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Anti-CD19 T cell receptor, pCDTCR1 (TCR-ZP010)

The vector of anti-CD19 T cell receptor (TCR) is constructed for the engineering of T cell to target Human CD19. The T cells are genetically modified through transduction with a lentiviral vector expressing CD19-specific T cell receptor. And the vector product was designed for the treatment of Mature B cell neoplasms, acute lymphoblastic leukemia (ALL).

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Details

  • Target
  • CD19
  • Target Species
  • Human
  • Format
  • Chimeric TCR
  • Allele
  • HLA-A2
  • Targeting Diseases
  • Mature B cell neoplasms, acute lymphoblastic leukemia (ALL)
  • Vector Name
  • pCDTCR1
  • Vector Length
  • ~8kb
  • Vector Type
  • Lentiviral vector
  • TCR Clone
  • CBL-Z007
  • Host Species
  • Murinized

Target

  • Official Symbol
  • CD19
  • Introduction
  • CD19 (CD19 Molecule) is a Protein Coding gene. Diseases associated with CD19 include Immunodeficiency, Common Variable, 3 and Common Variable Immunodeficiency. Among its related pathways are RET signaling and Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers. Gene Ontology (GO) annotations related to this gene include signal transducer activity, downstream of receptor.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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