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Anti-FMC63 scFv Monoclonal Antibody, FITC-Conjugated (CAR-AB-ZP1)


All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

FMC63 is a CD19-specific IgG1 mouse monoclonal antibody, which is a target for immunotherapy of B-lineage leukemia and lymphoma. FMC63 scFv is the most commonly used extracellular domain component of CD19-specific CARs. So far, most of the reported CART-CD19 clinical trials contain anti-CD19 scFv derived from FMC63, such as the two FDA-approved CARs Kymriah and Yescarta. This product was verified to specifically recognize the antigen recognition domain of FMC63-derived CAR.

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Details

  • Target
  • CD19
  • Targeting Cell Type
  • CAR-T Cell
  • Isotype
  • IgG1/kappa
  • Specificity
  • Specifically recognizes the antigen-recognition domain of FMC63 derived CARs.
  • Conjugation
  • FITC
  • Formulation
  • Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.
  • Bioactivity
  • The activity was evaluated by FACS. Anti-CD19 CAR-293 cells were stained with 100 μL of 1:50 dilution FITC-Labeled Monoclonal Anti-FMC63 scFv Antibody and isotype control respectively. FITC signal was used to evaluate the binding activity (QC tested).
  • Reconstitution
  • For best performance, please see the reconstitution protocol provided in the CoA.

Target

  • Host Animal
  • Mouse
  • Expression
  • This product is produced from a hybridoma resulting from fusion of SP2/0 myeloma and B-lymphocytes obtained from a mouse immunized with FMC63 scFv.
  • Target Species
  • Human
  • Gene ID
  • 930

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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