Anti-P24 T cell receptor (C12C), pCDTCR1(TCR-C205Z)
The vector of anti-P24 T cell receptor (TCR) is constructed for the engineering of T cell to target HIV-1 P24. The T cells are genetically modified through transduction with a lentiviral vector expressing P24-specific T cell receptor. And the vector product was designed for the treatment of HIV infection.
P24; gag-pol; Capsid protein p24
Capsid protein p24: Forms the conical core that encapsulates the genomic RNA-nucleocapsid complex in the virion. Most core are conical, with only 7% tubular. The core is constituted by capsid protein hexamer subunits. The core is disassembled soon after virion entry (By similarity). Host restriction factors such as TRIM5-alpha or TRIMCyp bind retroviral capsids and cause premature capsid disassembly, leading to blocks in reverse transcription. Capsid restriction by TRIM5 is one of the factors which restricts HIV-1 to the human species. Host PIN1 apparently facilitates the virion uncoating. On the other hand, interactions with PDZD8 or CYPA stabilize the capsid.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.