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MemDX™ Human FLAG tagged TACR1 HEK293T Cell Line, Calcium flux assay (CAT#: S01YF-1022-KX612)

Datasheet
This product is a HEK293T stable cell line. It stably expresses FLAG tagged TACR1 to provide cell models for research and screening applications.

Product Information

  • Target Protein
  • TACR1
  • Target Protein Species
  • Human
  • Accession Number
  • NM_001058.2
  • Protein Tag
  • FLAG-tag at N-terminus
  • Host Cell Type
  • HEK293T
  • Target Classification
  • GPCR
  • Target Family
  • Tachykinin
  • Target Research Area
  • CNS Research; Inflammation Research; Pain and Addiction Research
  • Related Diseases
  • Cystitis; Causalgia

Product Properties

  • Assay Types
  • Calcium flux assay
  • Resistance
  • Puromycin
  • Stability
  • Stable for a minimum of 2 months in continuous culture
  • Mycoplasma Testing
  • Negative
  • Biosafety Level
  • Level 1
  • Activity
  • Yes
  • Quantity
  • 2x10⁶ cells
  • Form
  • Frozen cells
  • Culture Medium
  • DMEM, 10% FBS, 1 μg/mL puromycin
  • Selective Antibiotic(s)
  • Regular antibiotics active against mycoplasmas, bacteria and fungi.
  • Handling Notes
  • Frozen cells should be thawed immediately upon receipt and grown according to handling procedure to ensure cell viability and proper assay performance.
    Note: Do not freeze the cells upon receipt as it may result in irreversible damage to the cell line.
    Disclaimer: We cannot guarantee cell viability if the cells are not thawed immediately upon receipt and grown according to handling procedure.
  • Incubation
  • 37°C with 5% CO₂
  • Applications
  • Drug screening and biological assays
  • Application Notes
  • Cells were plated in a 384-well plate and incubated overnight at 37°C and 5% CO₂ to allow the cells to attach and grow. Cells were then stimulated with a control for high-throughput drugs screening andfunctional assays.
  • Use Restrictions
  • These cells are distributed for research use only.
  • Shipping
  • Dry ice
  • Storage
  • Liquid nitrogen

Target

  • Full Name
  • Tachykinin receptor 1
  • Introduction
  • This gene belongs to a gene family of tachykinin receptors. These tachykinin receptors are characterized by interactions with G proteins and contain seven hydrophobic transmembrane regions. This gene encodes the receptor for the tachykinin substance P, also referred to as neurokinin 1. The encoded protein is also involved in the mediation of phosphatidylinositol metabolism of substance P.
  • GPCR Signaling Pathway
  • The endogenous ligand is tachykinin. Targeted protein activation can cause binding of Gq to G11 protein which, in turn, activate a phosphatidylinositol-calcium second messenger system. It plays a critical role in Major Depressive Disorder and Obsessive-Compulsive Disorder.
  • G coupling
  • Gq
  • Endogenous Ligand
  • Tachykinin
  • Alternative Names
  • SPR; NK1R; NKIR; TAC1R;substance-P receptor;NK-1 receptor;NK-1R;neurokinin receptor 1;tachykinin receptor 1 (substance P receptor; neurokinin-1 receptor);TACR1

Case Studies

Customer reviews and Q&As    

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