus System Human CD28-CD3ζ Lentiviral vector   Add to Cart   Datasheet
CARP-LX-021 Anti-CD19 h(28ζ) CART, Combined with Jq1, a CAR Plus System Human CD28-CD3ζ Lentiviral vector   Add to Cart   Datasheet
CARP-LX-022 Anti-CD19 h(28ζ) CART, Combined with Itacitinib, a CAR Plus System Human CD28-CD3ζ Lentiviral vector   Add to Cart   Datasheet
CARP-LX-023 Anti-CD19 h(28ζ) CART, Combined with Dasatinib, a CAR Plus System Human FMC63 CD28-CD3ζ Lentiviral vector   Add to Cart   Datasheet
CARP-LX-024 Anti-CD19 h(28ζ) CART, Combined with Ruxolitinib, a CAR Plus System Human CD28-CD3ζ Lentiviral vector   Add to Cart   Datasheet
CARP-LX-058 Anti-CD19 h(BBζ) CART, Combined with Acalabrutinib, a CAR Plus System Human 41BB-CD3ζ Lentiviral vector   Add to Cart   Datasheet
CARP-LX-059 Anti-CD19 h(BBζ) CART, Combined with To-207, a CAR Plus System Human FMC63 41BB-CD3ζ Lentiviral vector   Add to Cart   Datasheet
CARP-LX-060 Anti-CD19 h(BBζ) CART, Combined with Akt inhibitor viii, a CAR Plus System Human 41BB-CD3ζ Lentiviral vector   Add to Cart   Datasheet
CARP-LX-061 Anti-CD19 h(BBζ) CART, Combined with Birb796, a CAR Plus System Mouse 41BB-CD3ζ Lentiviral vector   Add to Cart   Datasheet
CARP-LX-062 Anti-CD19 h(BBζ) CART, Combined with Tws119, a CAR Plus System Mouse 41BB-CD3ζ Lentiviral vector   Add to Cart   Datasheet
CARP-LX-063 Anti-CD19 h(BBζ) CART, Combined with Idelalisib, a CAR Plus System Human 41BB-CD3ζ Lentiviral vector   Add to Cart   Datasheet
CARP-LX-064 Anti-CD19 h(BBζ) CART, Combined with Viphyb, a CAR Plus System Human 41BB-CD3ζ Lentiviral vector   Add to Cart   Datasheet
CARP-LX-065 Anti-CD19 h(BBζ) CART, Combined with Jq1, a CAR Plus System Human 41BB-CD3ζ Lentiviral vector   Add to Cart   Datasheet
CARP-LX-066 Anti-CD19 h(BBζ) CART, Combined with Itacitinib, a CAR Plus System Human 41BB-CD3ζ Lentiviral vector   Add to Cart   Datasheet

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