Anti-UL123 T cell receptor (CRV4-4), pCDTCR1 (TCR-YC1255)

The vector of anti-UL123 T cell receptor (TCR) is constructed for the engineering of T cell to target Regulatory protein IE1 (CRVLCCYVL) restricted by HLA-C*07:02. The T cells are genetically modified through transduction with a lentiviral vector expressing UL123-specific T cell receptor.

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  • Target
  • UL123
  • Target Species
  • HCMV
  • Epitope
  • Format
  • Non-Modified TCR
  • Allele
  • HLA-C*07:02
  • Vector Name
  • pCDTCR1
  • Vector Length
  • ~ 8 kb
  • Vector Type
  • Lentiviral vector
  • TCR Clone
  • CRV4-4
  • Host Species
  • Human


  • Introduction
  • Plays an important role in transactivating viral early genes as well as activating its own promoter. Targets and disrupts host PML/nuclear domain 10 (ND10). Promotes efficient viral growth by interacting with and directing host SP100 to degradation, leading to enhanced acetylation level of histones. In addition, functions in counteracting the host innate antiviral response. Inhibits the type I interferon pathway by directly interacting with and sequestrating host STAT2. Alters host cell cycle progression, probably through its interaction with host E2F1 or RB1 that overcomes the RB1-mediated repression of E2F-responsive promoters.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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All services and products are only for lab research use, not for any clinical diagnosis or treatment.

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