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CD19

CD19 (Cluster of Differentiation 19), also called B lymphocyte antigen CD19, is a protein that in human is encoded by CD19 gene.The human CD19 antigen is a 95 kd transmembrane glycoprotein. It is found on the surface of B cell, function as B cell co-receptor that assemble with B cell antigen receptor in order to decrease the shreshold for antigen receptor dependent stimulation. CD19 usually expressed on follicular dendritic cells and B cells. As a hallmark of B cell, CD19 have highly conserved expression on most B cell tumors, though its not strong evidence show if CD19 contributes to B cell carcinogenesis directly. It is expressed in most acute lymphoblastic leukemias (ALL), chronic lymphocytic leukemias (CLL) and B cell lymphomas. In fact, the majority of B cell malignancies express CD19 at normal to high levels (80% of ALL, 88% of B cell lymphomas and 100% of B cell leukemias). For these reason, CD19 also a potential target for lymphoma therapy. Sevral monoclonal antibody and other antibody based immune therapy such as CAR-T technique are target at CD19. It is forseeable that CD19 mAb and molecularly engineered chimeric antigen receptor will be widely studied for therapies of lymphoma, leukemia and autoimmune disorders.

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CAT Product Name Target SpeciesAntibody CloneAntibody HostReceptor ConstructionVector TypeTargeting Cell Type Inquiry & Datasheet
CAR-T-2-L332-2G Anti-CD19 scFv h(CD28-FcεRIγ) CART, pCDCAR1 Human FMC63 Mouse scFv-CD28-FcεRIγ Lentiviral T cell   Add to Cart   Datasheet
CAR-T-2-L332-2Z Anti-CD19 scFv h(CD28-CD3ζ) CART, pCDCAR1 Human FMC63 Mouse scFv-CD28-CD3ζ Lentiviral T cell   Add to Cart   Datasheet
CAR-T-2-L332-4G Anti-CD19 scFv h(CD4-FcεRIγ) CART, pCDCAR1 Human FMC63 Mouse scFv-CD4-FcεRIγ Lentiviral T cell   Add to Cart   Datasheet
CAR-T-2-L332-4Z Anti-CD19 scFv h(CD4-CD3ζ) CART, pCDCAR1 Human FMC63 Mouse scFv-CD4-CD3ζ Lentiviral T cell   Add to Cart   Datasheet
CAR-T-2-L332-8Z Anti-CD19 scFv h(CD8-CD3ζ) CART, pCDCAR1 Human FMC63 Mouse scFv-CD8-CD3ζ Lentiviral T cell   Add to Cart   Datasheet
CAR-T-2-L332-BZ Anti-CD19 scFv h(41BB-CD3ζ) CART, pCDCAR1 Human FMC63 Mouse scFv-41BB-CD3ζ Lentiviral T cell   Add to Cart   Datasheet
CAR-T-2-L332-CZ Anti-CD19 scFv h(b2c-CD3ζ) CART, pCDCAR1 Human FMC63 Mouse scFv-b2c-CD3ζ Lentiviral T cell   Add to Cart   Datasheet
CAR-T-3-L332-2BZ Anti-CD19 scFv h(CD28-41BB-CD3ζ) CART, pCDCAR1 Human FMC63 Mouse scFv-CD28-41BB-CD3ζ Lentiviral T cell   Add to Cart   Datasheet
CAR-T-3-L332-2XZ Anti-CD19 scFv h(CD28-OX40-CD3ζ) CART, pCDCAR1 Human FMC63 Mouse scFv-CD28-OX40-CD3ζ Lentiviral T cell   Add to Cart   Datasheet
CAR-NK-1-M328-2 Anti-CD19 scFv h(CD28) CARNK, pCDCAR1 Human FMC63 Mouse scFv-CD28 Lentiviral NK cell   Add to Cart   Datasheet
CAR-NK-1-M328-G Anti-CD19 scFv h(FcεRIγ) CARNK, pCDCAR1 Human FMC63 Mouse scFv-FcεRIγ Lentiviral NK cell   Add to Cart   Datasheet
CAR-NK-1-M328-Z Anti-CD19 scFv h(CD3ζ) CARNK, pCDCAR1 Human FMC63 Mouse scFv-CD3ζ Lentiviral NK cell   Add to Cart   Datasheet
CAR-NK-2-M328-2Z Anti-CD19 scFv h(CD28-CD3ζ) CARNK, pCDCAR1 Human FMC63 Mouse scFv-CD28-CD3ζ Lentiviral NK cell   Add to Cart   Datasheet
CAR-NK-2-M328-4G Anti-CD19 scFv h(CD4-FcεRIγ) CARNK, pCDCAR1 Human FMC63 Mouse scFv-CD4-FcεRIγ Lentiviral NK cell   Add to Cart   Datasheet
CAR-NK-2-M328-4Z Anti-CD19 scFv h(CD4-CD3ζ) CARNK, pCDCAR1 Human FMC63 Mouse scFv-CD4-CD3ζ Lentiviral NK cell   Add to Cart   Datasheet
