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MemDX™ Human CSF1R HEK293T Cell Line (CAT#: S01YF-0123-KX249)

Datasheet
This product is a HEK293T stable cell line. It stably expresses Human CSF1R to provide cell models for research and screening applications.

Product Information

  • Target Protein
  • CSF1R
  • Target Protein Species
  • Human
  • Accession Number
  • NM_005211.2
  • Protein Tag
  • Tag-free
  • Host Cell Type
  • HEK293T
  • Target Classification
  • Kinases/Enzyme
  • Target Family
  • Kinases/Enzyme
  • Target Research Area
  • CNS Research
  • Related Diseases
  • Leukoencephalopathy, Hereditary Diffuse, With Spheroids; Brain Abnormalities, Neurodegeneration, And Dysosteosclerosis

Product Properties

  • Morphology
  • Fibroblastoid cells growing as a monolayer
  • Assay Types
  • Drug screening and biological assays
  • Resistance
  • Puromycin
  • Mycoplasma Testing
  • Negative
  • Sterility Testing
  • 10 passages
  • Biosafety Level
  • Level 1
  • Activity
  • Yes
  • Quantity
  • 5x10⁶ cells
  • Form
  • Frozen cells
  • Freeze Medium
  • 70% DMEM + 20% FBS + 10% DMSO
  • Culture Medium
  • DMEM + 10% FBS + 0.5µg/mL Puromycin
  • Selective Antibiotic(s)
  • Regular antibiotics active against mycoplasmas, bacteria and fungi.
  • Handling Notes
  • Frozen cells should be thawed immediately upon receipt and grown according to handling procedure to ensure cell viability and proper assay performance.
    Note: Do not freeze the cells upon receipt as it may result in irreversible damage to the cell line.
    Disclaimer: We cannot guarantee cell viability if the cells are not thawed immediately upon receipt and grown according to handling procedure.
  • Incubation
  • 37°C with 5% CO₂
  • Applications
  • Drug screening and biological assays
  • Application Notes
  • Cells were plated in a 384-well plate and incubated overnight at 37°C and 5% CO₂ to allow the cells to attach and grow. Cells were then stimulated with a control for high-throughput drugs screening andfunctional assays.
  • Use Restrictions
  • These cells are distributed for research use only.
  • Shipping
  • Dry ice
  • Storage
  • Liquid nitrogen

Target

  • Full Name
  • Colony stimulating factor 1 receptor
  • Introduction
  • The protein encoded by this gene is the receptor for colony stimulating factor 1, a cytokine which controls the production, differentiation, and function of macrophages. This receptor mediates most if not all of the biological effects of this cytokine. Ligand binding activates the receptor kinase through a process of oligomerization and transphosphorylation. The encoded protein is a tyrosine kinase transmembrane receptor and member of the CSF1/PDGF receptor family of tyrosine-protein kinases. Mutations in this gene have been associated with a predisposition to myeloid malignancy. The first intron of this gene contains a transcriptionally inactive ribosomal protein L7 processed pseudogene oriented in the opposite direction. Alternative splicing results in multiple transcript variants. Expression of a splice variant from an LTR promoter has been found in Hodgkin lymphoma (HL), HL cell lines and anaplastic large cell lymphoma.
  • Alternative Names
  • CSF1R; FMS; CSFR; FIM2; HDLS; C-FMS; CD115; CSF-1R; BANDDOS; M-CSF-R; macrophage colony-stimulating factor 1 receptor; CD115 antigen; CSF-1 receptor; FMS proto-oncogene; McDonough feline sarcoma viral (v-fms) oncogene homolog; macrophage colony stimulating factor I receptor; proto-oncogene c-Fms; Colony stimulating factor 1 receptor

Case Studies

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