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MemDX™ Human FLAG tagged TACR3 HEK293T Cell Line, Calcium flux assay (CAT#: S01YF-1022-KX614)

Datasheet
This product is a HEK293T stable cell line. It stably expresses FLAG tagged TACR3 to provide cell models for research and screening applications.

Product Information

  • Target Protein
  • TACR3
  • Target Protein Species
  • Human
  • Accession Number
  • NM_001059.1
  • Protein Tag
  • FLAG-tag at N-terminus
  • Host Cell Type
  • HEK293T
  • Target Classification
  • GPCR
  • Target Family
  • Tachykinin
  • Target Research Area
  • CNS Research; Reproductive Research
  • Related Diseases
  • Hypogonadotropic Hypogonadism 11 With Or Without Anosmia; Normosmic Congenital Hypogonadotropic Hypogonadism

Product Properties

  • Assay Types
  • Calcium flux assay
  • Resistance
  • Puromycin
  • Stability
  • Stable for a minimum of 2 months in continuous culture
  • Mycoplasma Testing
  • Negative
  • Biosafety Level
  • Level 1
  • Activity
  • Yes
  • Quantity
  • 2x10⁶ cells
  • Form
  • Frozen cells
  • Culture Medium
  • DMEM, 10% FBS, 1 μg/mL puromycin
  • Selective Antibiotic(s)
  • Regular antibiotics active against mycoplasmas, bacteria and fungi.
  • Handling Notes
  • Frozen cells should be thawed immediately upon receipt and grown according to handling procedure to ensure cell viability and proper assay performance.
    Note: Do not freeze the cells upon receipt as it may result in irreversible damage to the cell line.
    Disclaimer: We cannot guarantee cell viability if the cells are not thawed immediately upon receipt and grown according to handling procedure.
  • Incubation
  • 37°C with 5% CO₂
  • Applications
  • Drug screening and biological assays
  • Application Notes
  • Cells were plated in a 384-well plate and incubated overnight at 37°C and 5% CO₂ to allow the cells to attach and grow. Cells were then stimulated with a control for high-throughput drugs screening andfunctional assays.
  • Use Restrictions
  • These cells are distributed for research use only.
  • Shipping
  • Dry ice
  • Storage
  • Liquid nitrogen

Target

  • Full Name
  • Tachykinin receptor 3
  • Introduction
  • This gene belongs to a family of genes that function as receptors for tachykinins. Receptor affinities are specified by variations in the 5'-end of the sequence. The receptors belonging to this family are characterized by interactions with G proteins and 7 hydrophobic transmembrane regions. This gene encodes the receptor for the tachykinin neurokinin 3, also referred to as neurokinin B.
  • GPCR Signaling Pathway
  • The endogenous ligand is tachykinin. Targeted protein activation can cause binding of Gq to G11 protein which, in turn, activate a phosphatidylinositol-calcium second messenger system. It plays a critical role in Major Depressive Disorder and Obsessive-Compulsive Disorder.
  • G coupling
  • Gs & Gq
  • Endogenous Ligand
  • Tachykinin
  • Alternative Names
  • NK3; NKR; HH11; NK3R; NK-3R; TAC3R; TAC3RL;neuromedin-K receptor;NK-3 receptor;NK3 receptor;neurokinin B receptor;neurokinin beta receptor;Tachykinin receptor 3;TACR3

Case Studies

Customer reviews and Q&As    

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