CAR-NK-2-M328-8Z Anti-CD19 scFv h(CD8-CD3ζ) CARNK, pCDCAR1 Human FMC63 Mouse scFv-CD8-CD3ζ Lentiviral NK cell   Add to Cart   Datasheet
CAR-NK-2-M328-BG Anti-CD19 scFv h(CD28-FcεRIγ) CARNK, pCDCAR1 Human FMC63 Mouse scFv-CD28-FcεRIγ Lentiviral NK cell   Add to Cart   Datasheet
CAR-NK-2-M328-BZ Anti-CD19 scFv h(41BB-CD3ζ) CARNK, pCDCAR1 Human FMC63 Mouse scFv-41BB-CD3ζ Lentiviral NK cell   Add to Cart   Datasheet
CAR-NK-2-M328-CZ Anti-CD19 scFv h(b2c-CD3ζ) CARNK, pCDCAR1 Human FMC63 Mouse scFv-b2c-CD3ζ Lentiviral NK cell   Add to Cart   Datasheet
CAR-NK-3-M328-2BZ Anti-CD19 scFv h(CD28-41BB-CD3ζ) CARNK, pCDCAR1 Human FMC63 Mouse scFv-CD28-41BB-CD3ζ Lentiviral NK cell   Add to Cart   Datasheet
CAR-NK-3-M328-2XZ Anti-CD19 scFv h(CD28-OX40-CD3ζ) CARNK, pCDCAR1 Human FMC63 Mouse scFv-CD28-OX40-CD3ζ Lentiviral NK cell   Add to Cart   Datasheet
CAR-T-1-L332-2 Anti-CD19 scFv h(CD28) CART, pCDCAR1 Human FMC63 Mouse scFv-CD28 Lentiviral T cell   Add to Cart   Datasheet
CAR-T-1-L332-G Anti-CD19 scFv h(FcεRIγ) CART, pCDCAR1 Human FMC63 Mouse scFv-FcεRIγ Lentiviral T cell   Add to Cart   Datasheet
CAR-T-1-L332-Z Anti-CD19 scFv h(CD3ζ) CART, pCDCAR1 Human FMC63 Mouse scFv-CD3ζ Lentiviral T cell   Add to Cart   Datasheet
CAR-LC142 Anti-CD19 (104875) h(41BB-CD3ζ) CAR, pCDCAR1 Human 104875 Human scFv-41BB-CD3ζ Lentiviral T cell   Add to Cart   Datasheet
CAR-LC163 Anti-CD19 (h119a) h(CD28-CD3ζ) CAR, pCDCAR1 Human h119a Human scFv-CD28-CD3ζ Lentiviral T cell   Add to Cart   Datasheet
CAR-LC004 Anti-CD19 (Denintuzumab) h(41BB-CD3ζ) CAR, pCDCAR1 Human Denintuzumab Human scFv-41BB-CD3ζ Lentiviral T cell   Add to Cart   Datasheet
CAR-LC009 Anti-CD19 (47G4) h(CD28-CD3ζ) CAR, pCDCAR1 Human 47G4 Human scFv-CD28-CD3ζ Lentiviral T cell   Add to Cart   Datasheet
CAR-LC010 Anti-CD19 (47G4) h(41BB-CD3ζ) CAR, pCDCAR1 Human 47G4 Human scFv-41BB-CD3ζ Lentiviral T cell   Add to Cart   Datasheet
CAR-LC011 Anti-CD19 (47G4) h(CD27-CD3ζ) CAR, pCDCAR1 Human 47G4 Human scFv-CD27-CD3ζ Lentiviral T cell   Add to Cart   Datasheet
CAR-LC012 Anti-CD19 (47G4) h(CD28-CD27-CD3ζ) CAR, pCDCAR1 Human 47G4 Human scFv-CD28-CD27-CD3ζ Lentiviral T cell   Add to Cart   Datasheet
CAR-LC254 Anti-CD19 h(VNAR-41BB-CD3ζ) CAR, pCDCAR1 Human Cartilaginous fish VNAR-41BB-CD3ζ Lentiviral T cell   Add to Cart   Datasheet
CAR-LC273 Anti-CD19 h(CD3ζ, RXR/EcR) Conditional CAR, pCDCAR1 Human Denintuzumab Human scFv-RXR/EcR-CD3ζ Retroviral T cell   Add to Cart   Datasheet
CAR-LC184 Anti-CD19 (Coltuximab) h(CD3ζ) CAR, pCDCAR1 Human Coltuximab Human scFv-CD3ζ Retroviral T cell   Add to Cart   Datasheet
CAR-LC185 Anti-CD19 (Denintuzumab) h(CD28-CD3ζ) CAR, pCDCAR1 Human Denintuzumab Human scFv-CD28-CD3ζ Retroviral T cell   Add to Cart   Datasheet
CAR-LC013 Anti-CD19 (47G4) h(41BB-CD27-CD3ζ) CAR, pCDCAR1 Human 47G4 Human scFv-41BB-CD27-CD3ζ Lentiviral T cell   Add to Cart   Datasheet
CAR-LC014 Anti-CD19 (47G4) h(CD28-CD27-FcεRIγ) CAR, pCDCAR1 Human 47G4 Human scFv-CD28-CD27-FcεRIγ Lentiviral T cell   Add to Cart   Datasheet
CAR-LC186 Anti-CD19 (Coltuximab) h(41BB-CD3ζ) CAR, pCDCAR1 Human Coltuximab Human scFv-41BB-CD3ζ Retroviral T cell   Add to Cart   Datasheet
CAR-LC193 Anti-CD19 (SJ25C1) h(CD28-CD3ζ) CAR, pCDCAR1 Human SJ25C1 Mouse scFv-CD28-CD3ζ Lentiviral T cell   Add to Cart   Datasheet
CAR-LC274 Anti-CD19 h(CD28-OX40-CD3ζ, FKBP12/FRB) Conditional CAR, pCDCAR1 Human Denintuzumab Human scFv-FKBP12/FRB-CD28-OX40-CD3ζ Retroviral T cell   Add to Cart   Datasheet

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