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Anti-E7 T cell receptor (A9), pCDTCR1 (TCR-C045Z)

The vector of anti-E7 T cell receptor (TCR) is constructed for the engineering of T cell to target HPV16 E7. The T cells are genetically modified through transduction with a lentiviral vector expressing E7-specific T cell receptor. And the vector product was designed for the treatment of Human papillomavirus infection.

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Details

  • Target
  • E7
  • Target Species
  • HPV16
  • Epitope
  • YMLDLQPETT
  • Format
  • Non-modified
  • Allele
  • HLA-A2
  • Targeting Diseases
  • Cervical cancer
  • Vector Name
  • pCDTCR1
  • Vector Length
  • ~8kb
  • Vector Type
  • Lentiviral
  • TCR Clone
  • A9
  • Host Species
  • Human

Target

  • Official Symbol
  • E7
  • Introduction
  • Human papillomavirus is a DNA virus from the papillomavirus family, of which over 150 types are known. More than 40 types are transmitted through sexual contact and infect the anus and genitals. HPV is typically spread by sustained direct skin-to-skin contact with vaginal and anal sex being the most common methods.E7 plays a role in viral genome replication by driving entry of quiescent cells into the cell cycle. Stimulation of progression from G1 to S phase allows the virus to efficiently use the cellular DNA replicating machinery to achieve viral genome replication. E7 protein has both transforming and trans-activating activities. Induces the disassembly of the E2F1 transcription factor from RB1, with subsequent transcriptional activation of E2F1-regulated S-phase genes. Interferes with host histone deacetylation mediated by HDAC1 and HDAC2, leading to transcription activation. E7 plays also a role in the inhibition of both antiviral and antiproliferative functions of host inteferon alpha.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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